ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.

Detalhes bibliográficos
Autor(a) principal: Lucas Filho, Milton Dayrell
Data de Publicação: 2010
Outros Autores: Silva, Grazielle Caroline da, Côrtes, Steyner de França, Guia, Thiago Rennó dos Mares, Ferraz, Vany Perpetua, Serra, Carla Penido, Braga, Fernão Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/1214
Resumo: Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration.
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spelling ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.AstilbinErythroxylum gonocladumIn vitro angiotensin converting enzyme inhibitory activityErythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration.2012-07-30T14:17:18Z2012-07-30T14:17:18Z2010info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfLUCAS FILHO, M. D. et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine, v. 17, n. 5, p. 383-387, abr. 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0944711309002372>. Acesso em: 30 jul. 2012.09447113http://www.repositorio.ufop.br/handle/123456789/1214O periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3347180657438.info:eu-repo/semantics/openAccessLucas Filho, Milton DayrellSilva, Grazielle Caroline daCôrtes, Steyner de FrançaGuia, Thiago Rennó dos MaresFerraz, Vany PerpetuaSerra, Carla PenidoBraga, Fernão Castroengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-02-28T15:09:56Zoai:repositorio.ufop.br:123456789/1214Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-02-28T15:09:56Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
title ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
spellingShingle ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
Lucas Filho, Milton Dayrell
Astilbin
Erythroxylum gonocladum
In vitro angiotensin converting enzyme inhibitory activity
title_short ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
title_full ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
title_fullStr ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
title_full_unstemmed ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
title_sort ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
author Lucas Filho, Milton Dayrell
author_facet Lucas Filho, Milton Dayrell
Silva, Grazielle Caroline da
Côrtes, Steyner de França
Guia, Thiago Rennó dos Mares
Ferraz, Vany Perpetua
Serra, Carla Penido
Braga, Fernão Castro
author_role author
author2 Silva, Grazielle Caroline da
Côrtes, Steyner de França
Guia, Thiago Rennó dos Mares
Ferraz, Vany Perpetua
Serra, Carla Penido
Braga, Fernão Castro
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lucas Filho, Milton Dayrell
Silva, Grazielle Caroline da
Côrtes, Steyner de França
Guia, Thiago Rennó dos Mares
Ferraz, Vany Perpetua
Serra, Carla Penido
Braga, Fernão Castro
dc.subject.por.fl_str_mv Astilbin
Erythroxylum gonocladum
In vitro angiotensin converting enzyme inhibitory activity
topic Astilbin
Erythroxylum gonocladum
In vitro angiotensin converting enzyme inhibitory activity
description Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration.
publishDate 2010
dc.date.none.fl_str_mv 2010
2012-07-30T14:17:18Z
2012-07-30T14:17:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv LUCAS FILHO, M. D. et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine, v. 17, n. 5, p. 383-387, abr. 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0944711309002372>. Acesso em: 30 jul. 2012.
09447113
http://www.repositorio.ufop.br/handle/123456789/1214
identifier_str_mv LUCAS FILHO, M. D. et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine, v. 17, n. 5, p. 383-387, abr. 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0944711309002372>. Acesso em: 30 jul. 2012.
09447113
url http://www.repositorio.ufop.br/handle/123456789/1214
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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