Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://dx.doi.org/10.21577/0100-4042.20170537 http://hdl.handle.net/1843/56037 https://orcid.org/0000-0003-2451-3436 https://orcid.org/0000-0002-0644-9197 https://orcid.org/0000-0002-1807-971X https://orcid.org/0000-0003-0464-4754 https://orcid.org/0000-0003-2408-3448 |
Resumo: | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
| id |
UFMG_b47ac70ba7e075a39a47292b7de2bb59 |
|---|---|
| oai_identifier_str |
oai:repositorio.ufmg.br:1843/56037 |
| network_acronym_str |
UFMG |
| network_name_str |
Repositório Institucional da UFMG |
| repository_id_str |
|
| spelling |
2023-07-10T19:31:40Z2023-07-10T19:31:40Z2020436685691http://dx.doi.org/10.21577/0100-4042.201705371678-7064http://hdl.handle.net/1843/56037https://orcid.org/0000-0003-2451-3436https://orcid.org/0000-0002-0644-9197https://orcid.org/0000-0002-1807-971Xhttps://orcid.org/0000-0003-0464-4754https://orcid.org/0000-0003-2408-3448FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisThe insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventional or modified released drugs and are designed to be upgraded as drug-modulating controllers at specific sites in the body. Indomethacin has been used in the controlled release of drugs because it is a drug that have good interaction with different polymers. The drug is a non-steroidal anti-inflammatory drug used in the treatment of rheumatoid arthritis, osteoarthritis, spondylitis, and other disorders. In this work, PEG 4000 had its chain modified by organic reactions and their derivatives were emulsified to form microparticles using polyvinyl alcohol as an emulsifier. Posteriorly were also incorporated with indomethacin. The samples were characterized to prove the influence of indomethacin on the morphology and thermal behavior of this polymer. The controlled release was performed in the time from 0 to 240 min using the Ultraviolet Spectroscopy to quantify indomethacin released from the polymer matrix for these 4 hours. Releases over the time were satisfactory as concentrations increased over time, which we can conclude that the structural modification of PEG 4000 was beneficial in the release of the indomethacin drug.engUniversidade Federal de Minas GeraisUFMGBrasilICX - DEPARTAMENTO DE FÍSICAQuímica NovaPolímerosPolyethyleneglycolIndomethacinControlled releaseNovel PEG 4000 derivatives and its use in controlled release of drug indomethacininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://quimicanova.sbq.org.br/detalhe_artigo.asp?id=9089Lubia Guaima NascimentoSuellen Aliani LopesAyron Breno Lima TeodolinoKátia Monteiro NovackAna Paula Moreira BarbozaBernardo Ruegger Almeida NevesMaria Luíza Schaefer AzevedoLucas Resende Dutra SousaViviane Martins Rebello dos Santosapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56037/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALNovel PEG 4000 derivatives and its use in controlled release of drug indomethacin.pdfNovel PEG 4000 derivatives and its use in controlled release of drug indomethacin.pdfapplication/pdf33367669https://repositorio.ufmg.br/bitstream/1843/56037/2/Novel%20PEG%204000%20derivatives%20and%20its%20use%20in%20controlled%20release%20of%20drug%20indomethacin.pdf76381cbf13e6d263a0e08b5ac2dc21f8MD521843/560372023-07-10 17:09:22.807oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-10T20:09:22Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title |
Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| spellingShingle |
Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin Lubia Guaima Nascimento Polyethyleneglycol Indomethacin Controlled release Polímeros |
| title_short |
Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title_full |
Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title_fullStr |
Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title_full_unstemmed |
Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title_sort |
Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| author |
Lubia Guaima Nascimento |
| author_facet |
Lubia Guaima Nascimento Suellen Aliani Lopes Ayron Breno Lima Teodolino Kátia Monteiro Novack Ana Paula Moreira Barboza Bernardo Ruegger Almeida Neves Maria Luíza Schaefer Azevedo Lucas Resende Dutra Sousa Viviane Martins Rebello dos Santos |
| author_role |
author |
| author2 |
Suellen Aliani Lopes Ayron Breno Lima Teodolino Kátia Monteiro Novack Ana Paula Moreira Barboza Bernardo Ruegger Almeida Neves Maria Luíza Schaefer Azevedo Lucas Resende Dutra Sousa Viviane Martins Rebello dos Santos |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lubia Guaima Nascimento Suellen Aliani Lopes Ayron Breno Lima Teodolino Kátia Monteiro Novack Ana Paula Moreira Barboza Bernardo Ruegger Almeida Neves Maria Luíza Schaefer Azevedo Lucas Resende Dutra Sousa Viviane Martins Rebello dos Santos |
| dc.subject.por.fl_str_mv |
Polyethyleneglycol Indomethacin Controlled release |
| topic |
Polyethyleneglycol Indomethacin Controlled release Polímeros |
| dc.subject.other.pt_BR.fl_str_mv |
Polímeros |
| description |
FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
| publishDate |
2020 |
| dc.date.issued.fl_str_mv |
2020 |
| dc.date.accessioned.fl_str_mv |
2023-07-10T19:31:40Z |
| dc.date.available.fl_str_mv |
2023-07-10T19:31:40Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56037 |
| dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.21577/0100-4042.20170537 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1678-7064 |
| dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0003-2451-3436 https://orcid.org/0000-0002-0644-9197 https://orcid.org/0000-0002-1807-971X https://orcid.org/0000-0003-0464-4754 https://orcid.org/0000-0003-2408-3448 |
| url |
http://dx.doi.org/10.21577/0100-4042.20170537 http://hdl.handle.net/1843/56037 https://orcid.org/0000-0003-2451-3436 https://orcid.org/0000-0002-0644-9197 https://orcid.org/0000-0002-1807-971X https://orcid.org/0000-0003-0464-4754 https://orcid.org/0000-0003-2408-3448 |
| identifier_str_mv |
1678-7064 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Química Nova |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
| dc.publisher.initials.fl_str_mv |
UFMG |
| dc.publisher.country.fl_str_mv |
Brasil |
| dc.publisher.department.fl_str_mv |
ICX - DEPARTAMENTO DE FÍSICA |
| publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| instname_str |
Universidade Federal de Minas Gerais (UFMG) |
| instacron_str |
UFMG |
| institution |
UFMG |
| reponame_str |
Repositório Institucional da UFMG |
| collection |
Repositório Institucional da UFMG |
| bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/56037/1/License.txt https://repositorio.ufmg.br/bitstream/1843/56037/2/Novel%20PEG%204000%20derivatives%20and%20its%20use%20in%20controlled%20release%20of%20drug%20indomethacin.pdf |
| bitstream.checksum.fl_str_mv |
fa505098d172de0bc8864fc1287ffe22 76381cbf13e6d263a0e08b5ac2dc21f8 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
| repository.mail.fl_str_mv |
|
| _version_ |
1801676906466115584 |