Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.21577/0100-4042.20170591 http://hdl.handle.net/1843/47108 https://orcid.org/0000-0002-8885-6625 https://orcid.org/0000-0001-7425-2604 https://orcid.org/0000-0002-0625-6619 https://orcid.org/0000-0002-8171-8035 https://orcid.org/0000-0001-6454-8946 https://orcid.org/0000-0003-1600-7621 https://orcid.org/0000-0002-7765-9853 https://orcid.org/0000-0003-4682-397X https://orcid.org/0000-0001-8562-8689 https://orcid.org/0000-0003-1014-8132 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-11-09T23:19:31Z2022-11-09T23:19:31Z202043810661073https://doi.org/10.21577/0100-4042.201705910100-4042http://hdl.handle.net/1843/47108https://orcid.org/0000-0002-8885-6625https://orcid.org/0000-0001-7425-2604https://orcid.org/0000-0002-0625-6619https://orcid.org/0000-0002-8171-8035https://orcid.org/0000-0001-6454-8946https://orcid.org/0000-0003-1600-7621https://orcid.org/0000-0002-7765-9853https://orcid.org/0000-0003-4682-397Xhttps://orcid.org/0000-0001-8562-8689https://orcid.org/0000-0003-1014-8132CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorMaytenus distichophylla is a medicinal species used in Northeast of Brazil. The hexane (HE), chloroform (CE), ethyl acetate (EAE) and methanol (ME) extracts and compounds from its roots were evaluated for their protective activity against Staphylococcus aureus and Candida albicans. The cytotoxicity for chronic myeloid leukemia (K562), acute monocytic leukemia (THP-1), and peripheral blood mononuclear cells of normal individuals (PBMC) cells was established by MTT method using etoposide as standard. The in vivo toxicity of samples was determined using Caenorhabditis elegans model. From HE and CE were isolated: friedelan-3-one (1), b-sitosterol (2), 3-oxo-olean-9(11),12-diene (3), a mixture of pristimerin (4) and 11a-hydroxylup-20(29)-en-3-one (5), 30-hydroxylup-20(29)-en-3-one (6), friedelane-3,7-dione (7), tingenone (8) and triacylglycerol (9). The structures of 1-9 were confirmed by spectral data. All samples reduced the viability of S. aureus and present no effect against C. albicans. The HE, CE, mixture of 4/5 and 8 reduced 75% of S. aureus viability. Cytotoxic effect for K562 and THP-1 cells was caused by compounds 1, 2 and 8. All samples displayed selectivity for leukemic cells and low toxicity to PBMC cells, suggesting their potential as anticancer agents. Extracts and compounds were non-toxic to L1 larvae of C. elegans. However, most of them reduced significantly young adult worm’s survival, being considered as potential nematicides.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE MICROBIOLOGIAICX - DEPARTAMENTO DE QUÍMICAQuímica NovaCelastraceaeTerpeniosMaytenusLeucemiaCitotoxidade de mediação celularCelastraceaePentacyclic triterpenesToxicityK562 cellsTHP-1 cellsMaytenus distichophyllaLeukemiaCytotoxicityConstituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegansinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/qn/a/wsCkNh5MJdfJC5wXSngZqbJ/#Shirley Alejandra Torres MoralesViviane de Souza AlvesSidney Augusto Vieira FilhoRafael Cesar Gonçalves PereiraLucienir Pains DuarteGrasiely Faria de SousaDjalma Menezes de OliveiraFernanda Cristina Gontijo EvangelistaAdriano de Paula SabinoRoberta Oliveira VianaMariana Guerra de Aguilarapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/47108/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALCONSTITUENTS FROM ROOTS OF Maytenus distichophylla, ANTIMICROBIAL ACTIVITY AND TOXICITY FOR.pdfCONSTITUENTS FROM ROOTS OF Maytenus distichophylla, ANTIMICROBIAL ACTIVITY AND TOXICITY FOR.pdfapplication/pdf812038https://repositorio.ufmg.br/bitstream/1843/47108/2/CONSTITUENTS%20FROM%20ROOTS%20OF%20Maytenus%20distichophylla%2c%20ANTIMICROBIAL%20ACTIVITY%20AND%20TOXICITY%20FOR.pdf631a3f07bb9141a57c16520b3b10b2dbMD521843/471082022-11-09 20:19:32.947oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-11-09T23:19:32Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans |
| title |
Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans |
| spellingShingle |
Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans Shirley Alejandra Torres Morales Celastraceae Pentacyclic triterpenes Toxicity K562 cells THP-1 cells Maytenus distichophylla Leukemia Cytotoxicity Celastraceae Terpenios Maytenus Leucemia Citotoxidade de mediação celular |
| title_short |
Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans |
| title_full |
Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans |
| title_fullStr |
Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans |
| title_full_unstemmed |
Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans |
| title_sort |
Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans |
| author |
Shirley Alejandra Torres Morales |
| author_facet |
Shirley Alejandra Torres Morales Viviane de Souza Alves Sidney Augusto Vieira Filho Rafael Cesar Gonçalves Pereira Lucienir Pains Duarte Grasiely Faria de Sousa Djalma Menezes de Oliveira Fernanda Cristina Gontijo Evangelista Adriano de Paula Sabino Roberta Oliveira Viana Mariana Guerra de Aguilar |
| author_role |
author |
| author2 |
Viviane de Souza Alves Sidney Augusto Vieira Filho Rafael Cesar Gonçalves Pereira Lucienir Pains Duarte Grasiely Faria de Sousa Djalma Menezes de Oliveira Fernanda Cristina Gontijo Evangelista Adriano de Paula Sabino Roberta Oliveira Viana Mariana Guerra de Aguilar |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Shirley Alejandra Torres Morales Viviane de Souza Alves Sidney Augusto Vieira Filho Rafael Cesar Gonçalves Pereira Lucienir Pains Duarte Grasiely Faria de Sousa Djalma Menezes de Oliveira Fernanda Cristina Gontijo Evangelista Adriano de Paula Sabino Roberta Oliveira Viana Mariana Guerra de Aguilar |
| dc.subject.por.fl_str_mv |
Celastraceae Pentacyclic triterpenes Toxicity K562 cells THP-1 cells Maytenus distichophylla Leukemia Cytotoxicity |
| topic |
Celastraceae Pentacyclic triterpenes Toxicity K562 cells THP-1 cells Maytenus distichophylla Leukemia Cytotoxicity Celastraceae Terpenios Maytenus Leucemia Citotoxidade de mediação celular |
| dc.subject.other.pt_BR.fl_str_mv |
Celastraceae Terpenios Maytenus Leucemia Citotoxidade de mediação celular |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2020 |
| dc.date.issued.fl_str_mv |
2020 |
| dc.date.accessioned.fl_str_mv |
2022-11-09T23:19:31Z |
| dc.date.available.fl_str_mv |
2022-11-09T23:19:31Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/47108 |
| dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.21577/0100-4042.20170591 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0100-4042 |
| dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-8885-6625 https://orcid.org/0000-0001-7425-2604 https://orcid.org/0000-0002-0625-6619 https://orcid.org/0000-0002-8171-8035 https://orcid.org/0000-0001-6454-8946 https://orcid.org/0000-0003-1600-7621 https://orcid.org/0000-0002-7765-9853 https://orcid.org/0000-0003-4682-397X https://orcid.org/0000-0001-8562-8689 https://orcid.org/0000-0003-1014-8132 |
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https://doi.org/10.21577/0100-4042.20170591 http://hdl.handle.net/1843/47108 https://orcid.org/0000-0002-8885-6625 https://orcid.org/0000-0001-7425-2604 https://orcid.org/0000-0002-0625-6619 https://orcid.org/0000-0002-8171-8035 https://orcid.org/0000-0001-6454-8946 https://orcid.org/0000-0003-1600-7621 https://orcid.org/0000-0002-7765-9853 https://orcid.org/0000-0003-4682-397X https://orcid.org/0000-0001-8562-8689 https://orcid.org/0000-0003-1014-8132 |
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0100-4042 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.pt_BR.fl_str_mv |
Química Nova |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE MICROBIOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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