Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.msec.2016.03.103 http://hdl.handle.net/1843/49151 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
id |
UFMG_67a89a28b7727431b80fca1fdd636cc4 |
---|---|
oai_identifier_str |
oai:repositorio.ufmg.br:1843/49151 |
network_acronym_str |
UFMG |
network_name_str |
Repositório Institucional da UFMG |
repository_id_str |
|
spelling |
2023-01-25T21:42:10Z2023-01-25T21:42:10Z2016-0764370375https://doi.org/10.1016/j.msec.2016.03.10323276053http://hdl.handle.net/1843/49151CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)Composites of biodegradable polymers and calcium phosphate are bioactive and flexible, and have been proposed for use in tissue engineering and bone regeneration. When associated with the broad-spectrum antibiotic doxycycline (DOX), they could favor antimicrobial action and enhance the action of osteogenic composites. Composites of polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), and a bioceramic of biphasic calcium phosphate Osteosynt® (BCP) were loaded with DOX encapsulated in β-cyclodextrin (βCD) and were evaluated for effects on osteoblastic cell cultures. The DOX/βCD composite was prepared with a double mixing method. Osteoblast viability was assessed with methyl tetrazolium (MTT) assays after 1day, 7day, and 14days of composite exposure; alkaline phosphatase (AP) activity and collagen production were evaluated after 7days and 14days, and mineral nodule formation after 14days. Composite structures were evaluated by scanning electron microscopy (SEM). Osteoblasts exposed to the composite containing 25μg/mL DOX/βCD had increased cell proliferation (p<0.05) compared to control osteoblast cultures at all experimental time points, reaching a maximum in the second week. AP activity and collagen secretion levels were also elevated in osteoblasts exposed to the DOX/βCD composite (p<0.05 vs. controls) and reached a maximum after 14days. These results were corroborated by Von Kossa test results, which showed strong formation of mineralization nodules during the same time period. SEM of the composite material revealed a surface topography with pore sizes suitable for growing osteoblasts. Together, these results suggest that osteoblasts are viable, proliferative, and osteogenic in the presence of a DOX/βCD-containing BCP ceramic compositeengUniversidade Federal de Minas GeraisUFMGBrasilFAO - FACULDADE DE ODONTOLOGIAJournal of Materials Science and Chemical EngineeringDoxycyclinePolymersCyclodextrinsCompomersPeriodonticsOsteoblastsb-cyclodextrindoxycyclinePolymersCompositePeriodontal therapyOsteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga compositeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0928493116302910?via%3DihubVivianne Carvalho da Cunha TrajanoMaria Esperanza Cortés SeguraRuben Dario SinisterraCélia Regina LanzaCostaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/49151/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALOsteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite.pdfOsteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite.pdfapplication/pdf950667https://repositorio.ufmg.br/bitstream/1843/49151/2/Osteogenic%20activity%20of%20cyclodextrin-encapsulated%20doxycycline%20in%20a%20calcium%20phosphate%20pcl%20and%20plga%20composite.pdf20fa4a56c7f0870828157d95e6f1015fMD521843/491512023-01-25 18:42:10.932oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-01-25T21:42:10Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite |
title |
Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite |
spellingShingle |
Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite Vivianne Carvalho da Cunha Trajano b-cyclodextrin doxycycline Polymers Composite Periodontal therapy Doxycycline Polymers Cyclodextrins Compomers Periodontics Osteoblasts |
title_short |
Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite |
title_full |
Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite |
title_fullStr |
Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite |
title_full_unstemmed |
Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite |
title_sort |
Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate pcl and plga composite |
author |
Vivianne Carvalho da Cunha Trajano |
author_facet |
Vivianne Carvalho da Cunha Trajano Maria Esperanza Cortés Segura Ruben Dario Sinisterra Célia Regina Lanza Costa |
author_role |
author |
author2 |
Maria Esperanza Cortés Segura Ruben Dario Sinisterra Célia Regina Lanza Costa |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vivianne Carvalho da Cunha Trajano Maria Esperanza Cortés Segura Ruben Dario Sinisterra Célia Regina Lanza Costa |
dc.subject.por.fl_str_mv |
b-cyclodextrin doxycycline Polymers Composite Periodontal therapy |
topic |
b-cyclodextrin doxycycline Polymers Composite Periodontal therapy Doxycycline Polymers Cyclodextrins Compomers Periodontics Osteoblasts |
dc.subject.other.pt_BR.fl_str_mv |
Doxycycline Polymers Cyclodextrins Compomers Periodontics Osteoblasts |
description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-07 |
dc.date.accessioned.fl_str_mv |
2023-01-25T21:42:10Z |
dc.date.available.fl_str_mv |
2023-01-25T21:42:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/49151 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.msec.2016.03.103 |
dc.identifier.issn.pt_BR.fl_str_mv |
23276053 |
url |
https://doi.org/10.1016/j.msec.2016.03.103 http://hdl.handle.net/1843/49151 |
identifier_str_mv |
23276053 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of Materials Science and Chemical Engineering |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
FAO - FACULDADE DE ODONTOLOGIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Repositório Institucional da UFMG |
collection |
Repositório Institucional da UFMG |
bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/49151/1/License.txt https://repositorio.ufmg.br/bitstream/1843/49151/2/Osteogenic%20activity%20of%20cyclodextrin-encapsulated%20doxycycline%20in%20a%20calcium%20phosphate%20pcl%20and%20plga%20composite.pdf |
bitstream.checksum.fl_str_mv |
fa505098d172de0bc8864fc1287ffe22 20fa4a56c7f0870828157d95e6f1015f |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
|
_version_ |
1803589425070866432 |