Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Monografias da UFMT |
Texto Completo: | http://bdm.ufmt.br/handle/1/1897 |
Resumo: | Introduction: Medicinal plants have been widely used by society in the treatment and prevention of various diseases, however without knowledge of the benefits or possible harm, and the population persists in the belief that plant products do not cause damage to the organism. Strychnos pseudoquina, is widely used in popular medicine and is used for various therapeutic purposes, however there are still no studies in the literature on its effects during pregnancy. Objective: To evaluate during the pregnancy of rats, repercussions of the aqueous extract of S. pseudoquina in relation to maternal toxicity and reproductive performance. Materials and methods: Wistar rats (male and female) were used, which after mating and pregnancy were confirmed, were randomly assigned to four experimental groups (n minimum = 11 rats / group): Control - rats treated with water; Treaty 75, Treaty 150 and Treaty 300 - Treated with plant extract in the doses of 75 mg / kg, 150 mg / kg and 300 mg / kg, respectively. The treatment with the aqueous extract was orally (gavage), during the entire pregnancy. On the 21st day of pregnancy, the rats were anesthetized and laparotomy was performed. Then the heart, liver, spleen and kidneys were removed and weighed. After removal of the uterus, implantation points, resorption (embryonic death) and numbers of live and dead fetuses were observed and counted. The ovaries were removed for observation and counting of corpus luteum. Results: The treatment with S. pseudoquina at a dose of 75mg / Kg caused an increase in water intake and food consumption. The Treated 150 group showed an increase in water and food intake, in the percentage of pre-implantation loss and a decrease in the number of corpus luteum. The treated 300 group showed a decrease in water intake, food consumption, relative liver mass, maternal weight gain, weight of the pregnant uterus, number of live and implanted fetuses. Increase in relative kidney mass, resorption, percentage of pre-implantation and postimplantation loss. Conclusion: The administration of aqueous extract of S. pseudoquine, at a dose of 300 mg / kg, in pregnant Wistar rats induces maternal toxicity, in addition to increasing embryonic losses. Therefore, treatment during pregnancy with this plant can be harmful, depending on the dose used. |
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Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratasCNPQ::OUTROS::BIOMEDICINAQuina do cerradoplantas medicinaisperformance reprodutivaprenhezQuina do cerradomedicinal plantsreproductive performancepregnancyIntroduction: Medicinal plants have been widely used by society in the treatment and prevention of various diseases, however without knowledge of the benefits or possible harm, and the population persists in the belief that plant products do not cause damage to the organism. Strychnos pseudoquina, is widely used in popular medicine and is used for various therapeutic purposes, however there are still no studies in the literature on its effects during pregnancy. Objective: To evaluate during the pregnancy of rats, repercussions of the aqueous extract of S. pseudoquina in relation to maternal toxicity and reproductive performance. Materials and methods: Wistar rats (male and female) were used, which after mating and pregnancy were confirmed, were randomly assigned to four experimental groups (n minimum = 11 rats / group): Control - rats treated with water; Treaty 75, Treaty 150 and Treaty 300 - Treated with plant extract in the doses of 75 mg / kg, 150 mg / kg and 300 mg / kg, respectively. The treatment with the aqueous extract was orally (gavage), during the entire pregnancy. On the 21st day of pregnancy, the rats were anesthetized and laparotomy was performed. Then the heart, liver, spleen and kidneys were removed and weighed. After removal of the uterus, implantation points, resorption (embryonic death) and numbers of live and dead fetuses were observed and counted. The ovaries were removed for observation and counting of corpus luteum. Results: The treatment with S. pseudoquina at a dose of 75mg / Kg caused an increase in water intake and food consumption. The Treated 150 group showed an increase in water and food intake, in the percentage of pre-implantation loss and a decrease in the number of corpus luteum. The treated 300 group showed a decrease in water intake, food consumption, relative liver mass, maternal weight gain, weight of the pregnant uterus, number of live and implanted fetuses. Increase in relative kidney mass, resorption, percentage of pre-implantation and postimplantation loss. Conclusion: The administration of aqueous extract of S. pseudoquine, at a dose of 300 mg / kg, in pregnant Wistar rats induces maternal toxicity, in addition to increasing embryonic losses. Therefore, treatment during pregnancy with this plant can be harmful, depending on the dose used.Introdução: As plantas medicinais vêm sendo bastante utilizada pela sociedade no tratamento e prevenção de variadas enfermidade, contudo sem o conhecimento dos benefícios ou eventuais malefícios, e a população persiste na crença de que produtos vegetais não causam danos ao organismo. A Strychnos pseudoquina, é amplamente empregada na medicina popular sendo utilizada para variados fins terapêuticos, no entanto ainda não há na literatura estudos sobre seus efeitos durante a gestação. Objetivo: Avaliar durante a prenhez de ratas, repercussões do extrato aquoso de S. pseudoquina em relação à toxicidade materna e performance reprodutiva. Materiais e métodos: Foram utilizadas ratos Wistar (machos e fêmeas), que após acasaladas e confirmada a prenhez, foram distribuídas aleatoriamente em quatro grupos experimentais (n mínimo = 11 ratas/grupo): Controle – ratas tratadas com água; Tratado 75, Tratado 150 e Tratado 300 - Tratadas com extrato da planta nas doses de 75 mg/kg, 150 mg/kg e 300 mg/kg, respectivamente. O tratamento com o extrato aquoso foi por via oral (gavagem), durante toda a prenhez. No 21º dia de prenhez, as ratas foram anestesiadas e realizada laparotomia. Em seguida, coração, fígado, baço e rins foram retirados e pesados. Após retirada do útero, foram observados e contados os pontos de implantação, reabsorção (morte embrionária) e números de fetos vivos e mortos. Os ovários foram retirados para observação e contagem de corpos lúteos. Resultados: O tratamento com S. pseudoquina na dose de 75mg/Kg causou aumento de ingestão hídrica e consumo alimentar. O grupo Tratado 150 apresentou aumento na ingestão hídrica e alimentar, na porcentagem de perda pré-implantação e diminuição do número de corpos lúteos. O grupo Tratado 300 houve diminuição na ingestão hídrica, consumo alimentar, da massa relativa do fígado, ganho de peso materno, peso do útero gravídico, número de fetos vivos e de implantação. Aumento da massa relativa dos rins, reabsorções, porcentagem de perda pré-implantação e pós-implantação. Conclusão: A administração do extrato aquoso de S. pseudoquina, na dose de 300 mg/Kg, em ratas Wistar prenhes induz toxicidade materna, além de aumentar as perdas embrionárias. Portanto, o tratamUniversidade Federal de Mato GrossoBrasilInstituto de Ciências Biológicas e da Saúde (ICBS) – AraguaiaUFMT CUA - AraguaiaBiomedicina - CUAVolpato, Gustavo Tadeuhttp://lattes.cnpq.br/8276825973471698Souza, Maysa Rocha dehttp://lattes.cnpq.br/9695924931401956Volpato, Gustavo Tadeuhttp://lattes.cnpq.br/8276825973471698Souza, Rafaianne Queiroz de Moraeshttp://lattes.cnpq.br/7377024454258259Souza, Maysa Rocha dehttp://lattes.cnpq.br/9695924931401956Brito, Evelyn Caroline Barbosa2021-07-04T20:40:00Z2020-03-062021-07-04T20:40:00Z2020-02-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/datasetBRITO, Evelyn Caroline Barbosa. Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas. 2020. 35 f. TCC (Graduação em Biomedicina) - Universidade Federal do Mato Grosso, Campus Universitário do Araguaia, Instituto de Ciências Biológicas e da Saúde, Barra do Garças, 2020.http://bdm.ufmt.br/handle/1/1897porinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Monografias da UFMTinstname:Universidade Federal de Mato Grosso (UFMT)instacron:UFMT2021-07-20T07:00:18Zoai:localhost:1/1897Biblioteca Digital de Monografiahttps://bdm.ufmt.br/PUBhttp://200.129.241.122/oai/requestopendoar:2021-07-20T07:00:18falseBiblioteca Digital de Monografiahttps://bdm.ufmt.br/PUBhttp://200.129.241.122/oai/requestbibliotecacentral@ufmt.br||opendoar:2021-07-20T07:00:18Biblioteca Digital de Monografias da UFMT - Universidade Federal de Mato Grosso (UFMT)false |
dc.title.none.fl_str_mv |
Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas |
title |
Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas |
spellingShingle |
Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas Brito, Evelyn Caroline Barbosa CNPQ::OUTROS::BIOMEDICINA Quina do cerrado plantas medicinais performance reprodutiva prenhez Quina do cerrado medicinal plants reproductive performance pregnancy |
title_short |
Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas |
title_full |
Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas |
title_fullStr |
Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas |
title_full_unstemmed |
Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas |
title_sort |
Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas |
author |
Brito, Evelyn Caroline Barbosa |
author_facet |
Brito, Evelyn Caroline Barbosa |
author_role |
author |
dc.contributor.none.fl_str_mv |
Volpato, Gustavo Tadeu http://lattes.cnpq.br/8276825973471698 Souza, Maysa Rocha de http://lattes.cnpq.br/9695924931401956 Volpato, Gustavo Tadeu http://lattes.cnpq.br/8276825973471698 Souza, Rafaianne Queiroz de Moraes http://lattes.cnpq.br/7377024454258259 Souza, Maysa Rocha de http://lattes.cnpq.br/9695924931401956 |
dc.contributor.author.fl_str_mv |
Brito, Evelyn Caroline Barbosa |
dc.subject.por.fl_str_mv |
CNPQ::OUTROS::BIOMEDICINA Quina do cerrado plantas medicinais performance reprodutiva prenhez Quina do cerrado medicinal plants reproductive performance pregnancy |
topic |
CNPQ::OUTROS::BIOMEDICINA Quina do cerrado plantas medicinais performance reprodutiva prenhez Quina do cerrado medicinal plants reproductive performance pregnancy |
description |
Introduction: Medicinal plants have been widely used by society in the treatment and prevention of various diseases, however without knowledge of the benefits or possible harm, and the population persists in the belief that plant products do not cause damage to the organism. Strychnos pseudoquina, is widely used in popular medicine and is used for various therapeutic purposes, however there are still no studies in the literature on its effects during pregnancy. Objective: To evaluate during the pregnancy of rats, repercussions of the aqueous extract of S. pseudoquina in relation to maternal toxicity and reproductive performance. Materials and methods: Wistar rats (male and female) were used, which after mating and pregnancy were confirmed, were randomly assigned to four experimental groups (n minimum = 11 rats / group): Control - rats treated with water; Treaty 75, Treaty 150 and Treaty 300 - Treated with plant extract in the doses of 75 mg / kg, 150 mg / kg and 300 mg / kg, respectively. The treatment with the aqueous extract was orally (gavage), during the entire pregnancy. On the 21st day of pregnancy, the rats were anesthetized and laparotomy was performed. Then the heart, liver, spleen and kidneys were removed and weighed. After removal of the uterus, implantation points, resorption (embryonic death) and numbers of live and dead fetuses were observed and counted. The ovaries were removed for observation and counting of corpus luteum. Results: The treatment with S. pseudoquina at a dose of 75mg / Kg caused an increase in water intake and food consumption. The Treated 150 group showed an increase in water and food intake, in the percentage of pre-implantation loss and a decrease in the number of corpus luteum. The treated 300 group showed a decrease in water intake, food consumption, relative liver mass, maternal weight gain, weight of the pregnant uterus, number of live and implanted fetuses. Increase in relative kidney mass, resorption, percentage of pre-implantation and postimplantation loss. Conclusion: The administration of aqueous extract of S. pseudoquine, at a dose of 300 mg / kg, in pregnant Wistar rats induces maternal toxicity, in addition to increasing embryonic losses. Therefore, treatment during pregnancy with this plant can be harmful, depending on the dose used. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-06 2020-02-18 2021-07-04T20:40:00Z 2021-07-04T20:40:00Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/bachelorThesis info:eu-repo/semantics/dataset |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
BRITO, Evelyn Caroline Barbosa. Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas. 2020. 35 f. TCC (Graduação em Biomedicina) - Universidade Federal do Mato Grosso, Campus Universitário do Araguaia, Instituto de Ciências Biológicas e da Saúde, Barra do Garças, 2020. http://bdm.ufmt.br/handle/1/1897 |
identifier_str_mv |
BRITO, Evelyn Caroline Barbosa. Repercussões maternas do tratamento com strychnos pseudoquina durante a prenhez de ratas. 2020. 35 f. TCC (Graduação em Biomedicina) - Universidade Federal do Mato Grosso, Campus Universitário do Araguaia, Instituto de Ciências Biológicas e da Saúde, Barra do Garças, 2020. |
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http://bdm.ufmt.br/handle/1/1897 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Mato Grosso Brasil Instituto de Ciências Biológicas e da Saúde (ICBS) – Araguaia UFMT CUA - Araguaia Biomedicina - CUA |
publisher.none.fl_str_mv |
Universidade Federal de Mato Grosso Brasil Instituto de Ciências Biológicas e da Saúde (ICBS) – Araguaia UFMT CUA - Araguaia Biomedicina - CUA |
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reponame:Biblioteca Digital de Monografias da UFMT instname:Universidade Federal de Mato Grosso (UFMT) instacron:UFMT |
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Universidade Federal de Mato Grosso (UFMT) |
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UFMT |
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Biblioteca Digital de Monografias da UFMT |
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Biblioteca Digital de Monografias da UFMT - Universidade Federal de Mato Grosso (UFMT) |
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