Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver

Roberta Cristelli Fonseca; Gabriel Shimizu Bassi; Camila Carvalho Brito; Lorena Barreto Rosa; Bruna Araújo David; Alan Moreira Araújo; Natália Nóbrega; Ariane Barros Diniz; Itamar Couto Guedes Jesus; Lucíola Silva Barcelos; Marco Antônio Peliky Fontes; Daniella Bonaventura; Alexandre Kanashiro; Thiago Mattar Cunha; Sílvia Guatimosim; Valbert Nascimento Cardoso; Simone Odília Antunes Fernandes; Gustavo Batista Menezes; Guillaume de Lartigue; André Gustavo Oliveira

Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver

Detalhes bibliográficos
Autor(a) principal:	Roberta Cristelli Fonseca
Data de Publicação:	2019
Outros Autores:	Gabriel Shimizu Bassi, Camila Carvalho Brito, Lorena Barreto Rosa, Bruna Araújo David, Alan Moreira Araújo, Natália Nóbrega, Ariane Barros Diniz, Itamar Couto Guedes Jesus, Lucíola Silva Barcelos, Marco Antônio Peliky Fontes, Daniella Bonaventura, Alexandre Kanashiro, Thiago Mattar Cunha, Sílvia Guatimosim, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Gustavo Batista Menezes, Guillaume de Lartigue, André Gustavo Oliveira
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da UFMG
Texto Completo:	http://hdl.handle.net/1843/40843
Resumo:	CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico

Metadados do item

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spelling	2022-04-06T21:26:56Z2022-04-06T21:26:56Z2019-108144445410.1016/j.bbi.2019.06.0410889-1591http://hdl.handle.net/1843/40843CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorThe gastrointestinal (GI) tract harbors commensal microorganisms as well as invasive bacteria, toxins and other pathogens and, therefore, plays a pivotal barrier and immunological role against pathogenic agents. The vagus nerve is an important regulator of the GI tract-associated immune system, having profound effects on inflammatory responses. Among GI tract organs, the liver is a key site of immune surveillance, as it has a large population of resident macrophages and receives the blood drained from the guts through the hepatic portal circulation. Although it is widely accepted that the hepatic tissue is a major target for vagus nerve fibers, the role of this neural circuit in liver immune functions is still poorly understood. Herein we used in vivo imaging techniques, including confocal microscopy and scintigraphy, to show that vagus nerve stimulation increases the phagocytosis activity by resident macrophages in the liver, even on the absence of an immune challenge. The activation of this neural circuit in a non-lethal model of sepsis optimized the removal of bacteria in the liver and resulted in the production of anti-inflammatory and pro-regenerative cytokines. Our findings provide new insights into the neural regulation of the immune system in the liver.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ALIMENTOSFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE FARMACOLOGIAICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAICB - DEPARTAMENTO DE MORFOLOGIABrain, Behavior, and ImmunityFígadoNervo vagoVagus nerveCholinergic signalingLiverKupffer cellsPhagocytosisVagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liverinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S088915911831225X?via%3DihubRoberta Cristelli FonsecaGabriel Shimizu BassiCamila Carvalho BritoLorena Barreto RosaBruna Araújo DavidAlan Moreira AraújoNatália NóbregaAriane Barros DinizItamar Couto Guedes JesusLucíola Silva BarcelosMarco Antônio Peliky FontesDaniella BonaventuraAlexandre KanashiroThiago Mattar CunhaSílvia GuatimosimValbert Nascimento CardosoSimone Odília Antunes FernandesGustavo Batista MenezesGuillaume de LartigueAndré Gustavo Oliveiraapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/40843/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALVagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver.pdfVagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver.pdfapplication/pdf2911802https://repositorio.ufmg.br/bitstream/1843/40843/2/Vagus%20nerve%20regulates%20the%20phagocytic%20and%20secretory%20activity%20of%20resident%20macrophages%20in%20the%20liver.pdf4fd56a2022944e61f7357854ff9057aaMD521843/408432022-04-06 18:26:57.175oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-04-06T21:26:57Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv	Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
title	Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
spellingShingle	Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver Roberta Cristelli Fonseca Vagus nerve Cholinergic signaling Liver Kupffer cells Phagocytosis Fígado Nervo vago
title_short	Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
title_full	Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
title_fullStr	Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
title_full_unstemmed	Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
title_sort	Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
author	Roberta Cristelli Fonseca
author_facet	Roberta Cristelli Fonseca Gabriel Shimizu Bassi Camila Carvalho Brito Lorena Barreto Rosa Bruna Araújo David Alan Moreira Araújo Natália Nóbrega Ariane Barros Diniz Itamar Couto Guedes Jesus Lucíola Silva Barcelos Marco Antônio Peliky Fontes Daniella Bonaventura Alexandre Kanashiro Thiago Mattar Cunha Sílvia Guatimosim Valbert Nascimento Cardoso Simone Odília Antunes Fernandes Gustavo Batista Menezes Guillaume de Lartigue André Gustavo Oliveira
author_role	author
author2	Gabriel Shimizu Bassi Camila Carvalho Brito Lorena Barreto Rosa Bruna Araújo David Alan Moreira Araújo Natália Nóbrega Ariane Barros Diniz Itamar Couto Guedes Jesus Lucíola Silva Barcelos Marco Antônio Peliky Fontes Daniella Bonaventura Alexandre Kanashiro Thiago Mattar Cunha Sílvia Guatimosim Valbert Nascimento Cardoso Simone Odília Antunes Fernandes Gustavo Batista Menezes Guillaume de Lartigue André Gustavo Oliveira
author2_role	author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Roberta Cristelli Fonseca Gabriel Shimizu Bassi Camila Carvalho Brito Lorena Barreto Rosa Bruna Araújo David Alan Moreira Araújo Natália Nóbrega Ariane Barros Diniz Itamar Couto Guedes Jesus Lucíola Silva Barcelos Marco Antônio Peliky Fontes Daniella Bonaventura Alexandre Kanashiro Thiago Mattar Cunha Sílvia Guatimosim Valbert Nascimento Cardoso Simone Odília Antunes Fernandes Gustavo Batista Menezes Guillaume de Lartigue André Gustavo Oliveira
dc.subject.por.fl_str_mv	Vagus nerve Cholinergic signaling Liver Kupffer cells Phagocytosis
topic	Vagus nerve Cholinergic signaling Liver Kupffer cells Phagocytosis Fígado Nervo vago
dc.subject.other.pt_BR.fl_str_mv	Fígado Nervo vago
description	CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate	2019
dc.date.issued.fl_str_mv	2019-10
dc.date.accessioned.fl_str_mv	2022-04-06T21:26:56Z
dc.date.available.fl_str_mv	2022-04-06T21:26:56Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/1843/40843
dc.identifier.doi.pt_BR.fl_str_mv	10.1016/j.bbi.2019.06.041
dc.identifier.issn.pt_BR.fl_str_mv	0889-1591
identifier_str_mv	10.1016/j.bbi.2019.06.041 0889-1591
url	http://hdl.handle.net/1843/40843
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.ispartof.pt_BR.fl_str_mv	Brain, Behavior, and Immunity
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv	UFMG
dc.publisher.country.fl_str_mv	Brasil
dc.publisher.department.fl_str_mv	FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICB - DEPARTAMENTO DE MORFOLOGIA
publisher.none.fl_str_mv	Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv	reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG
instname_str	Universidade Federal de Minas Gerais (UFMG)
instacron_str	UFMG
institution	UFMG
reponame_str	Repositório Institucional da UFMG
collection	Repositório Institucional da UFMG
bitstream.url.fl_str_mv	https://repositorio.ufmg.br/bitstream/1843/40843/1/License.txt https://repositorio.ufmg.br/bitstream/1843/40843/2/Vagus%20nerve%20regulates%20the%20phagocytic%20and%20secretory%20activity%20of%20resident%20macrophages%20in%20the%20liver.pdf
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repository.name.fl_str_mv	Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv
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Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver

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