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Simone Odília Antunes Fernandeshttp://lattes.cnpq.br/3333466607118191Valbert Nascimento CardosoValbert Nascimento CardosoLuiz Gonzaga Vaz CoelhoFrancisco Guilherme Cancela e Pennahttps://lattes.cnpq.br/2158607831948183Larissa Gabriela Ferreira de Carvalho2023-02-02T17:09:20Z2023-02-02T17:09:20Z2022-09-28http://hdl.handle.net/1843/494750000-0002-9134-9536As doenças inflamatórias intestinais (DIIs), como a doença de Crohn (DC) e a colite ulcerativa (CU), são doenças graves do trato digestivo. O diagnóstico e acompanhamento das DIIs permanece sendo um grande desafio na prática clínica. O objetivo deste estudo foi investigar os níveis séricos da adipocina leptina e calprotectina fecal nos pacientes portadores da doença de crohn (DC). Os valores de leptina sérica e calprotectina fecal, considerado o “padrão-ouro”, foram analisados para identificar uma correlação entre essas proteínas com a atividade da doença (inflamação). Para título de comparação, um grupo controle contendo participantes (n = 8) sem a doença de Crohn, também foi avaliado seguindo os mesmos critérios de coleta e avaliação das amostras. Foram selecionados 15 pacientes com a doença de Crohn. Os níveis séricos de leptina e calprotectina não se mostraram influenciáveis pelo fator gênero em pacientes tão pouco para controles. A leptina não foi capaz de diferenciar a atividade da doença (8,1 (1,30 - 13,40) ng/mL – doença ativa ng/mL; 8 (3,125 - 15,35) ng/mL– doença ativa; p = 0,614), ao contrário da calprotectina que se mostrou mais alta nos pacientes com a doença ativa, 514 (224 - 1231) mcg/g (remissão 145,50 (59,50 - 387,50) mcg/g), p = 0,039. A leptina se mostrou positivamente influenciada pelos valores antropométricos (gordura corporal e circunferência abdominal). Este trabalho mostrou que a leptina tem baixa especificidade e seletividade para diferenciar as formas da doença de Crohn. Com relação ao estágio da doença, apenas a calprotectina mostrou ser eficiente na diferenciação de doença ativa de doença em remissão.Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), are serious diseases of the digestive tract. The diagnosis and follow-up of IBDs remains a major challenge in clinical practice. The aim of this study was to investigate the serum levels of the adipokine leptin and fecal calprotectin in patients with Crohn's disease (CD). Serum leptin and fecal calprotectin values, considered the “gold standard”, were analyzed to identify a correlation between these proteins and disease activity (inflammation). For comparison purposes, a control group containing participants (n = 8) without Crohn's disease was also evaluated following the same criteria for collecting and evaluating the samples. Fifteen patients with Crohn's disease were selected. Serum levels of leptin and calprotectin were not influenced by the gender factor in patients, nor were they influenced by controls. Leptin was not able to differentiate the disease activity (8.1 (1.30 - 13.40) ng/mL – active disease ng/mL; 8 (3.125 - 15.35) ng/mL – active disease; p = 0.614), unlike calprotectin, which was higher in patients with active disease, 514 (224 - 1231) mcg/g (remission 145.50 (59.50 - 387.50) mcg/g), p = 0.039. Leptin was positively influenced by anthropometric values (body fat and waist circumference). This work showed that leptin has low specificity and selectivity for differentiating forms of Crohn's disease. Regarding the stage of the disease, only calprotectin proved to be efficient in differentiating active disease from disease in remission.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorporUniversidade Federal de Minas GeraisPrograma de Pós-Graduação em Ciências FarmacêuticasUFMGBrasilFARMACIA - FACULDADE DE FARMACIADoença de crohnBiomarcadoresLeptinaCalprotectinaDiagnósticoDoenças inflamatórias intestinaisInflamaçãoLeptina sérica, calprotectina fecal e composição corporal em pacientes com doença de Crohn.Serum leptin, fecal calprotectin and body composition in patients with Crohn's disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALLeptina sérica, calprotectina fecal e composição corporal em pacientes com doença de crohn.pdfLeptina sérica, calprotectina fecal e composição corporal em pacientes com doença de crohn.pdfapplication/pdf1873218https://repositorio.ufmg.br/bitstream/1843/49475/3/Leptina%20s%c3%a9rica%2c%20calprotectina%20fecal%20e%20composi%c3%a7%c3%a3o%20corporal%20em%20pacientes%20com%20doen%c3%a7a%20de%20crohn.pdf0b2d371725a858360f8cccd10c0d68f9MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-82118https://repositorio.ufmg.br/bitstream/1843/49475/4/license.txtcda590c95a0b51b4d15f60c9642ca272MD541843/494752023-02-02 14:09:21.158oai:repositorio.ufmg.br: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ório InstitucionalPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-02-02T17:09:21Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
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