The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/10967 |
Resumo: | BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host. |
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The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.InflammationHeart diseaseChemokinesBACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host.2019-04-08T18:02:55Z2019-04-08T18:02:55Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHORTA, A. L. et al. The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, v. 113, n. 11, p. 1-8, 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762018001100301&lng=pt&nrm=iso&tlng=pt>. Acesso em: 22 fev. 2019.00740276http://www.repositorio.ufop.br/handle/123456789/10967Todo o conteúdo do periódico Memórias do Instituto Oswaldo Cruz, exceto onde identificado, está licenciado sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Memórias do Instituto Oswaldo Cruz <http://www.scielo.br/scielo.php/script_sci_serial/pid_0074-0276/lng_pt/nrm_iso>. Acesso em: 03 jan. 2017.info:eu-repo/semantics/openAccessHorta, Aline LucianoFigueiredo, Vivian PaulinoLeite, Ana Luísa JunqueiraCosta, Guilherme de PaulaMenezes, Ana Paula de JesusRamos, Camila de OliveiraPedrosa, Tamiles Caroline FernandesBezerra, Frank SilvaVieira, Paula Melo de AbreuSilva, André Talvani Pedrosa daengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-04-08T18:02:55Zoai:repositorio.ufop.br:123456789/10967Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-04-08T18:02:55Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. |
title |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. |
spellingShingle |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Horta, Aline Luciano Inflammation Heart disease Chemokines |
title_short |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. |
title_full |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. |
title_fullStr |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. |
title_full_unstemmed |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. |
title_sort |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. |
author |
Horta, Aline Luciano |
author_facet |
Horta, Aline Luciano Figueiredo, Vivian Paulino Leite, Ana Luísa Junqueira Costa, Guilherme de Paula Menezes, Ana Paula de Jesus Ramos, Camila de Oliveira Pedrosa, Tamiles Caroline Fernandes Bezerra, Frank Silva Vieira, Paula Melo de Abreu Silva, André Talvani Pedrosa da |
author_role |
author |
author2 |
Figueiredo, Vivian Paulino Leite, Ana Luísa Junqueira Costa, Guilherme de Paula Menezes, Ana Paula de Jesus Ramos, Camila de Oliveira Pedrosa, Tamiles Caroline Fernandes Bezerra, Frank Silva Vieira, Paula Melo de Abreu Silva, André Talvani Pedrosa da |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Horta, Aline Luciano Figueiredo, Vivian Paulino Leite, Ana Luísa Junqueira Costa, Guilherme de Paula Menezes, Ana Paula de Jesus Ramos, Camila de Oliveira Pedrosa, Tamiles Caroline Fernandes Bezerra, Frank Silva Vieira, Paula Melo de Abreu Silva, André Talvani Pedrosa da |
dc.subject.por.fl_str_mv |
Inflammation Heart disease Chemokines |
topic |
Inflammation Heart disease Chemokines |
description |
BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2019-04-08T18:02:55Z 2019-04-08T18:02:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
HORTA, A. L. et al. The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, v. 113, n. 11, p. 1-8, 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762018001100301&lng=pt&nrm=iso&tlng=pt>. Acesso em: 22 fev. 2019. 00740276 http://www.repositorio.ufop.br/handle/123456789/10967 |
identifier_str_mv |
HORTA, A. L. et al. The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, v. 113, n. 11, p. 1-8, 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762018001100301&lng=pt&nrm=iso&tlng=pt>. Acesso em: 22 fev. 2019. 00740276 |
url |
http://www.repositorio.ufop.br/handle/123456789/10967 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
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Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
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repositorio@ufop.edu.br |
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