Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter?
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1590/0102-311X00002220 http://hdl.handle.net/1843/66329 http://orcid.org/0000-0002-3109-1342 http://orcid.org/0000-0002-9814-3004 http://orcid.org/0000-0001-7199-8590 http://orcid.org/0000-0002-5228-8822 http://orcid.org/0000-0001-5622-567X |
Resumo: | This study aims to evaluate changes in quality of life of cancer patients at the beginning of the first and the second cycle of chemotherapy (CT) in hospitals in Belo Horizonte, Minas Gerais State, Brazil. Longitudinal, prospective, descriptive study with a quantitative approach. We enrolled 230 patients, from a broader cohort, diagnosed with the five most frequent types of cancer (breast, colorectal, cervical, lung, and head and neck), aged 18 years or older, who were initiating CT for the first time. quality of life was assessed with the EORTC QLQ-C30 version 3, applied at the beginning of the first and second chemotherapy cycle. The paired Wilcoxon test was used to identify differences in quality of life between the two time points. A multivariate linear regression analysis was performed using the bootstrap method to investigate potential predictors of global health Status/quality of life. There was a significant increase in patients’ emotional function scores (p < 0.001) as well as symptom scores for pain (p = 0.026), diarrhea (p = 0.018), and nausea/vomiting (p < 0.001) after initiation of CT. Widowhood was associated with improvements in the global health Status/quality of life (p = 0.028), whereas the presence of cervical cancer (p = 0.034) and being underweight (p = 0.033) were related to poorer global health status/quality of life scores. CT has detrimental effects on patients’ physical health but, on the other hand, it leads to improvements in the emotional domain. Patients’ individual characteristics at the beginning of CT are associated with changes in their quality of life. Our study could help identify these characteristics. |
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2024-03-21T14:24:12Z2024-03-21T14:24:12Z2021378https://doi.org/10.1590/0102-311X000022201678-4464http://hdl.handle.net/1843/66329http://orcid.org/0000-0002-3109-1342http://orcid.org/0000-0002-9814-3004http://orcid.org/0000-0001-7199-8590http://orcid.org/0000-0002-5228-8822http://orcid.org/0000-0001-5622-567XThis study aims to evaluate changes in quality of life of cancer patients at the beginning of the first and the second cycle of chemotherapy (CT) in hospitals in Belo Horizonte, Minas Gerais State, Brazil. Longitudinal, prospective, descriptive study with a quantitative approach. We enrolled 230 patients, from a broader cohort, diagnosed with the five most frequent types of cancer (breast, colorectal, cervical, lung, and head and neck), aged 18 years or older, who were initiating CT for the first time. quality of life was assessed with the EORTC QLQ-C30 version 3, applied at the beginning of the first and second chemotherapy cycle. The paired Wilcoxon test was used to identify differences in quality of life between the two time points. A multivariate linear regression analysis was performed using the bootstrap method to investigate potential predictors of global health Status/quality of life. There was a significant increase in patients’ emotional function scores (p < 0.001) as well as symptom scores for pain (p = 0.026), diarrhea (p = 0.018), and nausea/vomiting (p < 0.001) after initiation of CT. Widowhood was associated with improvements in the global health Status/quality of life (p = 0.028), whereas the presence of cervical cancer (p = 0.034) and being underweight (p = 0.033) were related to poorer global health status/quality of life scores. CT has detrimental effects on patients’ physical health but, on the other hand, it leads to improvements in the emotional domain. Patients’ individual characteristics at the beginning of CT are associated with changes in their quality of life. Our study could help identify these characteristics.O estudo teve como objetivo avaliar as mudanças na qualidade de vida de pacientes oncológicos no início do primeiro e segundo ciclos de quimioterapia (QT) em hospitais em Belo Horizonte, Minas Gerais, Brasil. Foi realizado um estudo descritivo, prospectivo e longitudinal com uma abordagem quantitativa. Arrolamos 230 pacientes de uma coorte maior, diagnosticados com os cinco tipos de câncer mais frequentes (mama, colorretal, colo uterino, pulmão e cabeça e pescoço), com idade 18 anos ou mais e que estavam no início da QT. A qualidade de vida foi avaliada com o EORTC QLQ-C30, versão 3, aplicado no início do primeiro e segundo ciclos de QT. O teste pareado de Wilcoxon foi utilizado para identificar diferenças na qualidade de vida entre os dois momentos. Para investigar potenciais preditores de estado de saúde global/qualidade de vida, foi realizada uma análise de regressão linear multivariada com o método bootstrap. Houve um aumento significativo na pontuação da função emocional dos pacientes (p < 0,001) e de dor (p = 0,026), diarreia (p = 0,018) e náusea/vômito (p < 0,001) após o início da quimioterapia. Estado civil “viúvo/a” esteve associado a melhoras no estado de saúde global/qualidade de vida (p = 0,028), enquanto presença de câncer do colo uterino (p = 0,034) e baixo peso (p = 0,033) estiveram relacionados a piores resultados no estado de saúde global/qualidade de vida. A QT tem efeitos deletérios na saúde física dos pacientes, mas leva a melhorias no domínio emocional. As características individuais dos pacientes no início da QT estão associadas a mudanças na qualidade vida. Nosso estudo pode ajudar a identificar essas características.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilENF - DEPARTAMENTO DE ENFERMAGEM BÁSICAICX - DEPARTAMENTO DE ESTATÍSTICAMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIALCadernos de Saúde PúblicaNeoplasiasQualidade de vidaTratamento farmacológicoPerfil de saúdeCitotoxinasNeoplasmsQuality of lifeDrug therapyHealth profileCytotoxinsQuality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter?Qualidade de vida de pacientes com câncer submetidos a quimioterapia em hospitais em Belo Horizonte, Minas Gerais, Brasil: as características individuais importam?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/csp/a/8PGGJM3YBdykRjDsKR8yTPg/?lang=en#Daniela Pena MoreiraGiovana Paula Rezende SiminoIlka Afonso ReisMarcos Antonio da Cunha SantosMariangela Leal Cherchigliainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/66329/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALQuality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil_ does individual characteristics matter_.pdfQuality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil_ does individual characteristics matter_.pdfapplication/pdf422348https://repositorio.ufmg.br/bitstream/1843/66329/2/Quality%20of%20life%20of%20patients%20with%20cancer%20undergoing%20chemotherapy%20in%20hospitals%20in%20Belo%20Horizonte%2c%20Minas%20Gerais%20State%2c%20Brazil_%20does%20individual%20characteristics%20matter_.pdffd09bd833721fd668e0fd33e37799002MD521843/663292024-03-21 11:24:12.399oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-03-21T14:24:12Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter? |
dc.title.alternative.pt_BR.fl_str_mv |
Qualidade de vida de pacientes com câncer submetidos a quimioterapia em hospitais em Belo Horizonte, Minas Gerais, Brasil: as características individuais importam? |
title |
Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter? |
spellingShingle |
Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter? Daniela Pena Moreira Neoplasms Quality of life Drug therapy Health profile Cytotoxins Neoplasias Qualidade de vida Tratamento farmacológico Perfil de saúde Citotoxinas |
title_short |
Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter? |
title_full |
Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter? |
title_fullStr |
Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter? |
title_full_unstemmed |
Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter? |
title_sort |
Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter? |
author |
Daniela Pena Moreira |
author_facet |
Daniela Pena Moreira Giovana Paula Rezende Simino Ilka Afonso Reis Marcos Antonio da Cunha Santos Mariangela Leal Cherchiglia |
author_role |
author |
author2 |
Giovana Paula Rezende Simino Ilka Afonso Reis Marcos Antonio da Cunha Santos Mariangela Leal Cherchiglia |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Daniela Pena Moreira Giovana Paula Rezende Simino Ilka Afonso Reis Marcos Antonio da Cunha Santos Mariangela Leal Cherchiglia |
dc.subject.por.fl_str_mv |
Neoplasms Quality of life Drug therapy Health profile Cytotoxins |
topic |
Neoplasms Quality of life Drug therapy Health profile Cytotoxins Neoplasias Qualidade de vida Tratamento farmacológico Perfil de saúde Citotoxinas |
dc.subject.other.pt_BR.fl_str_mv |
Neoplasias Qualidade de vida Tratamento farmacológico Perfil de saúde Citotoxinas |
description |
This study aims to evaluate changes in quality of life of cancer patients at the beginning of the first and the second cycle of chemotherapy (CT) in hospitals in Belo Horizonte, Minas Gerais State, Brazil. Longitudinal, prospective, descriptive study with a quantitative approach. We enrolled 230 patients, from a broader cohort, diagnosed with the five most frequent types of cancer (breast, colorectal, cervical, lung, and head and neck), aged 18 years or older, who were initiating CT for the first time. quality of life was assessed with the EORTC QLQ-C30 version 3, applied at the beginning of the first and second chemotherapy cycle. The paired Wilcoxon test was used to identify differences in quality of life between the two time points. A multivariate linear regression analysis was performed using the bootstrap method to investigate potential predictors of global health Status/quality of life. There was a significant increase in patients’ emotional function scores (p < 0.001) as well as symptom scores for pain (p = 0.026), diarrhea (p = 0.018), and nausea/vomiting (p < 0.001) after initiation of CT. Widowhood was associated with improvements in the global health Status/quality of life (p = 0.028), whereas the presence of cervical cancer (p = 0.034) and being underweight (p = 0.033) were related to poorer global health status/quality of life scores. CT has detrimental effects on patients’ physical health but, on the other hand, it leads to improvements in the emotional domain. Patients’ individual characteristics at the beginning of CT are associated with changes in their quality of life. Our study could help identify these characteristics. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2024-03-21T14:24:12Z |
dc.date.available.fl_str_mv |
2024-03-21T14:24:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/66329 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1590/0102-311X00002220 |
dc.identifier.issn.pt_BR.fl_str_mv |
1678-4464 |
dc.identifier.orcid.pt_BR.fl_str_mv |
http://orcid.org/0000-0002-3109-1342 http://orcid.org/0000-0002-9814-3004 http://orcid.org/0000-0001-7199-8590 http://orcid.org/0000-0002-5228-8822 http://orcid.org/0000-0001-5622-567X |
url |
https://doi.org/10.1590/0102-311X00002220 http://hdl.handle.net/1843/66329 http://orcid.org/0000-0002-3109-1342 http://orcid.org/0000-0002-9814-3004 http://orcid.org/0000-0001-7199-8590 http://orcid.org/0000-0002-5228-8822 http://orcid.org/0000-0001-5622-567X |
identifier_str_mv |
1678-4464 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Cadernos de Saúde Pública |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ENF - DEPARTAMENTO DE ENFERMAGEM BÁSICA ICX - DEPARTAMENTO DE ESTATÍSTICA MED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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