The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1016/j.lfs.2018.08.034 http://hdl.handle.net/1843/44508 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-08-24T13:33:17Z2022-08-24T13:33:17Z2018-09-15209341348https://doi.org/10.1016/j.lfs.2018.08.0340024-3205http://hdl.handle.net/1843/44508CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorDiabetic cardiomyopathy (DC) describes diabetes-associated changes in the structure and function of myocardium that are not directly linked to other factors such as hypertension. Currently there are some models of DC; however, they take a large time period to mimic key features. In the present study, we investigated the effects of a short-term high-fat/high salt diet (HFHS) treatment on myocardial function and structure, and vascular reactivity in C57BL/6 male mice. After 14 weeks HFHS induced hypertension (MAP = 144.95 ± 16.13 vs 92.90 ± 18.95 mm Hg), low glucose tolerance (AUC = 1049.01 ± 74.79 vs 710.50 ± 52.57 a.u.), decreased insulin sensitivity (AUC = 429.83 ± 35.22 vs 313.67 ± 19.55 a.u.) and increased adiposity (epididymal fat weight 0.96 ± 0.10 vs 0.59 ± 0.06 OW/BW × 102), aspects present in metabolic syndrome. Cardiac evaluation showed diastolic dysfunction (E/A ratio = 1.20 vs 1.90 u.a.) and cardiomyocyte hypertrophy (cardiomyocyte area = 502.82 ± 31.46 vs 385.58 ± 22.11 μm2). Lastly, vascular reactivity was impaired with higher contractile response (136.10 ± 3.49 vs 120.37 ± 5.43%) and lower response to endothelium-dependent vasorelaxation (74.01 ± 4.35 vs 104.84 ± 3.57%). In addition, the diet was able to induce an inward coronary remodeling (vascular total area: SCNS 6185 ± 800.6 vs HFHS 4085 ± 213.7 μm2). Therefore, we conclude that HFHS short-term treatment was able to induce metabolic syndrome-like state, cardiomyopathy and vascular injury working as an important tool to study cardiometabolic diseases.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASLife SciencesSíndrome metabólicaObesidadeMiocárdio - DoençasDiabetesThe usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S002432051830479X?via%3Dihub#!Leônidas das Graças Mendes JúniorLeandro Ceotto Freitas LimaJanaína Ribeiro OliveiraMarcos de Abreu MeloJohn David FeltenbergerIgor Viana BrandiBruna Mara Aparecida CarvalhoAndré Luiz Sena GuimarãesAlfredo Maurício Batista de PaulaCarlos Eduardo Mendes D'AngelisMaria José Campagnole SantosRobson Augusto Souza SantosValdir Andrade BragaSérgio Henrique Sousa Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44508/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALThe usefulness of short-term high-fathigh salt diet as a model of metabolic syndrome in mice.pdfThe usefulness of short-term high-fathigh salt diet as a model of metabolic syndrome in mice.pdfapplication/pdf1043417https://repositorio.ufmg.br/bitstream/1843/44508/2/The%20usefulness%20of%20short-term%20high-fathigh%20salt%20diet%20as%20a%20model%20of%20metabolic%20syndrome%20in%20mice.pdf164de5b83904aa9c2432da9cec4fde81MD521843/445082022-08-24 10:33:17.567oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-24T13:33:17Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice |
| title |
The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice |
| spellingShingle |
The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice Leônidas das Graças Mendes Júnior Síndrome metabólica Obesidade Miocárdio - Doenças Diabetes |
| title_short |
The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice |
| title_full |
The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice |
| title_fullStr |
The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice |
| title_full_unstemmed |
The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice |
| title_sort |
The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice |
| author |
Leônidas das Graças Mendes Júnior |
| author_facet |
Leônidas das Graças Mendes Júnior Leandro Ceotto Freitas Lima Janaína Ribeiro Oliveira Marcos de Abreu Melo John David Feltenberger Igor Viana Brandi Bruna Mara Aparecida Carvalho André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Carlos Eduardo Mendes D'Angelis Maria José Campagnole Santos Robson Augusto Souza Santos Valdir Andrade Braga Sérgio Henrique Sousa Santos |
| author_role |
author |
| author2 |
Leandro Ceotto Freitas Lima Janaína Ribeiro Oliveira Marcos de Abreu Melo John David Feltenberger Igor Viana Brandi Bruna Mara Aparecida Carvalho André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Carlos Eduardo Mendes D'Angelis Maria José Campagnole Santos Robson Augusto Souza Santos Valdir Andrade Braga Sérgio Henrique Sousa Santos |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Leônidas das Graças Mendes Júnior Leandro Ceotto Freitas Lima Janaína Ribeiro Oliveira Marcos de Abreu Melo John David Feltenberger Igor Viana Brandi Bruna Mara Aparecida Carvalho André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Carlos Eduardo Mendes D'Angelis Maria José Campagnole Santos Robson Augusto Souza Santos Valdir Andrade Braga Sérgio Henrique Sousa Santos |
| dc.subject.other.pt_BR.fl_str_mv |
Síndrome metabólica Obesidade Miocárdio - Doenças Diabetes |
| topic |
Síndrome metabólica Obesidade Miocárdio - Doenças Diabetes |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2018 |
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2018-09-15 |
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2022-08-24T13:33:17Z |
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2022-08-24T13:33:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/1843/44508 |
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https://doi.org/10.1016/j.lfs.2018.08.034 |
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0024-3205 |
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https://doi.org/10.1016/j.lfs.2018.08.034 http://hdl.handle.net/1843/44508 |
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0024-3205 |
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eng |
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Life Sciences |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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