Synthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfection
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/149421 |
Resumo: | Root canal system disinfection is limited due to anatomical complexities. Better delivery systems of antimicrobial agents are needed to ensure efficient bacteria eradication. The purpose of this study was to design chlorhexidine-containing nanoparticles that could steadily release the drug. The drug chlorhexidine was encapsulated in poly(ethylene glycol)–block–poly(L-lactide) (PEG–b–PLA) to synthesize bilayer nanoparticles. The encapsulation efficiency was determined through thermogravimetric analysis (TGA), and particle characterization was performed through microscopy studies of particle morphology and size. Their antimicrobial effect was assessed over the endodontic pathogen Enterococcus faecalis. The nanoparticles ranged in size from 300–500 nm, which is considered small enough for penetration inside small dentin tubules. The nanoparticles were dispersed in a hydrogel matrix carrier system composed of 1% hydroxyethyl cellulose, and this hydrogel system was observed to have enhanced bacterial inhibition over longer periods of time. Chlorhexidine-containing nanoparticles demonstrate potential as a drug carrier for root canal procedures. Their size and rate of release may allow for sustained inhibition of bacteria in the root canal system. |
id |
UFRGS-2_185db46f30d702d04b833685b734d6d0 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/149421 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Haseeb, RidwanLau, MichaelSheah, MaxMontagner, FranciscoQuiram, GinaPalmer, Kelli L.Stefan, Mihaela C.Rodrigues, Danieli C.2016-11-02T02:16:04Z20161996-1944http://hdl.handle.net/10183/149421000994876Root canal system disinfection is limited due to anatomical complexities. Better delivery systems of antimicrobial agents are needed to ensure efficient bacteria eradication. The purpose of this study was to design chlorhexidine-containing nanoparticles that could steadily release the drug. The drug chlorhexidine was encapsulated in poly(ethylene glycol)–block–poly(L-lactide) (PEG–b–PLA) to synthesize bilayer nanoparticles. The encapsulation efficiency was determined through thermogravimetric analysis (TGA), and particle characterization was performed through microscopy studies of particle morphology and size. Their antimicrobial effect was assessed over the endodontic pathogen Enterococcus faecalis. The nanoparticles ranged in size from 300–500 nm, which is considered small enough for penetration inside small dentin tubules. The nanoparticles were dispersed in a hydrogel matrix carrier system composed of 1% hydroxyethyl cellulose, and this hydrogel system was observed to have enhanced bacterial inhibition over longer periods of time. Chlorhexidine-containing nanoparticles demonstrate potential as a drug carrier for root canal procedures. Their size and rate of release may allow for sustained inhibition of bacteria in the root canal system.application/pdfengMaterials. Basel. Vol. 9, no. 6 (June 2016), e452, p. 1-14ClorexidinaCanais radicularesDesinfecçãoDentin tubulesDentin permeabilityChlorhexidineNanoparticlesEncapsulationSynthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfectionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000994876.pdf000994876.pdfTexto completo (inglês)application/pdf10814836http://www.lume.ufrgs.br/bitstream/10183/149421/1/000994876.pdfdb22c78a563c9e3c7027b889a4a43398MD51TEXT000994876.pdf.txt000994876.pdf.txtExtracted Texttext/plain56946http://www.lume.ufrgs.br/bitstream/10183/149421/2/000994876.pdf.txt4fbcb255eb5791a8d0137d59e831b330MD52THUMBNAIL000994876.pdf.jpg000994876.pdf.jpgGenerated Thumbnailimage/jpeg1804http://www.lume.ufrgs.br/bitstream/10183/149421/3/000994876.pdf.jpg86f5af050992a32be52579b6c284ad2dMD5310183/1494212018-10-29 09:20:00.952oai:www.lume.ufrgs.br:10183/149421Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-29T12:20Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Synthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfection |
title |
Synthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfection |
spellingShingle |
Synthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfection Haseeb, Ridwan Clorexidina Canais radiculares Desinfecção Dentin tubules Dentin permeability Chlorhexidine Nanoparticles Encapsulation |
title_short |
Synthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfection |
title_full |
Synthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfection |
title_fullStr |
Synthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfection |
title_full_unstemmed |
Synthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfection |
title_sort |
Synthesis and characterization of new chlorhexidine-containing nanoparticles for root canal disinfection |
author |
Haseeb, Ridwan |
author_facet |
Haseeb, Ridwan Lau, Michael Sheah, Max Montagner, Francisco Quiram, Gina Palmer, Kelli L. Stefan, Mihaela C. Rodrigues, Danieli C. |
author_role |
author |
author2 |
Lau, Michael Sheah, Max Montagner, Francisco Quiram, Gina Palmer, Kelli L. Stefan, Mihaela C. Rodrigues, Danieli C. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Haseeb, Ridwan Lau, Michael Sheah, Max Montagner, Francisco Quiram, Gina Palmer, Kelli L. Stefan, Mihaela C. Rodrigues, Danieli C. |
dc.subject.por.fl_str_mv |
Clorexidina Canais radiculares Desinfecção |
topic |
Clorexidina Canais radiculares Desinfecção Dentin tubules Dentin permeability Chlorhexidine Nanoparticles Encapsulation |
dc.subject.eng.fl_str_mv |
Dentin tubules Dentin permeability Chlorhexidine Nanoparticles Encapsulation |
description |
Root canal system disinfection is limited due to anatomical complexities. Better delivery systems of antimicrobial agents are needed to ensure efficient bacteria eradication. The purpose of this study was to design chlorhexidine-containing nanoparticles that could steadily release the drug. The drug chlorhexidine was encapsulated in poly(ethylene glycol)–block–poly(L-lactide) (PEG–b–PLA) to synthesize bilayer nanoparticles. The encapsulation efficiency was determined through thermogravimetric analysis (TGA), and particle characterization was performed through microscopy studies of particle morphology and size. Their antimicrobial effect was assessed over the endodontic pathogen Enterococcus faecalis. The nanoparticles ranged in size from 300–500 nm, which is considered small enough for penetration inside small dentin tubules. The nanoparticles were dispersed in a hydrogel matrix carrier system composed of 1% hydroxyethyl cellulose, and this hydrogel system was observed to have enhanced bacterial inhibition over longer periods of time. Chlorhexidine-containing nanoparticles demonstrate potential as a drug carrier for root canal procedures. Their size and rate of release may allow for sustained inhibition of bacteria in the root canal system. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-11-02T02:16:04Z |
dc.date.issued.fl_str_mv |
2016 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/149421 |
dc.identifier.issn.pt_BR.fl_str_mv |
1996-1944 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000994876 |
identifier_str_mv |
1996-1944 000994876 |
url |
http://hdl.handle.net/10183/149421 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Materials. Basel. Vol. 9, no. 6 (June 2016), e452, p. 1-14 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/149421/1/000994876.pdf http://www.lume.ufrgs.br/bitstream/10183/149421/2/000994876.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/149421/3/000994876.pdf.jpg |
bitstream.checksum.fl_str_mv |
db22c78a563c9e3c7027b889a4a43398 4fbcb255eb5791a8d0137d59e831b330 86f5af050992a32be52579b6c284ad2d |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224910185431040 |