Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats

Detalhes bibliográficos
Autor(a) principal: Rosa, Matheus Camargos de Britto
Data de Publicação: 2022
Outros Autores: Ribeiro, Paula Reis, Silva, Viviam de Oliveira, Selvati‑Rezende, Danubia Aparecida de Carvalho, Silva, Tácio Peres da, Souza, Fernanda Rezende, Cardoso, Maria das Graças, Seixas, Josilene Nascimento, Andrade, Eric Francelino, Pardi, Vanessa, Murata, Ramiro Mendonça, Pereira, Luciano José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/50849
Resumo: Background: Candlenut (CN) has been used indiscriminately for weight loss. In vivo efects of CN in diferent doses are scarce. Objective: To evaluate the efects of CN ingestion in obese rats. Design: Thirty animals (obese and non-obese) received one of three diferent types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose—called 2CN. Treatment was maintained for 28 days. Results: The fatty acid profle of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p<0.05). A dose-dependent carcass fat reduction was observed (p<0.05). Blood levels of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) reduced with CN and increased with 2CN doses (p<0.05). Alanine aminotransferase (ALT) and the atherogenic index remained similar among all treatments (p>0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononu‑ clear leucocyte infltrate. Conclusions: Although CN presented benefcial efects on the metabolism of rats, it also caused increased risk of liver damage.
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spelling Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar ratsPlant extractsObesityToxicityPharmacologyCandlenutPhysiologyNogueira-de-iguapeExtrato de plantasObesidadeFarmacologiaÁcidos graxosBackground: Candlenut (CN) has been used indiscriminately for weight loss. In vivo efects of CN in diferent doses are scarce. Objective: To evaluate the efects of CN ingestion in obese rats. Design: Thirty animals (obese and non-obese) received one of three diferent types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose—called 2CN. Treatment was maintained for 28 days. Results: The fatty acid profle of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p<0.05). A dose-dependent carcass fat reduction was observed (p<0.05). Blood levels of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) reduced with CN and increased with 2CN doses (p<0.05). Alanine aminotransferase (ALT) and the atherogenic index remained similar among all treatments (p>0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononu‑ clear leucocyte infltrate. Conclusions: Although CN presented benefcial efects on the metabolism of rats, it also caused increased risk of liver damage.Springer Nature2022-08-04T22:31:53Z2022-08-04T22:31:53Z2022-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfROSA, M. C. de B. et al. Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats. Diabetology & Metabolic Syndrome, [S.I.], v. 14, 2022. DOI: https://doi.org/10.1186/s13098-022-00847-4.http://repositorio.ufla.br/jspui/handle/1/50849Diabetology & Metabolic Syndromereponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessRosa, Matheus Camargos de BrittoRibeiro, Paula ReisSilva, Viviam de OliveiraSelvati‑Rezende, Danubia Aparecida de CarvalhoSilva, Tácio Peres daSouza, Fernanda RezendeCardoso, Maria das GraçasSeixas, Josilene NascimentoAndrade, Eric FrancelinoPardi, VanessaMurata, Ramiro MendonçaPereira, Luciano Joséeng2023-05-02T10:54:28Zoai:localhost:1/50849Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2023-05-02T10:54:28Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
title Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
spellingShingle Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
Rosa, Matheus Camargos de Britto
Plant extracts
Obesity
Toxicity
Pharmacology
Candlenut
Physiology
Nogueira-de-iguape
Extrato de plantas
Obesidade
Farmacologia
Ácidos graxos
title_short Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
title_full Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
title_fullStr Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
title_full_unstemmed Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
title_sort Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats
author Rosa, Matheus Camargos de Britto
author_facet Rosa, Matheus Camargos de Britto
Ribeiro, Paula Reis
Silva, Viviam de Oliveira
Selvati‑Rezende, Danubia Aparecida de Carvalho
Silva, Tácio Peres da
Souza, Fernanda Rezende
Cardoso, Maria das Graças
Seixas, Josilene Nascimento
Andrade, Eric Francelino
Pardi, Vanessa
Murata, Ramiro Mendonça
Pereira, Luciano José
author_role author
author2 Ribeiro, Paula Reis
Silva, Viviam de Oliveira
Selvati‑Rezende, Danubia Aparecida de Carvalho
Silva, Tácio Peres da
Souza, Fernanda Rezende
Cardoso, Maria das Graças
Seixas, Josilene Nascimento
Andrade, Eric Francelino
Pardi, Vanessa
Murata, Ramiro Mendonça
Pereira, Luciano José
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rosa, Matheus Camargos de Britto
Ribeiro, Paula Reis
Silva, Viviam de Oliveira
Selvati‑Rezende, Danubia Aparecida de Carvalho
Silva, Tácio Peres da
Souza, Fernanda Rezende
Cardoso, Maria das Graças
Seixas, Josilene Nascimento
Andrade, Eric Francelino
Pardi, Vanessa
Murata, Ramiro Mendonça
Pereira, Luciano José
dc.subject.por.fl_str_mv Plant extracts
Obesity
Toxicity
Pharmacology
Candlenut
Physiology
Nogueira-de-iguape
Extrato de plantas
Obesidade
Farmacologia
Ácidos graxos
topic Plant extracts
Obesity
Toxicity
Pharmacology
Candlenut
Physiology
Nogueira-de-iguape
Extrato de plantas
Obesidade
Farmacologia
Ácidos graxos
description Background: Candlenut (CN) has been used indiscriminately for weight loss. In vivo efects of CN in diferent doses are scarce. Objective: To evaluate the efects of CN ingestion in obese rats. Design: Thirty animals (obese and non-obese) received one of three diferent types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose—called 2CN. Treatment was maintained for 28 days. Results: The fatty acid profle of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p<0.05). A dose-dependent carcass fat reduction was observed (p<0.05). Blood levels of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) reduced with CN and increased with 2CN doses (p<0.05). Alanine aminotransferase (ALT) and the atherogenic index remained similar among all treatments (p>0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononu‑ clear leucocyte infltrate. Conclusions: Although CN presented benefcial efects on the metabolism of rats, it also caused increased risk of liver damage.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-04T22:31:53Z
2022-08-04T22:31:53Z
2022-06
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv ROSA, M. C. de B. et al. Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats. Diabetology & Metabolic Syndrome, [S.I.], v. 14, 2022. DOI: https://doi.org/10.1186/s13098-022-00847-4.
http://repositorio.ufla.br/jspui/handle/1/50849
identifier_str_mv ROSA, M. C. de B. et al. Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats. Diabetology & Metabolic Syndrome, [S.I.], v. 14, 2022. DOI: https://doi.org/10.1186/s13098-022-00847-4.
url http://repositorio.ufla.br/jspui/handle/1/50849
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Diabetology & Metabolic Syndrome
reponame:Repositório Institucional da UFLA
instname:Universidade Federal de Lavras (UFLA)
instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
repository.name.fl_str_mv Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)
repository.mail.fl_str_mv nivaldo@ufla.br || repositorio.biblioteca@ufla.br
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