Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.rbre.2016.09.014 http://hdl.handle.net/1843/57633 |
Resumo: | Background: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators.Objective: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus(SLE).Methods: Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE(ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mgEPA + 200mg DHA, for 12 weeks) and 27 to the control group. The inflammatory medi ators and biochemical markers at T0 and T1 in omega-3 group were compared using Wilcoxon test. U-Mann–Whitney test was used to compare variations of measured variables[ V = pre-treatment (T0) − post-treatment (T1) concentrations] between groups. p < 0.05 was considered significant.Results: The median (interquartile range – IQR) of age was 37 (29–48) years old, of diseaseduration was 7 (4–13) years, and of SLEDAI-2K was 1 (0–2). The median (IQR) of variation in CRP levels between the two groups showed a decrease in omega-3 group while there was an increase in control group (p = 0.008). The serum concentrations of IL-6 and IL-10, leptin and adiponectin did not change after a 12 week treatment. Conclusions: Supplementation with omega-3 had no impact on serum concentrations of IL-6,IL-10, leptin and adiponectin in women with SLE and low disease activity. There was a significant decrease of CRP levels as well as evidence that omega-3 may impact total and LDL-cholesterol. |
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2023-08-08T23:40:13Z2023-08-08T23:40:13Z2016-10-22576526534https://doi.org/10.1016/j.rbre.2016.09.0142255-5021http://hdl.handle.net/1843/57633Background: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators.Objective: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus(SLE).Methods: Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE(ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mgEPA + 200mg DHA, for 12 weeks) and 27 to the control group. The inflammatory medi ators and biochemical markers at T0 and T1 in omega-3 group were compared using Wilcoxon test. U-Mann–Whitney test was used to compare variations of measured variables[ V = pre-treatment (T0) − post-treatment (T1) concentrations] between groups. p < 0.05 was considered significant.Results: The median (interquartile range – IQR) of age was 37 (29–48) years old, of diseaseduration was 7 (4–13) years, and of SLEDAI-2K was 1 (0–2). The median (IQR) of variation in CRP levels between the two groups showed a decrease in omega-3 group while there was an increase in control group (p = 0.008). The serum concentrations of IL-6 and IL-10, leptin and adiponectin did not change after a 12 week treatment. Conclusions: Supplementation with omega-3 had no impact on serum concentrations of IL-6,IL-10, leptin and adiponectin in women with SLE and low disease activity. There was a significant decrease of CRP levels as well as evidence that omega-3 may impact total and LDL-cholesterol.Introdução: Estudos têm mostrado que os ácidos graxos ômega-3 reduzem as concentraçõesséricas de eicosanoides, citocinas, quimiocinas, proteína C-reativa (PCR) e outros mediadores inflamatórios.Objetivo: Investigar os efeitos dos ácidos graxos ômega-3 sobre os níveis circulantes de mediadores inflamatórios e marcadores bioquímicos em mulheres com lúpus eritematoso sistêmico (LES).Métodos: Ensaio clínico randomizado (ensaio clínico: NCT02524795); foram randomizadas 49 mulheres com LES (ACR1982/1997): 22 para o grupo ômega-3 (dose diária de 1.080mg de EPA + 200mg de DHA durante 12 semanas) e 27 para o grupo controle. Os mediadores inflamatórios e marcadores bioquímicos em T0 e T1 no grupo ômega-3 foram comparados pelo teste de Wilcoxon. O teste U de Mann–Whitney foi usado para comparar variações das variáveis mensuradas [ V = concentrações pré-tratamento (T0) − concentrações pós-tratamento (T1)] entre os grupos. Um p < 0,05 foi considerado significativo. Resultados: A mediana (intervalo interquartil – IIQ) da idade foi de 37 anos (29 - 48), a duração da doença foi de sete anos (4 - 13) anos e o Systemic Lupus Disease Activity Index (SLEDAI-2K) foi de 1 (0 - 2). A mediana (IIQ) da variação nos níveis de PCR entre os dois grupos mostrou um decréscimo no grupo ômega-3, enquanto houve um aumento no grupo controle (p = 0,008).As concentrações séricas de IL-6 e IL-10, leptina e adiponectina não se alteraram após um tratamento de 12 semanas. Conclusões: A suplementação de ômega-3 não teve impacto sobre as concentrações séricas de IL-6, IL-10, leptina e adiponectina em mulheres com LES e baixa atividade da doença. Houveuma diminuição significativa nos níveis de PCR, bem como evidências de que o ômega-3 pode impactar sobre o colesterol total e LDL.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE APARELHO LOCOMOTORRevista Brasileira de Reumatologia (English Edition)Ácidos Graxos Ômega-3CitocinaProteína C-ReativaAdipocinasLúpus Eritematoso SistêmicoSystemic lupus erythematosusOmega 3CytokinesadipokinesC reactive proteinOmega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot studyÁcidos graxos ômega-3, estado inflamatório e marcadores bioquímicos de pacientes com lúpus eritematoso sistêmico: estudo pilotoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S2255502116300815?via%3DihubMariane Curado BorgesFabiana de Miranda Moura Dos SantosRosa Weiss TellesMarcus Vinícius Melo de AndradeMaria Isabel Toulson Davisson CorreiaCristina Costa Duarte Lannaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/57633/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALOmega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus pdfa.pdfOmega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus pdfa.pdfapplication/pdf336010https://repositorio.ufmg.br/bitstream/1843/57633/2/Omega-3%20fatty%20acids%2c%20inflammatory%20status%20and%20biochemical%20markers%20of%20patients%20with%20systemic%20lupus%20erythematosus%20pdfa.pdf194afe19fb49f35e15752e9252eb2901MD521843/576332023-08-09 13:41:33.399oai:repositorio.ufmg.br:1843/57633TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-08-09T16:41:33Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study |
dc.title.alternative.none.fl_str_mv |
Ácidos graxos ômega-3, estado inflamatório e marcadores bioquímicos de pacientes com lúpus eritematoso sistêmico: estudo piloto |
title |
Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study |
spellingShingle |
Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study Mariane Curado Borges Systemic lupus erythematosus Omega 3 Cytokines adipokines C reactive protein Ácidos Graxos Ômega-3 Citocina Proteína C-Reativa Adipocinas Lúpus Eritematoso Sistêmico |
title_short |
Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study |
title_full |
Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study |
title_fullStr |
Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study |
title_full_unstemmed |
Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study |
title_sort |
Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study |
author |
Mariane Curado Borges |
author_facet |
Mariane Curado Borges Fabiana de Miranda Moura Dos Santos Rosa Weiss Telles Marcus Vinícius Melo de Andrade Maria Isabel Toulson Davisson Correia Cristina Costa Duarte Lanna |
author_role |
author |
author2 |
Fabiana de Miranda Moura Dos Santos Rosa Weiss Telles Marcus Vinícius Melo de Andrade Maria Isabel Toulson Davisson Correia Cristina Costa Duarte Lanna |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Mariane Curado Borges Fabiana de Miranda Moura Dos Santos Rosa Weiss Telles Marcus Vinícius Melo de Andrade Maria Isabel Toulson Davisson Correia Cristina Costa Duarte Lanna |
dc.subject.por.fl_str_mv |
Systemic lupus erythematosus Omega 3 Cytokines adipokines C reactive protein |
topic |
Systemic lupus erythematosus Omega 3 Cytokines adipokines C reactive protein Ácidos Graxos Ômega-3 Citocina Proteína C-Reativa Adipocinas Lúpus Eritematoso Sistêmico |
dc.subject.other.pt_BR.fl_str_mv |
Ácidos Graxos Ômega-3 Citocina Proteína C-Reativa Adipocinas Lúpus Eritematoso Sistêmico |
description |
Background: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators.Objective: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus(SLE).Methods: Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE(ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mgEPA + 200mg DHA, for 12 weeks) and 27 to the control group. The inflammatory medi ators and biochemical markers at T0 and T1 in omega-3 group were compared using Wilcoxon test. U-Mann–Whitney test was used to compare variations of measured variables[ V = pre-treatment (T0) − post-treatment (T1) concentrations] between groups. p < 0.05 was considered significant.Results: The median (interquartile range – IQR) of age was 37 (29–48) years old, of diseaseduration was 7 (4–13) years, and of SLEDAI-2K was 1 (0–2). The median (IQR) of variation in CRP levels between the two groups showed a decrease in omega-3 group while there was an increase in control group (p = 0.008). The serum concentrations of IL-6 and IL-10, leptin and adiponectin did not change after a 12 week treatment. Conclusions: Supplementation with omega-3 had no impact on serum concentrations of IL-6,IL-10, leptin and adiponectin in women with SLE and low disease activity. There was a significant decrease of CRP levels as well as evidence that omega-3 may impact total and LDL-cholesterol. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-10-22 |
dc.date.accessioned.fl_str_mv |
2023-08-08T23:40:13Z |
dc.date.available.fl_str_mv |
2023-08-08T23:40:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/57633 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.rbre.2016.09.014 |
dc.identifier.issn.pt_BR.fl_str_mv |
2255-5021 |
url |
https://doi.org/10.1016/j.rbre.2016.09.014 http://hdl.handle.net/1843/57633 |
identifier_str_mv |
2255-5021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Revista Brasileira de Reumatologia (English Edition) |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE APARELHO LOCOMOTOR |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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