AVALIAÇÃO DA CITO-GENOTOXICIDADE E DA ATIVIDADE FRENTE A Haemonchus contortus DE NANOEMULSÕES CONTENDO ÓLEO DE EUCALIPTO

• Autor(a) principal: GODOI, Samantha Nunes de
• Data de Publicação: 2018
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional Universidade Franciscana
• Texto Completo: http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/730
• topic: nanociências; parasita; toxicidade.; nanosciences; parasite; toxicity.; Nanociências

Currently, the state of Rio Grande do Sul is the main producer of sheep in Brazil, however, the parasitosis caused by gastrointestinal nematodes makes up the main problem of sheep herds. Correct management of this pathology is decisive, otherwise sheep farming may become economically impractical due to decreased productivity and animal mortality. Haemonchus contortus is a helminth that has a prevalence of 88% in sheep and can lead to death. Anti-helminths do not guarantee immediate and lasting efficacy and this is due to the high occurrence of resistance to anthelmintics, which may be associated with the frequent treatment of animals with these substances. Recognizing the problem of anthelmintic resistance arises the need to analyze the capacity of new substances, it becomes interesting and necessary the study of products derived from plants and their potential actions, as an active principle of possible antiparasitic agents, among them the essencial oils. Essential oils have different pharmacological properties, however, their therapeutic efficacy may be limited due to possible instability against some conditions, so an alternative to increase stability and ensure the efficacy of this compound would be nanoemulsification. From these factors the objective of this study is to evaluate the cyto-genotoxic activity and activity against Haemonchus contortus of nanoemulsions containing Eucalyptus globulus oil. As results, we were successful in the preparation, optimization of the preparation method, characterization of nanoemulsions. The formulation used in this work did not present toxic behavior against ovine peripheral blood mononuclear cells and the nanoemulsion containing Eucalyptus globulus oil showed an important anthelmintic potential against eggs of Haemonchus contortus larvae. Thus, the relevance of this study, whose main characteristic is the application of several areas of knowledge and which brings a possible and potential alternative in the control of haemonchose in sheep rearing