Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinical and Biomedical Research |
Texto Completo: | https://seer.ufrgs.br/index.php/hcpa/article/view/73266 |
Resumo: | Introduction: Changes in maternal care can affect offspring’s thyroid hormone T3 levels. Pups from highly caring mothers have higher levels of thyroid hormone T3. In humans, physical abuse in childhood is related to lower levels of T3 in adolescence. This study aimed at verifying if early-life trauma in rodents is correlated with T3 levels in adulthood.Methods: From the second day of life, litters of Wistar rats were subjected to reduced nesting material (Early–Life Stress-ELS) or standard care (Controls). In adult life, the animals were chronically exposed to standard diet or standard diet + palatable diet and plasma T3 levels were measured before and after the exposition to diet.Results: Thyroid hormone T3 levels in adult life correlated negatively with the licking and grooming (LG) scores in the ELS group. This correlation disappeared when the animals had the opportunity to choose between two diets chronically.Conclusion: The adverse environment affected maternal behavior and caused marks on the metabolism of the intervention group (T3), which were reverted by chronic palatable food consumption.Keywords: Trauma; T3; stress |
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Clinical and Biomedical Research |
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spelling |
Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life traumatraumaT3estresseT3Introduction: Changes in maternal care can affect offspring’s thyroid hormone T3 levels. Pups from highly caring mothers have higher levels of thyroid hormone T3. In humans, physical abuse in childhood is related to lower levels of T3 in adolescence. This study aimed at verifying if early-life trauma in rodents is correlated with T3 levels in adulthood.Methods: From the second day of life, litters of Wistar rats were subjected to reduced nesting material (Early–Life Stress-ELS) or standard care (Controls). In adult life, the animals were chronically exposed to standard diet or standard diet + palatable diet and plasma T3 levels were measured before and after the exposition to diet.Results: Thyroid hormone T3 levels in adult life correlated negatively with the licking and grooming (LG) scores in the ELS group. This correlation disappeared when the animals had the opportunity to choose between two diets chronically.Conclusion: The adverse environment affected maternal behavior and caused marks on the metabolism of the intervention group (T3), which were reverted by chronic palatable food consumption.Keywords: Trauma; T3; stressHCPA/FAMED/UFRGS2017-09-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/73266Clinical & Biomedical Research; Vol. 37 No. 3 (2017): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 37 n. 3 (2017): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/73266/pdf_1Copyright (c) 2017 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessMachado, Tania DinizDalle Molle, RobertaSilveira, Patrícia Pelufo2024-01-19T14:24:36Zoai:seer.ufrgs.br:article/73266Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:24:36Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma |
title |
Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma |
spellingShingle |
Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma Machado, Tania Diniz trauma T3 estresse T3 |
title_short |
Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma |
title_full |
Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma |
title_fullStr |
Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma |
title_full_unstemmed |
Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma |
title_sort |
Alterations in the hypothalamic–pituitary–thyroid axis in animals submitted to early-life trauma |
author |
Machado, Tania Diniz |
author_facet |
Machado, Tania Diniz Dalle Molle, Roberta Silveira, Patrícia Pelufo |
author_role |
author |
author2 |
Dalle Molle, Roberta Silveira, Patrícia Pelufo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Machado, Tania Diniz Dalle Molle, Roberta Silveira, Patrícia Pelufo |
dc.subject.por.fl_str_mv |
trauma T3 estresse T3 |
topic |
trauma T3 estresse T3 |
description |
Introduction: Changes in maternal care can affect offspring’s thyroid hormone T3 levels. Pups from highly caring mothers have higher levels of thyroid hormone T3. In humans, physical abuse in childhood is related to lower levels of T3 in adolescence. This study aimed at verifying if early-life trauma in rodents is correlated with T3 levels in adulthood.Methods: From the second day of life, litters of Wistar rats were subjected to reduced nesting material (Early–Life Stress-ELS) or standard care (Controls). In adult life, the animals were chronically exposed to standard diet or standard diet + palatable diet and plasma T3 levels were measured before and after the exposition to diet.Results: Thyroid hormone T3 levels in adult life correlated negatively with the licking and grooming (LG) scores in the ELS group. This correlation disappeared when the animals had the opportunity to choose between two diets chronically.Conclusion: The adverse environment affected maternal behavior and caused marks on the metabolism of the intervention group (T3), which were reverted by chronic palatable food consumption.Keywords: Trauma; T3; stress |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Avaliado por Pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/73266 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/73266 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/73266/pdf_1 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Clinical and Biomedical Research info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Clinical and Biomedical Research |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 37 No. 3 (2017): Clinical and Biomedical Research Clinical and Biomedical Research; v. 37 n. 3 (2017): Clinical and Biomedical Research 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
_version_ |
1799767054194049024 |