Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFPA |
Texto Completo: | http://repositorio.ufpa.br/jspui/handle/2011/4418 http://dx.doi.org/10.1590/S0102-86502013000300005 |
Resumo: | PURPOSE: To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS: The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells. RESULTS: It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage). CONCLUSION: Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor. |
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2013-11-08T13:07:59Z2013-11-08T13:07:59Z2013-03BOTELHO, Nara Macedo, et al. Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 3, p. 185-189, Mar. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000300005. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/4418. Acesso em:.1678-2674http://repositorio.ufpa.br/jspui/handle/2011/4418http://dx.doi.org/10.1590/S0102-86502013000300005PURPOSE: To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS: The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells. RESULTS: It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage). CONCLUSION: Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor.FAPESPA - Fundação Amazônia de Amparo a Estudos e PesquisasQUARESMA, J. A. S. Universidade Federal do ParáengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaSOBRADPECBrasilActa Cirúrgica Brasileirahttp://ref.scielo.org/qdsjc7reponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPACarcinoma 256 de WalkerCerclagem cervicalImunoistoquímicaCopaíbaImmunohistochemistryCervix uteriRatsImmunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsaminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article283185189http://lattes.cnpq.br/5088569652644480http://lattes.cnpq.br/3945331133921104http://lattes.cnpq.br/3361650893566450http://lattes.cnpq.br/5246017785240786http://lattes.cnpq.br/3350166863853054BOTELHO, Nara MacedoCORRÊA, Suelen CostaLOBATO, Rodolfo CostaTEIXEIRA, Renan Kleber CostaQUARESMA, Juarez Antônio Simõeshttp://orcid.org/0000-0002-5079-297Xhttps://orcid.org/0000-0002-6267-9966info:eu-repo/semantics/openAccessORIGINALArticle_ImmunohistochemistryUterine.pdfArticle_ImmunohistochemistryUterine.pdfapplication/pdf472882http://repositorio.ufpa.br/oai/bitstream/2011/4418/1/Article_ImmunohistochemistryUterine.pdff85becb3a5692f0720e38d1fa58a5f7bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81774http://repositorio.ufpa.br/oai/bitstream/2011/4418/2/license.txtf0aa1a71c97d9c3e771021efac6d65e7MD52TEXTArtigo_ImmunohistochemistryUterine.pdf.txtArtigo_ImmunohistochemistryUterine.pdf.txtExtracted texttext/plain15253http://repositorio.ufpa.br/oai/bitstream/2011/4418/3/Artigo_ImmunohistochemistryUterine.pdf.txt1d141077d8f663bc917f01cd133af162MD53Article_ImmunohistochemistryUterine.pdf.txtArticle_ImmunohistochemistryUterine.pdf.txtExtracted texttext/plain15253http://repositorio.ufpa.br/oai/bitstream/2011/4418/4/Article_ImmunohistochemistryUterine.pdf.txt1d141077d8f663bc917f01cd133af162MD542011/44182020-01-30 02:34:18.531oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232020-01-30T05:34:18Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false |
dc.title.en.fl_str_mv |
Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam |
title |
Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam |
spellingShingle |
Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam BOTELHO, Nara Macedo Carcinoma 256 de Walker Cerclagem cervical Imunoistoquímica Copaíba Immunohistochemistry Cervix uteri Rats |
title_short |
Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam |
title_full |
Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam |
title_fullStr |
Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam |
title_full_unstemmed |
Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam |
title_sort |
Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam |
author |
BOTELHO, Nara Macedo |
author_facet |
BOTELHO, Nara Macedo CORRÊA, Suelen Costa LOBATO, Rodolfo Costa TEIXEIRA, Renan Kleber Costa QUARESMA, Juarez Antônio Simões http://orcid.org/0000-0002-5079-297X https://orcid.org/0000-0002-6267-9966 |
author_role |
author |
author2 |
CORRÊA, Suelen Costa LOBATO, Rodolfo Costa TEIXEIRA, Renan Kleber Costa QUARESMA, Juarez Antônio Simões http://orcid.org/0000-0002-5079-297X https://orcid.org/0000-0002-6267-9966 |
author2_role |
author author author author author author |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5088569652644480 http://lattes.cnpq.br/3945331133921104 http://lattes.cnpq.br/3361650893566450 http://lattes.cnpq.br/5246017785240786 http://lattes.cnpq.br/3350166863853054 |
dc.contributor.author.fl_str_mv |
BOTELHO, Nara Macedo CORRÊA, Suelen Costa LOBATO, Rodolfo Costa TEIXEIRA, Renan Kleber Costa QUARESMA, Juarez Antônio Simões http://orcid.org/0000-0002-5079-297X https://orcid.org/0000-0002-6267-9966 |
dc.subject.por.fl_str_mv |
Carcinoma 256 de Walker Cerclagem cervical Imunoistoquímica Copaíba |
topic |
Carcinoma 256 de Walker Cerclagem cervical Imunoistoquímica Copaíba Immunohistochemistry Cervix uteri Rats |
dc.subject.eng.fl_str_mv |
Immunohistochemistry Cervix uteri Rats |
description |
PURPOSE: To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS: The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells. RESULTS: It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage). CONCLUSION: Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor. |
publishDate |
2013 |
dc.date.accessioned.fl_str_mv |
2013-11-08T13:07:59Z |
dc.date.available.fl_str_mv |
2013-11-08T13:07:59Z |
dc.date.issued.fl_str_mv |
2013-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BOTELHO, Nara Macedo, et al. Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 3, p. 185-189, Mar. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000300005. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/4418. Acesso em:. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufpa.br/jspui/handle/2011/4418 |
dc.identifier.issn.none.fl_str_mv |
1678-2674 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502013000300005 |
identifier_str_mv |
BOTELHO, Nara Macedo, et al. Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 3, p. 185-189, Mar. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000300005. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/4418. Acesso em:. 1678-2674 |
url |
http://repositorio.ufpa.br/jspui/handle/2011/4418 http://dx.doi.org/10.1590/S0102-86502013000300005 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Acta Cirúrgica Brasileira |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.publisher.initials.fl_str_mv |
SOBRADPEC |
dc.publisher.country.fl_str_mv |
Brasil |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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