Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity.
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/11181 https://doi.org/10.3390/molecules21101342 |
Resumo: | A series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected cell lineages. Benznidazole was used as positive control against T. cruzi and cytotoxicity was determined in mammalian L929 cells. The arylsulfonate xylitan derivative bearing a nitro group displayed the best activity of all the compounds tested, and was slightly more potent than the reference drug benznidazole. The importance of the isopropylidene ketal moiety was established and the greater lipophilicity of these compounds suggests enhancement in cell penetration. |
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Elias, Paula ReginaCoelho, Gleicekelly SilvaXavier, Viviane FloresSales Júnior, Policarpo AdemarRomanha, Alvaro JoséMurta, Silvane Maria FonsecaCarneiro, Claudia MartinsCamilo, Nilton SoaresHilário, Flaviane FranciscoTaylor, Jason Guy2019-05-03T15:06:06Z2019-05-03T15:06:06Z2016ELIAS, P. R. et al. Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. Molecules, v. 21, p. 1-13, 2016. Disponível em: <http://www.mdpi.com/1420-3049/21/10/1342> Acesso em: 15 set. 20171420-3049http://www.repositorio.ufop.br/handle/123456789/11181https://doi.org/10.3390/molecules21101342A series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected cell lineages. Benznidazole was used as positive control against T. cruzi and cytotoxicity was determined in mammalian L929 cells. The arylsulfonate xylitan derivative bearing a nitro group displayed the best activity of all the compounds tested, and was slightly more potent than the reference drug benznidazole. The importance of the isopropylidene ketal moiety was established and the greater lipophilicity of these compounds suggests enhancement in cell penetration.This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). Fonte: o próprio artigo.info:eu-repo/semantics/openAccessXylitolAnhydropentitolTrypomastigoteChagas diseaseAmastigoteSynthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/11181/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_SynthesisXylitanDerivatives.pdfARTIGO_SynthesisXylitanDerivatives.pdfapplication/pdf1153344http://www.repositorio.ufop.br/bitstream/123456789/11181/1/ARTIGO_SynthesisXylitanDerivatives.pdf00a4262842f33d1eef9bc8ccae25a61bMD51123456789/111812019-05-03 11:06:06.031oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-05-03T15:06:06Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. |
title |
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. |
spellingShingle |
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. Elias, Paula Regina Xylitol Anhydropentitol Trypomastigote Chagas disease Amastigote |
title_short |
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. |
title_full |
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. |
title_fullStr |
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. |
title_full_unstemmed |
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. |
title_sort |
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. |
author |
Elias, Paula Regina |
author_facet |
Elias, Paula Regina Coelho, Gleicekelly Silva Xavier, Viviane Flores Sales Júnior, Policarpo Ademar Romanha, Alvaro José Murta, Silvane Maria Fonseca Carneiro, Claudia Martins Camilo, Nilton Soares Hilário, Flaviane Francisco Taylor, Jason Guy |
author_role |
author |
author2 |
Coelho, Gleicekelly Silva Xavier, Viviane Flores Sales Júnior, Policarpo Ademar Romanha, Alvaro José Murta, Silvane Maria Fonseca Carneiro, Claudia Martins Camilo, Nilton Soares Hilário, Flaviane Francisco Taylor, Jason Guy |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Elias, Paula Regina Coelho, Gleicekelly Silva Xavier, Viviane Flores Sales Júnior, Policarpo Ademar Romanha, Alvaro José Murta, Silvane Maria Fonseca Carneiro, Claudia Martins Camilo, Nilton Soares Hilário, Flaviane Francisco Taylor, Jason Guy |
dc.subject.por.fl_str_mv |
Xylitol Anhydropentitol Trypomastigote Chagas disease Amastigote |
topic |
Xylitol Anhydropentitol Trypomastigote Chagas disease Amastigote |
description |
A series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected cell lineages. Benznidazole was used as positive control against T. cruzi and cytotoxicity was determined in mammalian L929 cells. The arylsulfonate xylitan derivative bearing a nitro group displayed the best activity of all the compounds tested, and was slightly more potent than the reference drug benznidazole. The importance of the isopropylidene ketal moiety was established and the greater lipophilicity of these compounds suggests enhancement in cell penetration. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2019-05-03T15:06:06Z |
dc.date.available.fl_str_mv |
2019-05-03T15:06:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ELIAS, P. R. et al. Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. Molecules, v. 21, p. 1-13, 2016. Disponível em: <http://www.mdpi.com/1420-3049/21/10/1342> Acesso em: 15 set. 2017 |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/11181 |
dc.identifier.issn.none.fl_str_mv |
1420-3049 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3390/molecules21101342 |
identifier_str_mv |
ELIAS, P. R. et al. Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity. Molecules, v. 21, p. 1-13, 2016. Disponível em: <http://www.mdpi.com/1420-3049/21/10/1342> Acesso em: 15 set. 2017 1420-3049 |
url |
http://www.repositorio.ufop.br/handle/123456789/11181 https://doi.org/10.3390/molecules21101342 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
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UFOP |
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