Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice.
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/7310 http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02370.x/abstract https://doi.org/10.1111/j.1365-3083.2010.02370.x |
Resumo: | Ageing is associated with several alterations in the immune system. Our aim in this study was to compare the development of immunity to Schistosoma mansoni infection in young versus aged C57Bl ⁄ 6 mice using the liver as the main organ to evaluate pathological alterations and immune responses. In the acute phase, young mice had large liver granulomas with fibrosis and inflammatory cells. Chronic phase in young animals was associated with immunomodulation of granulomas that became reduced in size and cellular infiltrate. On the other hand, aged animals presented granulomas of smaller sizes already in the acute phase. Chronic infection in these mice was followed by no alteration in any of the inflammatory parameters in the liver. In concert with this finding, there was an increase in activated CD4+ T, CD19+ B and NK liver cells in young mice after infection whereas old mice had already higher frequencies of activated B, NK and CD4+ T liver cells and infection does not change these frequencies. After infection, liver production of inflammatory and regulatory cytokines such as IFN-c, IL-4 and IL-10 increased in young but not in old mice that had high levels of IL-4 and IL-10 regardless of their infection status. Our data suggest that the unspecific activation status of the immune system in aged mice impairs inflammatory as well as regulatory immune responses to S. mansoni infection in the liver, where major pathological alterations and immunity are at stage. This poor immune reactivity may have a beneficial impact on disease development. |
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Faria, Elaine Speziali deAranha, Claudio Henrique MagalhãesCarvalho, Andréa Teixeira deSantiago, Andrezza FernandaOliveira, Rafael Pires deRezende, Michelle Carvalho deCarneiro, Claudia MartinsCorrêa, Deborah Aparecida NegrãoCoelho, Paulo Marcos ZechFaria, Ana Maria Caetano de2017-02-23T17:18:25Z2017-02-23T17:18:25Z2010FARIA, E. S. et al. Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. Scandinavian Journal of Immunology, v. 71, p.240-248, 2010. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02370.x/abstract>. Acesso em: 10 jan. 2017. 1365-3083http://www.repositorio.ufop.br/handle/123456789/7310http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02370.x/abstracthttps://doi.org/10.1111/j.1365-3083.2010.02370.xAgeing is associated with several alterations in the immune system. Our aim in this study was to compare the development of immunity to Schistosoma mansoni infection in young versus aged C57Bl ⁄ 6 mice using the liver as the main organ to evaluate pathological alterations and immune responses. In the acute phase, young mice had large liver granulomas with fibrosis and inflammatory cells. Chronic phase in young animals was associated with immunomodulation of granulomas that became reduced in size and cellular infiltrate. On the other hand, aged animals presented granulomas of smaller sizes already in the acute phase. Chronic infection in these mice was followed by no alteration in any of the inflammatory parameters in the liver. In concert with this finding, there was an increase in activated CD4+ T, CD19+ B and NK liver cells in young mice after infection whereas old mice had already higher frequencies of activated B, NK and CD4+ T liver cells and infection does not change these frequencies. After infection, liver production of inflammatory and regulatory cytokines such as IFN-c, IL-4 and IL-10 increased in young but not in old mice that had high levels of IL-4 and IL-10 regardless of their infection status. Our data suggest that the unspecific activation status of the immune system in aged mice impairs inflammatory as well as regulatory immune responses to S. mansoni infection in the liver, where major pathological alterations and immunity are at stage. This poor immune reactivity may have a beneficial impact on disease development.Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/7310/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_AgeingDownModulates.pdfARTIGO_AgeingDownModulates.pdfapplication/pdf722564http://www.repositorio.ufop.br/bitstream/123456789/7310/1/ARTIGO_AgeingDownModulates.pdfd82523847dbb28a7257b47c40752e77cMD51123456789/73102019-10-25 11:53:47.303oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-10-25T15:53:47Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. |
title |
Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. |
spellingShingle |
Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. Faria, Elaine Speziali de |
title_short |
Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. |
title_full |
Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. |
title_fullStr |
Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. |
title_full_unstemmed |
Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. |
title_sort |
Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. |
author |
Faria, Elaine Speziali de |
author_facet |
Faria, Elaine Speziali de Aranha, Claudio Henrique Magalhães Carvalho, Andréa Teixeira de Santiago, Andrezza Fernanda Oliveira, Rafael Pires de Rezende, Michelle Carvalho de Carneiro, Claudia Martins Corrêa, Deborah Aparecida Negrão Coelho, Paulo Marcos Zech Faria, Ana Maria Caetano de |
author_role |
author |
author2 |
Aranha, Claudio Henrique Magalhães Carvalho, Andréa Teixeira de Santiago, Andrezza Fernanda Oliveira, Rafael Pires de Rezende, Michelle Carvalho de Carneiro, Claudia Martins Corrêa, Deborah Aparecida Negrão Coelho, Paulo Marcos Zech Faria, Ana Maria Caetano de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Faria, Elaine Speziali de Aranha, Claudio Henrique Magalhães Carvalho, Andréa Teixeira de Santiago, Andrezza Fernanda Oliveira, Rafael Pires de Rezende, Michelle Carvalho de Carneiro, Claudia Martins Corrêa, Deborah Aparecida Negrão Coelho, Paulo Marcos Zech Faria, Ana Maria Caetano de |
description |
Ageing is associated with several alterations in the immune system. Our aim in this study was to compare the development of immunity to Schistosoma mansoni infection in young versus aged C57Bl ⁄ 6 mice using the liver as the main organ to evaluate pathological alterations and immune responses. In the acute phase, young mice had large liver granulomas with fibrosis and inflammatory cells. Chronic phase in young animals was associated with immunomodulation of granulomas that became reduced in size and cellular infiltrate. On the other hand, aged animals presented granulomas of smaller sizes already in the acute phase. Chronic infection in these mice was followed by no alteration in any of the inflammatory parameters in the liver. In concert with this finding, there was an increase in activated CD4+ T, CD19+ B and NK liver cells in young mice after infection whereas old mice had already higher frequencies of activated B, NK and CD4+ T liver cells and infection does not change these frequencies. After infection, liver production of inflammatory and regulatory cytokines such as IFN-c, IL-4 and IL-10 increased in young but not in old mice that had high levels of IL-4 and IL-10 regardless of their infection status. Our data suggest that the unspecific activation status of the immune system in aged mice impairs inflammatory as well as regulatory immune responses to S. mansoni infection in the liver, where major pathological alterations and immunity are at stage. This poor immune reactivity may have a beneficial impact on disease development. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2017-02-23T17:18:25Z |
dc.date.available.fl_str_mv |
2017-02-23T17:18:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FARIA, E. S. et al. Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. Scandinavian Journal of Immunology, v. 71, p.240-248, 2010. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02370.x/abstract>. Acesso em: 10 jan. 2017. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/7310 |
dc.identifier.issn.none.fl_str_mv |
1365-3083 |
dc.identifier.uri2.pt_BR.fl_str_mv |
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02370.x/abstract |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1111/j.1365-3083.2010.02370.x |
identifier_str_mv |
FARIA, E. S. et al. Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. Scandinavian Journal of Immunology, v. 71, p.240-248, 2010. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02370.x/abstract>. Acesso em: 10 jan. 2017. 1365-3083 |
url |
http://www.repositorio.ufop.br/handle/123456789/7310 http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02370.x/abstract https://doi.org/10.1111/j.1365-3083.2010.02370.x |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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