Effects of carprofen administered by different routes to control experimental uveitis in dogs

Detalhes bibliográficos
Autor(a) principal: Ribeiro,A.P.
Data de Publicação: 2010
Outros Autores: Escobar,A., Motheo,T.F., Sakamoto,C.A.M., Godoy,G.S., Costa,M.A.N., Laus,J.L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivo brasileiro de medicina veterinária e zootecnia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200010
Resumo: Efficacy of carprofen, administered by different routes, was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval between them. At M0 and M1, 0.2mL of aqueous humor was collected and quantitation of total protein and prostaglandin E2 (PGE2) were determined. Four groups were formed (n=8), which received carprofen at the end of M0, by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII animals was performed. In all groups, values of protein and PGE2 significantly enhanced at M1; however, they did not significantly change among groups at M1. Inflammatory exudate of acute character and mild hemorrhage were seen at histopathology after carprofen administration. Carprofen was unable to inhibit PGE2 synthesis and the protein influx to the anterior chamber by any of the tested routes. However, the reduction of 44% in protein levels (topical) suggests that the agent can be used by this route as an adjuvant to control uveitis in dogs.
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spelling Effects of carprofen administered by different routes to control experimental uveitis in dogsdoguveitiscarprofentotal proteinprostaglandin E2Efficacy of carprofen, administered by different routes, was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval between them. At M0 and M1, 0.2mL of aqueous humor was collected and quantitation of total protein and prostaglandin E2 (PGE2) were determined. Four groups were formed (n=8), which received carprofen at the end of M0, by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII animals was performed. In all groups, values of protein and PGE2 significantly enhanced at M1; however, they did not significantly change among groups at M1. Inflammatory exudate of acute character and mild hemorrhage were seen at histopathology after carprofen administration. Carprofen was unable to inhibit PGE2 synthesis and the protein influx to the anterior chamber by any of the tested routes. However, the reduction of 44% in protein levels (topical) suggests that the agent can be used by this route as an adjuvant to control uveitis in dogs.Universidade Federal de Minas Gerais, Escola de Veterinária2010-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200010Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.62 n.2 2010reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/S0102-09352010000200010info:eu-repo/semantics/openAccessRibeiro,A.P.Escobar,A.Motheo,T.F.Sakamoto,C.A.M.Godoy,G.S.Costa,M.A.N.Laus,J.L.eng2010-05-03T00:00:00Zoai:scielo:S0102-09352010000200010Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2010-05-03T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Effects of carprofen administered by different routes to control experimental uveitis in dogs
title Effects of carprofen administered by different routes to control experimental uveitis in dogs
spellingShingle Effects of carprofen administered by different routes to control experimental uveitis in dogs
Ribeiro,A.P.
dog
uveitis
carprofen
total protein
prostaglandin E2
title_short Effects of carprofen administered by different routes to control experimental uveitis in dogs
title_full Effects of carprofen administered by different routes to control experimental uveitis in dogs
title_fullStr Effects of carprofen administered by different routes to control experimental uveitis in dogs
title_full_unstemmed Effects of carprofen administered by different routes to control experimental uveitis in dogs
title_sort Effects of carprofen administered by different routes to control experimental uveitis in dogs
author Ribeiro,A.P.
author_facet Ribeiro,A.P.
Escobar,A.
Motheo,T.F.
Sakamoto,C.A.M.
Godoy,G.S.
Costa,M.A.N.
Laus,J.L.
author_role author
author2 Escobar,A.
Motheo,T.F.
Sakamoto,C.A.M.
Godoy,G.S.
Costa,M.A.N.
Laus,J.L.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro,A.P.
Escobar,A.
Motheo,T.F.
Sakamoto,C.A.M.
Godoy,G.S.
Costa,M.A.N.
Laus,J.L.
dc.subject.por.fl_str_mv dog
uveitis
carprofen
total protein
prostaglandin E2
topic dog
uveitis
carprofen
total protein
prostaglandin E2
description Efficacy of carprofen, administered by different routes, was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval between them. At M0 and M1, 0.2mL of aqueous humor was collected and quantitation of total protein and prostaglandin E2 (PGE2) were determined. Four groups were formed (n=8), which received carprofen at the end of M0, by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII animals was performed. In all groups, values of protein and PGE2 significantly enhanced at M1; however, they did not significantly change among groups at M1. Inflammatory exudate of acute character and mild hemorrhage were seen at histopathology after carprofen administration. Carprofen was unable to inhibit PGE2 synthesis and the protein influx to the anterior chamber by any of the tested routes. However, the reduction of 44% in protein levels (topical) suggests that the agent can be used by this route as an adjuvant to control uveitis in dogs.
publishDate 2010
dc.date.none.fl_str_mv 2010-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-09352010000200010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
dc.source.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.62 n.2 2010
reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Arquivo brasileiro de medicina veterinária e zootecnia (Online)
collection Arquivo brasileiro de medicina veterinária e zootecnia (Online)
repository.name.fl_str_mv Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br
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