Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/40631 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-03-30T20:07:51Z2022-03-30T20:07:51Z2018-048210310810.1016/j.jpha.2017.12.00620951779http://hdl.handle.net/1843/40631CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorMeloxicam (MLX) is an anti-inflammatory drug susceptible to variations and crystalline transitions. In compounding pharmacies, the complete crystallographic evaluation of the raw material is not a routine procedure. We performed a complete crystallographic characterization of aleatory raw MLX samples from compounding pharmacies. X-ray diffraction indicated the presence of two crystalline forms in one sample. DSC experiments suggested that crystallization, or a crystal transition, occurred differently between samples. The FTIR and 1H NMR spectra showed characteristic assignments. 13C solid-state NMR spectroscopy indicated the presence of more than one phase in a sample from pharmacy B. The Hirshfeld surface analysis, with electrostatic potential projection, allowed complete assignment of the UV spectra in ethanol solution. The polymorph I of meloxicam was more active than polymorph III in an experimental model of acute inflammation in mice. Our results highlighted the need for complete crystallographic characterization and the separation of freely used raw materials in compounding pharmacies, as a routine procedure, to ensure the desired dose/effect.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ALIMENTOSFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSICX - DEPARTAMENTO DE QUÍMICAJournal of Pharmaceutical AnalysisQuímicaFarmácia de manipulaçãoFarmáciaMeloxicamPolymorphismHirshfeld surfaceAnti-inflammatory activityPhysicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samplesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S2095177917301399Luciana Flávia de Almeida RomaniMaria Irene YoshidaElionai Cassiana de Lima GomesRenes de Resende MachadoFelipe Fernandes RodriguesMárcio de Matos CoelhoMarcelo Antônio de OliveiraMaria Betânia de Freitas-MarquesRosane Aguiar da Silva San GilWagner da Nova Musselapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/40631/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALPhysicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples.pdfPhysicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples.pdfapplication/pdf1614029https://repositorio.ufmg.br/bitstream/1843/40631/2/Physicochemical%20characterization%2c%20the%20Hirshfeld%20surface%2c%20and%20biological%20evaluation%20of%20two%20meloxicam%20compounding%20pharmacy%20samples.pdf74051ad8e08cfd2699f8cbd4bc3ccfc4MD521843/406312022-03-30 17:07:51.879oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-03-30T20:07:51Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples |
title |
Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples |
spellingShingle |
Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples Luciana Flávia de Almeida Romani Meloxicam Polymorphism Hirshfeld surface Anti-inflammatory activity Química Farmácia de manipulação Farmácia |
title_short |
Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples |
title_full |
Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples |
title_fullStr |
Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples |
title_full_unstemmed |
Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples |
title_sort |
Physicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples |
author |
Luciana Flávia de Almeida Romani |
author_facet |
Luciana Flávia de Almeida Romani Maria Irene Yoshida Elionai Cassiana de Lima Gomes Renes de Resende Machado Felipe Fernandes Rodrigues Márcio de Matos Coelho Marcelo Antônio de Oliveira Maria Betânia de Freitas-Marques Rosane Aguiar da Silva San Gil Wagner da Nova Mussel |
author_role |
author |
author2 |
Maria Irene Yoshida Elionai Cassiana de Lima Gomes Renes de Resende Machado Felipe Fernandes Rodrigues Márcio de Matos Coelho Marcelo Antônio de Oliveira Maria Betânia de Freitas-Marques Rosane Aguiar da Silva San Gil Wagner da Nova Mussel |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Luciana Flávia de Almeida Romani Maria Irene Yoshida Elionai Cassiana de Lima Gomes Renes de Resende Machado Felipe Fernandes Rodrigues Márcio de Matos Coelho Marcelo Antônio de Oliveira Maria Betânia de Freitas-Marques Rosane Aguiar da Silva San Gil Wagner da Nova Mussel |
dc.subject.por.fl_str_mv |
Meloxicam Polymorphism Hirshfeld surface Anti-inflammatory activity |
topic |
Meloxicam Polymorphism Hirshfeld surface Anti-inflammatory activity Química Farmácia de manipulação Farmácia |
dc.subject.other.pt_BR.fl_str_mv |
Química Farmácia de manipulação Farmácia |
description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-04 |
dc.date.accessioned.fl_str_mv |
2022-03-30T20:07:51Z |
dc.date.available.fl_str_mv |
2022-03-30T20:07:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/40631 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/j.jpha.2017.12.006 |
dc.identifier.issn.pt_BR.fl_str_mv |
20951779 |
identifier_str_mv |
10.1016/j.jpha.2017.12.006 20951779 |
url |
http://hdl.handle.net/1843/40631 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of Pharmaceutical Analysis |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICX - DEPARTAMENTO DE QUÍMICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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