Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.ijdevneu.2017.10.006 http://hdl.handle.net/1843/40931 http://orcid.org/0000-0002-8960-2256 https://orcid.org/ 0000-0003-0074-3034 https://orcid.org/ 0000-0002-9621-5422 https://orcid.org/0000-0001-9222-3882 |
Resumo: | To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β, IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations. |
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2022-04-08T14:47:50Z2022-04-08T14:47:50Z2018-04652937https://doi.org/10.1016/j.ijdevneu.2017.10.0061873-474Xhttp://hdl.handle.net/1843/40931http://orcid.org/0000-0002-8960-2256https://orcid.org/ 0000-0003-0074-3034https://orcid.org/ 0000-0002-9621-5422https://orcid.org/0000-0001-9222-3882To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β, IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations.engUniversidade Federal de Minas GeraisUFMGBrasilEEF - DEPARTAMENTO DE TERAPIA OCUPACIONALMED - DEPARTAMENTO DE PEDIATRIAMED - DEPARTAMENTO DE SAÚDE MENTALInternational Journal of Developmental NeuroscienceInflamaçãoCitocinasDesempenho psicomotorDesenvolvimento cognitivoPrematurosInflammationCytokinesNeurotrophic factorsMotor developmentCognitive developmentPretermInflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://onlinelibrary.wiley.com/doi/full/10.1016/j.ijdevneu.2017.10.006Rafael Coelho MagalhãesLetícia Pereira PimentaIzabela Guimarães BarbosaJanaina Matos MoreiraJoão Luís Vieira Monteiro de BarrosAntonio Lucio TeixeiraAna Cristina Simões e Silvaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/40931/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALInflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates.pdfInflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates.pdfapplication/pdf396038https://repositorio.ufmg.br/bitstream/1843/40931/2/Inflammatory%20molecules%20and%20neurotrophic%20factors%20as%20biomarkers%20of%20neuropsychomotor%20development%20in%20preterm%20neonates.pdf39021027a0856cbd683d06e92599efa8MD521843/409312022-04-08 11:47:50.875oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-04-08T14:47:50Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review |
title |
Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review |
spellingShingle |
Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review Rafael Coelho Magalhães Inflammation Cytokines Neurotrophic factors Motor development Cognitive development Preterm Inflamação Citocinas Desempenho psicomotor Desenvolvimento cognitivo Prematuros |
title_short |
Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review |
title_full |
Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review |
title_fullStr |
Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review |
title_full_unstemmed |
Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review |
title_sort |
Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review |
author |
Rafael Coelho Magalhães |
author_facet |
Rafael Coelho Magalhães Letícia Pereira Pimenta Izabela Guimarães Barbosa Janaina Matos Moreira João Luís Vieira Monteiro de Barros Antonio Lucio Teixeira Ana Cristina Simões e Silva |
author_role |
author |
author2 |
Letícia Pereira Pimenta Izabela Guimarães Barbosa Janaina Matos Moreira João Luís Vieira Monteiro de Barros Antonio Lucio Teixeira Ana Cristina Simões e Silva |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rafael Coelho Magalhães Letícia Pereira Pimenta Izabela Guimarães Barbosa Janaina Matos Moreira João Luís Vieira Monteiro de Barros Antonio Lucio Teixeira Ana Cristina Simões e Silva |
dc.subject.por.fl_str_mv |
Inflammation Cytokines Neurotrophic factors Motor development Cognitive development Preterm |
topic |
Inflammation Cytokines Neurotrophic factors Motor development Cognitive development Preterm Inflamação Citocinas Desempenho psicomotor Desenvolvimento cognitivo Prematuros |
dc.subject.other.pt_BR.fl_str_mv |
Inflamação Citocinas Desempenho psicomotor Desenvolvimento cognitivo Prematuros |
description |
To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β, IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-04 |
dc.date.accessioned.fl_str_mv |
2022-04-08T14:47:50Z |
dc.date.available.fl_str_mv |
2022-04-08T14:47:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/40931 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.ijdevneu.2017.10.006 |
dc.identifier.issn.pt_BR.fl_str_mv |
1873-474X |
dc.identifier.orcid.pt_BR.fl_str_mv |
http://orcid.org/0000-0002-8960-2256 https://orcid.org/ 0000-0003-0074-3034 https://orcid.org/ 0000-0002-9621-5422 https://orcid.org/0000-0001-9222-3882 |
url |
https://doi.org/10.1016/j.ijdevneu.2017.10.006 http://hdl.handle.net/1843/40931 http://orcid.org/0000-0002-8960-2256 https://orcid.org/ 0000-0003-0074-3034 https://orcid.org/ 0000-0002-9621-5422 https://orcid.org/0000-0001-9222-3882 |
identifier_str_mv |
1873-474X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
International Journal of Developmental Neuroscience |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
EEF - DEPARTAMENTO DE TERAPIA OCUPACIONAL MED - DEPARTAMENTO DE PEDIATRIA MED - DEPARTAMENTO DE SAÚDE MENTAL |
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Universidade Federal de Minas Gerais |
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