Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFLA |
Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/40972 |
Resumo: | The antihyperglycemic effects of several plant extracts and herbal formulations which are used as antidiabetic formulations have been described and confirmed to date. The main objective of this work was to evaluate the hypoglycemic activity of the aqueous extract of Anacardium humile. Although the treatment of diabetic animals with A. humile did not alter body weight significantly, a reduction of the other evaluated parameters was observed. Animals treated with A. humile did not show variation of insulin levels, possibly triggered by a mechanism of blood glucose reduction. Levels of ALT (alanine aminotransferase) decreased in treated animals, suggesting a protective effect on liver. Levels of cholesterol were also reduced, indicating the efficacy of the extract in reestablishing the balance of nutrients. Moreover, a kidney protection may have been achieved due to the partial reestablishment of blood glucose homeostasis, while no nephrotoxicity could be detected for A. humile. The obtained results demonstrate the effectiveness of A. humile extracts in the treatment of alloxan-induced diabetic rats. Therefore, A. humile aqueous extract, popularly known and used by diabetic patients, induced an improvement in the biochemical parameters evaluated during and following treatment of diabetic rats. Thus, a better characterization of the medicinal potential of this plant will be able to provide a better understanding of its mechanisms of action in these pathological processes. |
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Evaluation of the hypoglycemic properties of Anacardium humile aqueous extractAnacardium humilePlant extractsHerbal formulationsThe antihyperglycemic effects of several plant extracts and herbal formulations which are used as antidiabetic formulations have been described and confirmed to date. The main objective of this work was to evaluate the hypoglycemic activity of the aqueous extract of Anacardium humile. Although the treatment of diabetic animals with A. humile did not alter body weight significantly, a reduction of the other evaluated parameters was observed. Animals treated with A. humile did not show variation of insulin levels, possibly triggered by a mechanism of blood glucose reduction. Levels of ALT (alanine aminotransferase) decreased in treated animals, suggesting a protective effect on liver. Levels of cholesterol were also reduced, indicating the efficacy of the extract in reestablishing the balance of nutrients. Moreover, a kidney protection may have been achieved due to the partial reestablishment of blood glucose homeostasis, while no nephrotoxicity could be detected for A. humile. The obtained results demonstrate the effectiveness of A. humile extracts in the treatment of alloxan-induced diabetic rats. Therefore, A. humile aqueous extract, popularly known and used by diabetic patients, induced an improvement in the biochemical parameters evaluated during and following treatment of diabetic rats. Thus, a better characterization of the medicinal potential of this plant will be able to provide a better understanding of its mechanisms of action in these pathological processes.Hindawi Publishing Corporation2020-05-18T02:58:36Z2020-05-18T02:58:36Z2013-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfURZÊDA, M. A. et al. Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract. Evidence-Based Complementary and Alternative Medicine, [S.l.], v. 2013, p. 1-8, May 2013. DOI: 10.1155/2013/191080.http://repositorio.ufla.br/jspui/handle/1/40972Evidence-Based Complementary and Alternative Medicinereponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessUrzêda, Márcio A.Marcussi, SilvanaPereira, Luciana L. SilvaFrança, Suzelei C.Pereira, Ana Maria S.Pereira, Paulo S.Silva, Saulo L. daGuimarães, César L. S.Calderon, Leonardo A.Stábeli, Rodrigo G.Soares, Andreimar M.Couto, Lucélio B.eng2020-05-18T02:58:36Zoai:localhost:1/40972Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2020-05-18T02:58:36Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
dc.title.none.fl_str_mv |
Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract |
title |
Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract |
spellingShingle |
Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract Urzêda, Márcio A. Anacardium humile Plant extracts Herbal formulations |
title_short |
Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract |
title_full |
Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract |
title_fullStr |
Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract |
title_full_unstemmed |
Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract |
title_sort |
Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract |
author |
Urzêda, Márcio A. |
author_facet |
Urzêda, Márcio A. Marcussi, Silvana Pereira, Luciana L. Silva França, Suzelei C. Pereira, Ana Maria S. Pereira, Paulo S. Silva, Saulo L. da Guimarães, César L. S. Calderon, Leonardo A. Stábeli, Rodrigo G. Soares, Andreimar M. Couto, Lucélio B. |
author_role |
author |
author2 |
Marcussi, Silvana Pereira, Luciana L. Silva França, Suzelei C. Pereira, Ana Maria S. Pereira, Paulo S. Silva, Saulo L. da Guimarães, César L. S. Calderon, Leonardo A. Stábeli, Rodrigo G. Soares, Andreimar M. Couto, Lucélio B. |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Urzêda, Márcio A. Marcussi, Silvana Pereira, Luciana L. Silva França, Suzelei C. Pereira, Ana Maria S. Pereira, Paulo S. Silva, Saulo L. da Guimarães, César L. S. Calderon, Leonardo A. Stábeli, Rodrigo G. Soares, Andreimar M. Couto, Lucélio B. |
dc.subject.por.fl_str_mv |
Anacardium humile Plant extracts Herbal formulations |
topic |
Anacardium humile Plant extracts Herbal formulations |
description |
The antihyperglycemic effects of several plant extracts and herbal formulations which are used as antidiabetic formulations have been described and confirmed to date. The main objective of this work was to evaluate the hypoglycemic activity of the aqueous extract of Anacardium humile. Although the treatment of diabetic animals with A. humile did not alter body weight significantly, a reduction of the other evaluated parameters was observed. Animals treated with A. humile did not show variation of insulin levels, possibly triggered by a mechanism of blood glucose reduction. Levels of ALT (alanine aminotransferase) decreased in treated animals, suggesting a protective effect on liver. Levels of cholesterol were also reduced, indicating the efficacy of the extract in reestablishing the balance of nutrients. Moreover, a kidney protection may have been achieved due to the partial reestablishment of blood glucose homeostasis, while no nephrotoxicity could be detected for A. humile. The obtained results demonstrate the effectiveness of A. humile extracts in the treatment of alloxan-induced diabetic rats. Therefore, A. humile aqueous extract, popularly known and used by diabetic patients, induced an improvement in the biochemical parameters evaluated during and following treatment of diabetic rats. Thus, a better characterization of the medicinal potential of this plant will be able to provide a better understanding of its mechanisms of action in these pathological processes. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-05 2020-05-18T02:58:36Z 2020-05-18T02:58:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
URZÊDA, M. A. et al. Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract. Evidence-Based Complementary and Alternative Medicine, [S.l.], v. 2013, p. 1-8, May 2013. DOI: 10.1155/2013/191080. http://repositorio.ufla.br/jspui/handle/1/40972 |
identifier_str_mv |
URZÊDA, M. A. et al. Evaluation of the hypoglycemic properties of Anacardium humile aqueous extract. Evidence-Based Complementary and Alternative Medicine, [S.l.], v. 2013, p. 1-8, May 2013. DOI: 10.1155/2013/191080. |
url |
http://repositorio.ufla.br/jspui/handle/1/40972 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Evidence-Based Complementary and Alternative Medicine reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
instname_str |
Universidade Federal de Lavras (UFLA) |
instacron_str |
UFLA |
institution |
UFLA |
reponame_str |
Repositório Institucional da UFLA |
collection |
Repositório Institucional da UFLA |
repository.name.fl_str_mv |
Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
_version_ |
1784550184637693952 |