Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms

Detalhes bibliográficos
Autor(a) principal: Oliveira, Natália Leite
Data de Publicação: 2022
Outros Autores: Oliveira, Ana Carolina Salgado de, Silva, Sergio Henrique, Rodrigues, Adrise Aparecida, Borges, Soraia Vilela, Oliveira, Juliano Elvis de, Resende, Jaime Vilela de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFLA
Texto Completo: https://www.mdpi.com/2223-7747/11/23/3298
http://repositorio.ufla.br/jspui/handle/1/59558
Resumo: The use of formulations containing botanical products for controlling insects that vector human and animal diseases has increased in recent years. Plant extracts seem to offer fewer risks to the environment and to human health without reducing the application strategy’s efficacy when compared to synthetic and conventional insecticides and repellents. Here, we evaluated the potential of extracts obtained from caninana, Chiococca alba (L.) Hitchc. (Rubiaceae), plants as a tool to be integrated into the management of Aedes aegypti, one of the principal vectors for the transmission of arborviruses in humans. We assessed the larvicidal and repellence performance against adult mosquitoes and evaluated the potential undesired effects of the extracts on non-target organisms. We assessed the susceptibility and predatory abilities of the nymphs of Belostoma anurum, a naturally occurring mosquito larva predator, and evaluated the C. alba extract’s cytotoxic effects in mammalian cell lines. Our chromatographic analysis revealed 18 compounds, including rutin, naringin, myricetin, morin, and quercetin. The methanolic extracts of C. alba showed larvicidal (LC50 = 82 (72–94) mg/mL) activity without killing or affecting the abilities of B. anurum to prey upon mosquito larvae. Our in silico predictions revealed the molecular interactions between rutin and the AeagOBP1 receptor to be one possible mechanism for the repellent potential recorded for formulations containing C. alba extracts. Low cytotoxicity against mammalian cell lines reinforces the selectivity of C. alba extracts. Collectively, our findings highlight the potential of C. alba and one of its constituents (rutin) as alternative tools to be integrated into the management of A. aegypti mosquitoes.
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spelling Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organismsPesticidas botânicosManejo de Aedes aegyptiAtividade larvicidaExtratos vegetaisInseticidas naturaisBotanical pesticidesAedes aegypti managementLarvicidal activityPlant extractsNatural insecticidesThe use of formulations containing botanical products for controlling insects that vector human and animal diseases has increased in recent years. Plant extracts seem to offer fewer risks to the environment and to human health without reducing the application strategy’s efficacy when compared to synthetic and conventional insecticides and repellents. Here, we evaluated the potential of extracts obtained from caninana, Chiococca alba (L.) Hitchc. (Rubiaceae), plants as a tool to be integrated into the management of Aedes aegypti, one of the principal vectors for the transmission of arborviruses in humans. We assessed the larvicidal and repellence performance against adult mosquitoes and evaluated the potential undesired effects of the extracts on non-target organisms. We assessed the susceptibility and predatory abilities of the nymphs of Belostoma anurum, a naturally occurring mosquito larva predator, and evaluated the C. alba extract’s cytotoxic effects in mammalian cell lines. Our chromatographic analysis revealed 18 compounds, including rutin, naringin, myricetin, morin, and quercetin. The methanolic extracts of C. alba showed larvicidal (LC50 = 82 (72–94) mg/mL) activity without killing or affecting the abilities of B. anurum to prey upon mosquito larvae. Our in silico predictions revealed the molecular interactions between rutin and the AeagOBP1 receptor to be one possible mechanism for the repellent potential recorded for formulations containing C. alba extracts. Low cytotoxicity against mammalian cell lines reinforces the selectivity of C. alba extracts. Collectively, our findings highlight the potential of C. alba and one of its constituents (rutin) as alternative tools to be integrated into the management of A. aegypti mosquitoes.Multidisciplinary Digital Publishing Institute (MDPI)2024-10-09T14:37:52Z2024-10-09T14:37:52Z2022-11-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBORGES, J. C. M.; HADDI, K.; VALBON, W. R.; COSTA, L. T. M.; ASCÊNCIO, S. D.; SANTOS, G. R.; SOARES, I. M.; BARBOSA, R. S.; VIANA, K. F.; SILVA, E. A. P.; MOURA, W. S.; ANDRADE, B. S.; OLIVEIRA, E. E.; AGUIAR, R. W. S. Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms. Plants, Basel, v. 11, p. 3298, 2022. Disponível em: https://doi.org/10.3390/plants11233298. Acesso em: 9 out. 2024.https://www.mdpi.com/2223-7747/11/23/3298http://repositorio.ufla.br/jspui/handle/1/59558Plantsreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessOliveira, Natália LeiteOliveira, Ana Carolina Salgado deSilva, Sergio HenriqueRodrigues, Adrise AparecidaBorges, Soraia VilelaOliveira, Juliano Elvis deResende, Jaime Vilela depor2024-10-09T17:46:54Zoai:localhost:1/59558Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2024-10-09T17:46:54Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms
title Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms
spellingShingle Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms
Oliveira, Natália Leite
Pesticidas botânicos
Manejo de Aedes aegypti
Atividade larvicida
Extratos vegetais
Inseticidas naturais
Botanical pesticides
Aedes aegypti management
Larvicidal activity
Plant extracts
Natural insecticides
title_short Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms
title_full Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms
title_fullStr Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms
title_full_unstemmed Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms
title_sort Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms
author Oliveira, Natália Leite
author_facet Oliveira, Natália Leite
Oliveira, Ana Carolina Salgado de
Silva, Sergio Henrique
Rodrigues, Adrise Aparecida
Borges, Soraia Vilela
Oliveira, Juliano Elvis de
Resende, Jaime Vilela de
author_role author
author2 Oliveira, Ana Carolina Salgado de
Silva, Sergio Henrique
Rodrigues, Adrise Aparecida
Borges, Soraia Vilela
Oliveira, Juliano Elvis de
Resende, Jaime Vilela de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Natália Leite
Oliveira, Ana Carolina Salgado de
Silva, Sergio Henrique
Rodrigues, Adrise Aparecida
Borges, Soraia Vilela
Oliveira, Juliano Elvis de
Resende, Jaime Vilela de
dc.subject.por.fl_str_mv Pesticidas botânicos
Manejo de Aedes aegypti
Atividade larvicida
Extratos vegetais
Inseticidas naturais
Botanical pesticides
Aedes aegypti management
Larvicidal activity
Plant extracts
Natural insecticides
topic Pesticidas botânicos
Manejo de Aedes aegypti
Atividade larvicida
Extratos vegetais
Inseticidas naturais
Botanical pesticides
Aedes aegypti management
Larvicidal activity
Plant extracts
Natural insecticides
description The use of formulations containing botanical products for controlling insects that vector human and animal diseases has increased in recent years. Plant extracts seem to offer fewer risks to the environment and to human health without reducing the application strategy’s efficacy when compared to synthetic and conventional insecticides and repellents. Here, we evaluated the potential of extracts obtained from caninana, Chiococca alba (L.) Hitchc. (Rubiaceae), plants as a tool to be integrated into the management of Aedes aegypti, one of the principal vectors for the transmission of arborviruses in humans. We assessed the larvicidal and repellence performance against adult mosquitoes and evaluated the potential undesired effects of the extracts on non-target organisms. We assessed the susceptibility and predatory abilities of the nymphs of Belostoma anurum, a naturally occurring mosquito larva predator, and evaluated the C. alba extract’s cytotoxic effects in mammalian cell lines. Our chromatographic analysis revealed 18 compounds, including rutin, naringin, myricetin, morin, and quercetin. The methanolic extracts of C. alba showed larvicidal (LC50 = 82 (72–94) mg/mL) activity without killing or affecting the abilities of B. anurum to prey upon mosquito larvae. Our in silico predictions revealed the molecular interactions between rutin and the AeagOBP1 receptor to be one possible mechanism for the repellent potential recorded for formulations containing C. alba extracts. Low cytotoxicity against mammalian cell lines reinforces the selectivity of C. alba extracts. Collectively, our findings highlight the potential of C. alba and one of its constituents (rutin) as alternative tools to be integrated into the management of A. aegypti mosquitoes.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-29
2024-10-09T14:37:52Z
2024-10-09T14:37:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv BORGES, J. C. M.; HADDI, K.; VALBON, W. R.; COSTA, L. T. M.; ASCÊNCIO, S. D.; SANTOS, G. R.; SOARES, I. M.; BARBOSA, R. S.; VIANA, K. F.; SILVA, E. A. P.; MOURA, W. S.; ANDRADE, B. S.; OLIVEIRA, E. E.; AGUIAR, R. W. S. Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms. Plants, Basel, v. 11, p. 3298, 2022. Disponível em: https://doi.org/10.3390/plants11233298. Acesso em: 9 out. 2024.
https://www.mdpi.com/2223-7747/11/23/3298
http://repositorio.ufla.br/jspui/handle/1/59558
identifier_str_mv BORGES, J. C. M.; HADDI, K.; VALBON, W. R.; COSTA, L. T. M.; ASCÊNCIO, S. D.; SANTOS, G. R.; SOARES, I. M.; BARBOSA, R. S.; VIANA, K. F.; SILVA, E. A. P.; MOURA, W. S.; ANDRADE, B. S.; OLIVEIRA, E. E.; AGUIAR, R. W. S. Methanolic extracts of Chiococca alba in Aedes aegypti biorational management: larvicidal and repellent potential, and selectivity against non-target organisms. Plants, Basel, v. 11, p. 3298, 2022. Disponível em: https://doi.org/10.3390/plants11233298. Acesso em: 9 out. 2024.
url https://www.mdpi.com/2223-7747/11/23/3298
http://repositorio.ufla.br/jspui/handle/1/59558
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv Plants
reponame:Repositório Institucional da UFLA
instname:Universidade Federal de Lavras (UFLA)
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instname_str Universidade Federal de Lavras (UFLA)
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institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
repository.name.fl_str_mv Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)
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