Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma

Detalhes bibliográficos
Autor(a) principal: Machado, Tania Diniz
Data de Publicação: 2017
Outros Autores: Dalle Molle, Roberta, Silveira, Patrícia Pelufo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/73266
Resumo: Introduction: Changes in maternal care can affect offspring’s thyroid hormone T3 levels. Pups from highly caring mothers have higher levels of thyroid hormone T3. In humans, physical abuse in childhood is related to lower levels of T3 in adolescence. This study aimed at verifying if early-life trauma in rodents is correlated with T3 levels in adulthood.Methods: From the second day of life, litters of Wistar rats were subjected to reduced nesting material (Early–Life Stress-ELS) or standard care (Controls). In adult life, the animals were chronically exposed to standard diet or standard diet + palatable diet and plasma T3 levels were measured before and after the exposition to diet.Results: Thyroid hormone T3 levels in adult life correlated negatively with the licking and grooming (LG) scores in the ELS group. This correlation disappeared when the animals had the opportunity to choose between two diets chronically.Conclusion: The adverse environment affected maternal behavior and caused marks on the metabolism of the intervention group (T3), which were reverted by chronic palatable food consumption.Keywords: Trauma; T3; stress
id UFRGS-20_58f5ea33c6f0bf45e9807124d814666c
oai_identifier_str oai:seer.ufrgs.br:article/73266
network_acronym_str UFRGS-20
network_name_str Clinical and Biomedical Research
repository_id_str
spelling Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life traumatraumaT3estresseT3Introduction: Changes in maternal care can affect offspring’s thyroid hormone T3 levels. Pups from highly caring mothers have higher levels of thyroid hormone T3. In humans, physical abuse in childhood is related to lower levels of T3 in adolescence. This study aimed at verifying if early-life trauma in rodents is correlated with T3 levels in adulthood.Methods: From the second day of life, litters of Wistar rats were subjected to reduced nesting material (Early–Life Stress-ELS) or standard care (Controls). In adult life, the animals were chronically exposed to standard diet or standard diet + palatable diet and plasma T3 levels were measured before and after the exposition to diet.Results: Thyroid hormone T3 levels in adult life correlated negatively with the licking and grooming (LG) scores in the ELS group. This correlation disappeared when the animals had the opportunity to choose between two diets chronically.Conclusion: The adverse environment affected maternal behavior and caused marks on the metabolism of the intervention group (T3), which were reverted by chronic palatable food consumption.Keywords: Trauma; T3; stressHCPA/FAMED/UFRGS2017-09-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/73266Clinical & Biomedical Research; Vol. 37 No. 3 (2017): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 37 n. 3 (2017): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/73266/pdf_1Copyright (c) 2017 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessMachado, Tania DinizDalle Molle, RobertaSilveira, Patrícia Pelufo2024-01-19T14:24:36Zoai:seer.ufrgs.br:article/73266Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:24:36Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma
title Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma
spellingShingle Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma
Machado, Tania Diniz
trauma
T3
estresse
T3
title_short Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma
title_full Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma
title_fullStr Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma
title_full_unstemmed Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma
title_sort Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma
author Machado, Tania Diniz
author_facet Machado, Tania Diniz
Dalle Molle, Roberta
Silveira, Patrícia Pelufo
author_role author
author2 Dalle Molle, Roberta
Silveira, Patrícia Pelufo
author2_role author
author
dc.contributor.author.fl_str_mv Machado, Tania Diniz
Dalle Molle, Roberta
Silveira, Patrícia Pelufo
dc.subject.por.fl_str_mv trauma
T3
estresse
T3
topic trauma
T3
estresse
T3
description Introduction: Changes in maternal care can affect offspring’s thyroid hormone T3 levels. Pups from highly caring mothers have higher levels of thyroid hormone T3. In humans, physical abuse in childhood is related to lower levels of T3 in adolescence. This study aimed at verifying if early-life trauma in rodents is correlated with T3 levels in adulthood.Methods: From the second day of life, litters of Wistar rats were subjected to reduced nesting material (Early–Life Stress-ELS) or standard care (Controls). In adult life, the animals were chronically exposed to standard diet or standard diet + palatable diet and plasma T3 levels were measured before and after the exposition to diet.Results: Thyroid hormone T3 levels in adult life correlated negatively with the licking and grooming (LG) scores in the ELS group. This correlation disappeared when the animals had the opportunity to choose between two diets chronically.Conclusion: The adverse environment affected maternal behavior and caused marks on the metabolism of the intervention group (T3), which were reverted by chronic palatable food consumption.Keywords: Trauma; T3; stress
publishDate 2017
dc.date.none.fl_str_mv 2017-09-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/73266
url https://seer.ufrgs.br/index.php/hcpa/article/view/73266
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/73266/pdf_1
dc.rights.driver.fl_str_mv Copyright (c) 2017 Clinical and Biomedical Research
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Clinical and Biomedical Research
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 37 No. 3 (2017): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 37 n. 3 (2017): Clinical and Biomedical Research
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
_version_ 1799767054194049024

Registros relacionados