Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/178502 |
Resumo: | Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs. These were self-assembled through water-in-oil emulsion from poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA), a di-block copolymer, with one hydrophilic segment and another hydrophobic. The resulting TNPs were physicochemically characterized and their antimicrobial effectiveness was evaluated against Enterococcus faecalis using a broth inhibition method. The hydrophilic interior of the TNPs successfully entrapped chlorhexidine digluconate. The resulting TNPs had particle size ranging from 140–295 nm, with adequate encapsulation efficiency, and maintained inhibition of bacteria over 21 days. The delivery of antibacterial irrigants throughout the dentinal matrix by employing the TNP system described in this work may be an effective alternative to improve root canal disinfection. |
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Quiram, GinaMontagner, FranciscoPalmer, Kelli L.Stefan, Mihaela C.Washington, Katherine E.Rodrigues, Danieli C.2018-05-18T02:27:18Z20182079-4983http://hdl.handle.net/10183/178502001067445Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs. These were self-assembled through water-in-oil emulsion from poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA), a di-block copolymer, with one hydrophilic segment and another hydrophobic. The resulting TNPs were physicochemically characterized and their antimicrobial effectiveness was evaluated against Enterococcus faecalis using a broth inhibition method. The hydrophilic interior of the TNPs successfully entrapped chlorhexidine digluconate. The resulting TNPs had particle size ranging from 140–295 nm, with adequate encapsulation efficiency, and maintained inhibition of bacteria over 21 days. The delivery of antibacterial irrigants throughout the dentinal matrix by employing the TNP system described in this work may be an effective alternative to improve root canal disinfection.application/pdfengJournal of Functional Biomaterials. Basel. Vol. 9, no. 2 (June 2018), e29, p. 1-14ClorexidinaCanais radicularesDesinfecçãoChlorhexidineDentin permeabilityDentin tubulesDrug encapsulationPolymeric nanoparticlesPoly(ethylene glycol)-b-poly(lactic acid)Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatmentEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001067445.pdf001067445.pdfTexto completo (inglês)application/pdf22180892http://www.lume.ufrgs.br/bitstream/10183/178502/1/001067445.pdfa3261aba2311ed35a60481c1135cb0dcMD51TEXT001067445.pdf.txt001067445.pdf.txtExtracted Texttext/plain49815http://www.lume.ufrgs.br/bitstream/10183/178502/2/001067445.pdf.txta1bffd0bb2068291bd9da933747bad49MD5210183/1785022018-05-19 03:17:42.4786oai:www.lume.ufrgs.br:10183/178502Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-05-19T06:17:42Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment |
title |
Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment |
spellingShingle |
Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment Quiram, Gina Clorexidina Canais radiculares Desinfecção Chlorhexidine Dentin permeability Dentin tubules Drug encapsulation Polymeric nanoparticles Poly(ethylene glycol)-b-poly(lactic acid) |
title_short |
Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment |
title_full |
Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment |
title_fullStr |
Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment |
title_full_unstemmed |
Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment |
title_sort |
Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment |
author |
Quiram, Gina |
author_facet |
Quiram, Gina Montagner, Francisco Palmer, Kelli L. Stefan, Mihaela C. Washington, Katherine E. Rodrigues, Danieli C. |
author_role |
author |
author2 |
Montagner, Francisco Palmer, Kelli L. Stefan, Mihaela C. Washington, Katherine E. Rodrigues, Danieli C. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Quiram, Gina Montagner, Francisco Palmer, Kelli L. Stefan, Mihaela C. Washington, Katherine E. Rodrigues, Danieli C. |
dc.subject.por.fl_str_mv |
Clorexidina Canais radiculares Desinfecção |
topic |
Clorexidina Canais radiculares Desinfecção Chlorhexidine Dentin permeability Dentin tubules Drug encapsulation Polymeric nanoparticles Poly(ethylene glycol)-b-poly(lactic acid) |
dc.subject.eng.fl_str_mv |
Chlorhexidine Dentin permeability Dentin tubules Drug encapsulation Polymeric nanoparticles Poly(ethylene glycol)-b-poly(lactic acid) |
description |
Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs. These were self-assembled through water-in-oil emulsion from poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA), a di-block copolymer, with one hydrophilic segment and another hydrophobic. The resulting TNPs were physicochemically characterized and their antimicrobial effectiveness was evaluated against Enterococcus faecalis using a broth inhibition method. The hydrophilic interior of the TNPs successfully entrapped chlorhexidine digluconate. The resulting TNPs had particle size ranging from 140–295 nm, with adequate encapsulation efficiency, and maintained inhibition of bacteria over 21 days. The delivery of antibacterial irrigants throughout the dentinal matrix by employing the TNP system described in this work may be an effective alternative to improve root canal disinfection. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-05-18T02:27:18Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/178502 |
dc.identifier.issn.pt_BR.fl_str_mv |
2079-4983 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001067445 |
identifier_str_mv |
2079-4983 001067445 |
url |
http://hdl.handle.net/10183/178502 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of Functional Biomaterials. Basel. Vol. 9, no. 2 (June 2018), e29, p. 1-14 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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