Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/40843 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-04-06T21:26:56Z2022-04-06T21:26:56Z2019-108144445410.1016/j.bbi.2019.06.0410889-1591http://hdl.handle.net/1843/40843CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorThe gastrointestinal (GI) tract harbors commensal microorganisms as well as invasive bacteria, toxins and other pathogens and, therefore, plays a pivotal barrier and immunological role against pathogenic agents. The vagus nerve is an important regulator of the GI tract-associated immune system, having profound effects on inflammatory responses. Among GI tract organs, the liver is a key site of immune surveillance, as it has a large population of resident macrophages and receives the blood drained from the guts through the hepatic portal circulation. Although it is widely accepted that the hepatic tissue is a major target for vagus nerve fibers, the role of this neural circuit in liver immune functions is still poorly understood. Herein we used in vivo imaging techniques, including confocal microscopy and scintigraphy, to show that vagus nerve stimulation increases the phagocytosis activity by resident macrophages in the liver, even on the absence of an immune challenge. The activation of this neural circuit in a non-lethal model of sepsis optimized the removal of bacteria in the liver and resulted in the production of anti-inflammatory and pro-regenerative cytokines. Our findings provide new insights into the neural regulation of the immune system in the liver.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ALIMENTOSFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE FARMACOLOGIAICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAICB - DEPARTAMENTO DE MORFOLOGIABrain, Behavior, and ImmunityFígadoNervo vagoVagus nerveCholinergic signalingLiverKupffer cellsPhagocytosisVagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liverinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S088915911831225X?via%3DihubRoberta Cristelli FonsecaGabriel Shimizu BassiCamila Carvalho BritoLorena Barreto RosaBruna Araújo DavidAlan Moreira AraújoNatália NóbregaAriane Barros DinizItamar Couto Guedes JesusLucíola Silva BarcelosMarco Antônio Peliky FontesDaniella BonaventuraAlexandre KanashiroThiago Mattar CunhaSílvia GuatimosimValbert Nascimento CardosoSimone Odília Antunes FernandesGustavo Batista MenezesGuillaume de LartigueAndré Gustavo Oliveiraapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/40843/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALVagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver.pdfVagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver.pdfapplication/pdf2911802https://repositorio.ufmg.br/bitstream/1843/40843/2/Vagus%20nerve%20regulates%20the%20phagocytic%20and%20secretory%20activity%20of%20resident%20macrophages%20in%20the%20liver.pdf4fd56a2022944e61f7357854ff9057aaMD521843/408432022-04-06 18:26:57.175oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-04-06T21:26:57Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver |
title |
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver |
spellingShingle |
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver Roberta Cristelli Fonseca Vagus nerve Cholinergic signaling Liver Kupffer cells Phagocytosis Fígado Nervo vago |
title_short |
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver |
title_full |
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver |
title_fullStr |
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver |
title_full_unstemmed |
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver |
title_sort |
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver |
author |
Roberta Cristelli Fonseca |
author_facet |
Roberta Cristelli Fonseca Gabriel Shimizu Bassi Camila Carvalho Brito Lorena Barreto Rosa Bruna Araújo David Alan Moreira Araújo Natália Nóbrega Ariane Barros Diniz Itamar Couto Guedes Jesus Lucíola Silva Barcelos Marco Antônio Peliky Fontes Daniella Bonaventura Alexandre Kanashiro Thiago Mattar Cunha Sílvia Guatimosim Valbert Nascimento Cardoso Simone Odília Antunes Fernandes Gustavo Batista Menezes Guillaume de Lartigue André Gustavo Oliveira |
author_role |
author |
author2 |
Gabriel Shimizu Bassi Camila Carvalho Brito Lorena Barreto Rosa Bruna Araújo David Alan Moreira Araújo Natália Nóbrega Ariane Barros Diniz Itamar Couto Guedes Jesus Lucíola Silva Barcelos Marco Antônio Peliky Fontes Daniella Bonaventura Alexandre Kanashiro Thiago Mattar Cunha Sílvia Guatimosim Valbert Nascimento Cardoso Simone Odília Antunes Fernandes Gustavo Batista Menezes Guillaume de Lartigue André Gustavo Oliveira |
author2_role |
author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Roberta Cristelli Fonseca Gabriel Shimizu Bassi Camila Carvalho Brito Lorena Barreto Rosa Bruna Araújo David Alan Moreira Araújo Natália Nóbrega Ariane Barros Diniz Itamar Couto Guedes Jesus Lucíola Silva Barcelos Marco Antônio Peliky Fontes Daniella Bonaventura Alexandre Kanashiro Thiago Mattar Cunha Sílvia Guatimosim Valbert Nascimento Cardoso Simone Odília Antunes Fernandes Gustavo Batista Menezes Guillaume de Lartigue André Gustavo Oliveira |
dc.subject.por.fl_str_mv |
Vagus nerve Cholinergic signaling Liver Kupffer cells Phagocytosis |
topic |
Vagus nerve Cholinergic signaling Liver Kupffer cells Phagocytosis Fígado Nervo vago |
dc.subject.other.pt_BR.fl_str_mv |
Fígado Nervo vago |
description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-10 |
dc.date.accessioned.fl_str_mv |
2022-04-06T21:26:56Z |
dc.date.available.fl_str_mv |
2022-04-06T21:26:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/40843 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/j.bbi.2019.06.041 |
dc.identifier.issn.pt_BR.fl_str_mv |
0889-1591 |
identifier_str_mv |
10.1016/j.bbi.2019.06.041 0889-1591 |
url |
http://hdl.handle.net/1843/40843 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brain, Behavior, and Immunity |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICB - DEPARTAMENTO DE MORFOLOGIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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