Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/3825 http://dx.doi.org/10.1590/1414-431X20132609 |
Resumo: | Obesity is a multifactorial disorder often associated with many important diseases such as diabetes, hypertension and other metabolic syndrome conditions. Argyrophil cells represent almost the total population of endocrine cells of the human gastric mucosa and some reports have described changes of specific types of these cells in patients with obesity and metabolic syndrome. The present study was designed to evaluate the global population of argyrophil cells of the gastric mucosa of morbidly obese and dyspeptic non-obese patients. Gastric biopsies of antropyloric and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI .40) and 50 non-obese patients (17 dyspeptic overweight and 33 lean individuals) and processed for histology and Grimelius staining for argyrophil cell demonstration. Argyrophil cell density in the oxyntic mucosa of morbidly obese patients was higher in female (238.68 ± 83.71 cells/mm2) than in male patients (179.31 ± 85.96 cells/mm2) and also higher in female (214.20 ± 50.38 cells/mm2) than in male (141.90 ± 61.22 cells/mm2) morbidly obese patients with metabolic syndrome (P = 0.01 and P = 0.02, respectively). In antropyloric mucosa, the main difference in argyrophil cell density was observed between female morbidly obese patients with (167.00 ± 69.30 cells/mm2) and without (234.00 ± 69.54 cells/mm2) metabolic syndrome (P = 0.001). In conclusion, the present results show that the number of gastric argyrophil cells could be under gender influence in patients with morbid obesity. In addition, gastric argyrophil cells seem to behave differently among female morbidly obese patients with and without metabolic syndrome. |
id |
UFOP_d18b42e6a01011acf3ea2df43e15b47f |
---|---|
oai_identifier_str |
oai:repositorio.ufop.br:123456789/3825 |
network_acronym_str |
UFOP |
network_name_str |
Repositório Institucional da UFOP |
repository_id_str |
3233 |
spelling |
Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.Argyrophil cellsEndocrine cellsObesityGastric mucosaMetabolic syndromeObesity is a multifactorial disorder often associated with many important diseases such as diabetes, hypertension and other metabolic syndrome conditions. Argyrophil cells represent almost the total population of endocrine cells of the human gastric mucosa and some reports have described changes of specific types of these cells in patients with obesity and metabolic syndrome. The present study was designed to evaluate the global population of argyrophil cells of the gastric mucosa of morbidly obese and dyspeptic non-obese patients. Gastric biopsies of antropyloric and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI .40) and 50 non-obese patients (17 dyspeptic overweight and 33 lean individuals) and processed for histology and Grimelius staining for argyrophil cell demonstration. Argyrophil cell density in the oxyntic mucosa of morbidly obese patients was higher in female (238.68 ± 83.71 cells/mm2) than in male patients (179.31 ± 85.96 cells/mm2) and also higher in female (214.20 ± 50.38 cells/mm2) than in male (141.90 ± 61.22 cells/mm2) morbidly obese patients with metabolic syndrome (P = 0.01 and P = 0.02, respectively). In antropyloric mucosa, the main difference in argyrophil cell density was observed between female morbidly obese patients with (167.00 ± 69.30 cells/mm2) and without (234.00 ± 69.54 cells/mm2) metabolic syndrome (P = 0.001). In conclusion, the present results show that the number of gastric argyrophil cells could be under gender influence in patients with morbid obesity. In addition, gastric argyrophil cells seem to behave differently among female morbidly obese patients with and without metabolic syndrome.2014-11-12T19:20:25Z2014-11-12T19:20:25Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMAKSUD, F. A. N; KAKEHASI, A. M.; BARBOSA, A. J. A. Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. Brazilian Journal of Medical and Biological Research, v. 46, p. 339-342, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400339>. Acesso em: 01 set. 2014.1414-431Xhttp://www.repositorio.ufop.br/handle/123456789/3825http://dx.doi.org/10.1590/1414-431X20132609Todo o conteúdo do periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, está sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 20 out. 2016.info:eu-repo/semantics/openAccessMaksud, Fabiana Alves NunesKakehasi, Adriana MariaBarbosa, Alfredo José Afonsoengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-05-08T17:51:19Zoai:repositorio.ufop.br:123456789/3825Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-05-08T17:51:19Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. |
title |
Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. |
spellingShingle |
Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. Maksud, Fabiana Alves Nunes Argyrophil cells Endocrine cells Obesity Gastric mucosa Metabolic syndrome |
title_short |
Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. |
title_full |
Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. |
title_fullStr |
Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. |
title_full_unstemmed |
Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. |
title_sort |
Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. |
author |
Maksud, Fabiana Alves Nunes |
author_facet |
Maksud, Fabiana Alves Nunes Kakehasi, Adriana Maria Barbosa, Alfredo José Afonso |
author_role |
author |
author2 |
Kakehasi, Adriana Maria Barbosa, Alfredo José Afonso |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Maksud, Fabiana Alves Nunes Kakehasi, Adriana Maria Barbosa, Alfredo José Afonso |
dc.subject.por.fl_str_mv |
Argyrophil cells Endocrine cells Obesity Gastric mucosa Metabolic syndrome |
topic |
Argyrophil cells Endocrine cells Obesity Gastric mucosa Metabolic syndrome |
description |
Obesity is a multifactorial disorder often associated with many important diseases such as diabetes, hypertension and other metabolic syndrome conditions. Argyrophil cells represent almost the total population of endocrine cells of the human gastric mucosa and some reports have described changes of specific types of these cells in patients with obesity and metabolic syndrome. The present study was designed to evaluate the global population of argyrophil cells of the gastric mucosa of morbidly obese and dyspeptic non-obese patients. Gastric biopsies of antropyloric and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI .40) and 50 non-obese patients (17 dyspeptic overweight and 33 lean individuals) and processed for histology and Grimelius staining for argyrophil cell demonstration. Argyrophil cell density in the oxyntic mucosa of morbidly obese patients was higher in female (238.68 ± 83.71 cells/mm2) than in male patients (179.31 ± 85.96 cells/mm2) and also higher in female (214.20 ± 50.38 cells/mm2) than in male (141.90 ± 61.22 cells/mm2) morbidly obese patients with metabolic syndrome (P = 0.01 and P = 0.02, respectively). In antropyloric mucosa, the main difference in argyrophil cell density was observed between female morbidly obese patients with (167.00 ± 69.30 cells/mm2) and without (234.00 ± 69.54 cells/mm2) metabolic syndrome (P = 0.001). In conclusion, the present results show that the number of gastric argyrophil cells could be under gender influence in patients with morbid obesity. In addition, gastric argyrophil cells seem to behave differently among female morbidly obese patients with and without metabolic syndrome. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2014-11-12T19:20:25Z 2014-11-12T19:20:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
MAKSUD, F. A. N; KAKEHASI, A. M.; BARBOSA, A. J. A. Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. Brazilian Journal of Medical and Biological Research, v. 46, p. 339-342, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400339>. Acesso em: 01 set. 2014. 1414-431X http://www.repositorio.ufop.br/handle/123456789/3825 http://dx.doi.org/10.1590/1414-431X20132609 |
identifier_str_mv |
MAKSUD, F. A. N; KAKEHASI, A. M.; BARBOSA, A. J. A. Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. Brazilian Journal of Medical and Biological Research, v. 46, p. 339-342, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400339>. Acesso em: 01 set. 2014. 1414-431X |
url |
http://www.repositorio.ufop.br/handle/123456789/3825 http://dx.doi.org/10.1590/1414-431X20132609 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
_version_ |
1813002808876597248 |