Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1016/j.mgene.2019.100553 http://hdl.handle.net/1843/42554 https://orcid.org/ 0000-0001-8980-8599 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-06-20T15:30:44Z2022-06-20T15:30:44Z201920https://doi.org/10.1016/j.mgene.2019.1005532214-5400http://hdl.handle.net/1843/42554https://orcid.org/ 0000-0001-8980-8599CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorLiraglutide, an important pharmacological agent used to improve glycemic status and weight control, has emerged as a therapeutic strategy for hepatic steatosis treatment. Objective: The aim of the present study was to analyze the influence of liraglutide in hepatic steatosis and evaluate the potential target genes involved in the liraglutide action in the hepatic steatosis through a bioin-formatics study. Methods & procedures: We performed an animal study with male mice divided into three groups: standard, high-fat diet and the third group were fed a high-fat diet and treated with liraglutide at a dose of 0.6 mg/kg body weight. Blood parameters (glucose tolerance and insulin sensitivity tests, total cholesterol, high-density lipo-protein-C, triglycerides and glucose levels) were evaluated. mRNA analysis for ACC and FAS were performed.Gene databases, and bioinformatics algorithms were used to generate molecular targets for liraglutide and he-patic steatosis based on in silico investigation. Interactions networks between protein coding were accessed. Results: The present study showed that liraglutide decreased glucose levels, total cholesterol and triglycerides in obese animals as compared to the high-fat-fed obese mice. AKT and RPS6KB1 genes presented higher disease-related connectivity. Interaction Network exhibited a power law behavior in correlation: 0.896; R2: 0.796. Ontological analysis demonstrated different mechanisms associated such as regulation of signaling process. Conclusion: The present study reveals relevant information regarding the liraglutide effects in hepatic steatosis. The liraglutide improved hyperglycemia and attenuated hepatic steatosis in mice fed a high-fat diet.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASMeta GeneFígado gordurosoSíndrome metabólicaObesidadeGenesLiraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S221454001930012XIsabelle Arruda BarbosaAndré Luiz Sena GuimarãesSérgio Henrique Sousa SantosEloá Mangabeira SantosAlanna Fernandes ParaísoPablo Vinicyus Ferreira ChagasLuís Paulo OliveiraJoão Marcus Oliveira AndradeLucyana Conceição FariasBruna Mara Aparecida de Carvalho MesquitaAlfredo Maurício Batista de Paulainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/42554/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALLiraglutide alters hepatic metabolism in high-fat fed obese mice a bioinformatic prediction and functional analysis.pdfLiraglutide alters hepatic metabolism in high-fat fed obese mice a bioinformatic prediction and functional analysis.pdfapplication/pdf3627022https://repositorio.ufmg.br/bitstream/1843/42554/2/Liraglutide%20alters%20hepatic%20metabolism%20in%20high-fat%20fed%20obese%20mice%20a%20bioinformatic%20prediction%20and%20functional%20analysis.pdf78c7c466b8d01c19d6ebc398cde050b0MD521843/425542022-06-20 12:30:45.395oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-06-20T15:30:45Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis |
| title |
Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis |
| spellingShingle |
Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis Isabelle Arruda Barbosa Fígado gorduroso Síndrome metabólica Obesidade Genes |
| title_short |
Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis |
| title_full |
Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis |
| title_fullStr |
Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis |
| title_full_unstemmed |
Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis |
| title_sort |
Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis |
| author |
Isabelle Arruda Barbosa |
| author_facet |
Isabelle Arruda Barbosa André Luiz Sena Guimarães Sérgio Henrique Sousa Santos Eloá Mangabeira Santos Alanna Fernandes Paraíso Pablo Vinicyus Ferreira Chagas Luís Paulo Oliveira João Marcus Oliveira Andrade Lucyana Conceição Farias Bruna Mara Aparecida de Carvalho Mesquita Alfredo Maurício Batista de Paula |
| author_role |
author |
| author2 |
André Luiz Sena Guimarães Sérgio Henrique Sousa Santos Eloá Mangabeira Santos Alanna Fernandes Paraíso Pablo Vinicyus Ferreira Chagas Luís Paulo Oliveira João Marcus Oliveira Andrade Lucyana Conceição Farias Bruna Mara Aparecida de Carvalho Mesquita Alfredo Maurício Batista de Paula |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Isabelle Arruda Barbosa André Luiz Sena Guimarães Sérgio Henrique Sousa Santos Eloá Mangabeira Santos Alanna Fernandes Paraíso Pablo Vinicyus Ferreira Chagas Luís Paulo Oliveira João Marcus Oliveira Andrade Lucyana Conceição Farias Bruna Mara Aparecida de Carvalho Mesquita Alfredo Maurício Batista de Paula |
| dc.subject.other.pt_BR.fl_str_mv |
Fígado gorduroso Síndrome metabólica Obesidade Genes |
| topic |
Fígado gorduroso Síndrome metabólica Obesidade Genes |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2019 |
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2019 |
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2022-06-20T15:30:44Z |
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2022-06-20T15:30:44Z |
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http://hdl.handle.net/1843/42554 |
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https://doi.org/10.1016/j.mgene.2019.100553 |
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2214-5400 |
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https://orcid.org/ 0000-0001-8980-8599 |
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https://doi.org/10.1016/j.mgene.2019.100553 http://hdl.handle.net/1843/42554 https://orcid.org/ 0000-0001-8980-8599 |
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eng |
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Meta Gene |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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