The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.

Detalhes bibliográficos
Autor(a) principal: Horta, Aline Luciano
Data de Publicação: 2018
Outros Autores: Figueiredo, Vivian Paulino, Leite, Ana Luísa Junqueira, Costa, Guilherme de Paula, Menezes, Ana Paula de Jesus, Ramos, Camila de Oliveira, Pedrosa, Tamiles Caroline Fernandes, Bezerra, Frank Silva, Vieira, Paula Melo de Abreu, Silva, André Talvani Pedrosa da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/10967
Resumo: BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host.
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spelling The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.InflammationHeart diseaseChemokinesBACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host.2019-04-08T18:02:55Z2019-04-08T18:02:55Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHORTA, A. L. et al. The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, v. 113, n. 11, p. 1-8, 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762018001100301&lng=pt&nrm=iso&tlng=pt>. Acesso em: 22 fev. 2019.00740276http://www.repositorio.ufop.br/handle/123456789/10967Todo o conteúdo do periódico Memórias do Instituto Oswaldo Cruz, exceto onde identificado, está licenciado sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Memórias do Instituto Oswaldo Cruz <http://www.scielo.br/scielo.php/script_sci_serial/pid_0074-0276/lng_pt/nrm_iso>. Acesso em: 03 jan. 2017.info:eu-repo/semantics/openAccessHorta, Aline LucianoFigueiredo, Vivian PaulinoLeite, Ana Luísa JunqueiraCosta, Guilherme de PaulaMenezes, Ana Paula de JesusRamos, Camila de OliveiraPedrosa, Tamiles Caroline FernandesBezerra, Frank SilvaVieira, Paula Melo de AbreuSilva, André Talvani Pedrosa daengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-04-08T18:02:55Zoai:repositorio.ufop.br:123456789/10967Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-04-08T18:02:55Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
title The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
spellingShingle The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
Horta, Aline Luciano
Inflammation
Heart disease
Chemokines
title_short The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
title_full The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
title_fullStr The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
title_full_unstemmed The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
title_sort The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
author Horta, Aline Luciano
author_facet Horta, Aline Luciano
Figueiredo, Vivian Paulino
Leite, Ana Luísa Junqueira
Costa, Guilherme de Paula
Menezes, Ana Paula de Jesus
Ramos, Camila de Oliveira
Pedrosa, Tamiles Caroline Fernandes
Bezerra, Frank Silva
Vieira, Paula Melo de Abreu
Silva, André Talvani Pedrosa da
author_role author
author2 Figueiredo, Vivian Paulino
Leite, Ana Luísa Junqueira
Costa, Guilherme de Paula
Menezes, Ana Paula de Jesus
Ramos, Camila de Oliveira
Pedrosa, Tamiles Caroline Fernandes
Bezerra, Frank Silva
Vieira, Paula Melo de Abreu
Silva, André Talvani Pedrosa da
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Horta, Aline Luciano
Figueiredo, Vivian Paulino
Leite, Ana Luísa Junqueira
Costa, Guilherme de Paula
Menezes, Ana Paula de Jesus
Ramos, Camila de Oliveira
Pedrosa, Tamiles Caroline Fernandes
Bezerra, Frank Silva
Vieira, Paula Melo de Abreu
Silva, André Talvani Pedrosa da
dc.subject.por.fl_str_mv Inflammation
Heart disease
Chemokines
topic Inflammation
Heart disease
Chemokines
description BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019-04-08T18:02:55Z
2019-04-08T18:02:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv HORTA, A. L. et al. The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, v. 113, n. 11, p. 1-8, 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762018001100301&lng=pt&nrm=iso&tlng=pt>. Acesso em: 22 fev. 2019.
00740276
http://www.repositorio.ufop.br/handle/123456789/10967
identifier_str_mv HORTA, A. L. et al. The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, v. 113, n. 11, p. 1-8, 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762018001100301&lng=pt&nrm=iso&tlng=pt>. Acesso em: 22 fev. 2019.
00740276
url http://www.repositorio.ufop.br/handle/123456789/10967
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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