Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.

Detalhes bibliográficos
Autor(a) principal: Maksud, Fabiana Alves Nunes
Data de Publicação: 2013
Outros Autores: Kakehasi, Adriana Maria, Barbosa, Alfredo José Afonso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/3825
http://dx.doi.org/10.1590/1414-431X20132609
Resumo: Obesity is a multifactorial disorder often associated with many important diseases such as diabetes, hypertension and other metabolic syndrome conditions. Argyrophil cells represent almost the total population of endocrine cells of the human gastric mucosa and some reports have described changes of specific types of these cells in patients with obesity and metabolic syndrome. The present study was designed to evaluate the global population of argyrophil cells of the gastric mucosa of morbidly obese and dyspeptic non-obese patients. Gastric biopsies of antropyloric and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI .40) and 50 non-obese patients (17 dyspeptic overweight and 33 lean individuals) and processed for histology and Grimelius staining for argyrophil cell demonstration. Argyrophil cell density in the oxyntic mucosa of morbidly obese patients was higher in female (238.68 ± 83.71 cells/mm2) than in male patients (179.31 ± 85.96 cells/mm2) and also higher in female (214.20 ± 50.38 cells/mm2) than in male (141.90 ± 61.22 cells/mm2) morbidly obese patients with metabolic syndrome (P = 0.01 and P = 0.02, respectively). In antropyloric mucosa, the main difference in argyrophil cell density was observed between female morbidly obese patients with (167.00 ± 69.30 cells/mm2) and without (234.00 ± 69.54 cells/mm2) metabolic syndrome (P = 0.001). In conclusion, the present results show that the number of gastric argyrophil cells could be under gender influence in patients with morbid obesity. In addition, gastric argyrophil cells seem to behave differently among female morbidly obese patients with and without metabolic syndrome.
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spelling Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.Argyrophil cellsEndocrine cellsObesityGastric mucosaMetabolic syndromeObesity is a multifactorial disorder often associated with many important diseases such as diabetes, hypertension and other metabolic syndrome conditions. Argyrophil cells represent almost the total population of endocrine cells of the human gastric mucosa and some reports have described changes of specific types of these cells in patients with obesity and metabolic syndrome. The present study was designed to evaluate the global population of argyrophil cells of the gastric mucosa of morbidly obese and dyspeptic non-obese patients. Gastric biopsies of antropyloric and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI .40) and 50 non-obese patients (17 dyspeptic overweight and 33 lean individuals) and processed for histology and Grimelius staining for argyrophil cell demonstration. Argyrophil cell density in the oxyntic mucosa of morbidly obese patients was higher in female (238.68 ± 83.71 cells/mm2) than in male patients (179.31 ± 85.96 cells/mm2) and also higher in female (214.20 ± 50.38 cells/mm2) than in male (141.90 ± 61.22 cells/mm2) morbidly obese patients with metabolic syndrome (P = 0.01 and P = 0.02, respectively). In antropyloric mucosa, the main difference in argyrophil cell density was observed between female morbidly obese patients with (167.00 ± 69.30 cells/mm2) and without (234.00 ± 69.54 cells/mm2) metabolic syndrome (P = 0.001). In conclusion, the present results show that the number of gastric argyrophil cells could be under gender influence in patients with morbid obesity. In addition, gastric argyrophil cells seem to behave differently among female morbidly obese patients with and without metabolic syndrome.2014-11-12T19:20:25Z2014-11-12T19:20:25Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMAKSUD, F. A. N; KAKEHASI, A. M.; BARBOSA, A. J. A. Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. Brazilian Journal of Medical and Biological Research, v. 46, p. 339-342, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400339>. Acesso em: 01 set. 2014.1414-431Xhttp://www.repositorio.ufop.br/handle/123456789/3825http://dx.doi.org/10.1590/1414-431X20132609Todo o conteúdo do periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, está sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 20 out. 2016.info:eu-repo/semantics/openAccessMaksud, Fabiana Alves NunesKakehasi, Adriana MariaBarbosa, Alfredo José Afonsoengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-05-08T17:51:19Zoai:repositorio.ufop.br:123456789/3825Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-05-08T17:51:19Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
title Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
spellingShingle Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
Maksud, Fabiana Alves Nunes
Argyrophil cells
Endocrine cells
Obesity
Gastric mucosa
Metabolic syndrome
title_short Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
title_full Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
title_fullStr Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
title_full_unstemmed Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
title_sort Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
author Maksud, Fabiana Alves Nunes
author_facet Maksud, Fabiana Alves Nunes
Kakehasi, Adriana Maria
Barbosa, Alfredo José Afonso
author_role author
author2 Kakehasi, Adriana Maria
Barbosa, Alfredo José Afonso
author2_role author
author
dc.contributor.author.fl_str_mv Maksud, Fabiana Alves Nunes
Kakehasi, Adriana Maria
Barbosa, Alfredo José Afonso
dc.subject.por.fl_str_mv Argyrophil cells
Endocrine cells
Obesity
Gastric mucosa
Metabolic syndrome
topic Argyrophil cells
Endocrine cells
Obesity
Gastric mucosa
Metabolic syndrome
description Obesity is a multifactorial disorder often associated with many important diseases such as diabetes, hypertension and other metabolic syndrome conditions. Argyrophil cells represent almost the total population of endocrine cells of the human gastric mucosa and some reports have described changes of specific types of these cells in patients with obesity and metabolic syndrome. The present study was designed to evaluate the global population of argyrophil cells of the gastric mucosa of morbidly obese and dyspeptic non-obese patients. Gastric biopsies of antropyloric and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI .40) and 50 non-obese patients (17 dyspeptic overweight and 33 lean individuals) and processed for histology and Grimelius staining for argyrophil cell demonstration. Argyrophil cell density in the oxyntic mucosa of morbidly obese patients was higher in female (238.68 ± 83.71 cells/mm2) than in male patients (179.31 ± 85.96 cells/mm2) and also higher in female (214.20 ± 50.38 cells/mm2) than in male (141.90 ± 61.22 cells/mm2) morbidly obese patients with metabolic syndrome (P = 0.01 and P = 0.02, respectively). In antropyloric mucosa, the main difference in argyrophil cell density was observed between female morbidly obese patients with (167.00 ± 69.30 cells/mm2) and without (234.00 ± 69.54 cells/mm2) metabolic syndrome (P = 0.001). In conclusion, the present results show that the number of gastric argyrophil cells could be under gender influence in patients with morbid obesity. In addition, gastric argyrophil cells seem to behave differently among female morbidly obese patients with and without metabolic syndrome.
publishDate 2013
dc.date.none.fl_str_mv 2013
2014-11-12T19:20:25Z
2014-11-12T19:20:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv MAKSUD, F. A. N; KAKEHASI, A. M.; BARBOSA, A. J. A. Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. Brazilian Journal of Medical and Biological Research, v. 46, p. 339-342, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400339>. Acesso em: 01 set. 2014.
1414-431X
http://www.repositorio.ufop.br/handle/123456789/3825
http://dx.doi.org/10.1590/1414-431X20132609
identifier_str_mv MAKSUD, F. A. N; KAKEHASI, A. M.; BARBOSA, A. J. A. Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. Brazilian Journal of Medical and Biological Research, v. 46, p. 339-342, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400339>. Acesso em: 01 set. 2014.
1414-431X
url http://www.repositorio.ufop.br/handle/123456789/3825
http://dx.doi.org/10.1590/1414-431X20132609
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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