Safer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/225918 |
Resumo: | Introduction: Glycemic variability during nutritional therapy in critically ill patients is associated with morbidity and mortality. A low-carbohydrate diet can be help avoid glycemic oscillation in patients under enteral nutrition; however, it is unclear whether the presence of fructose interferes with glycemic variability. Aim: Our study aimed to evaluate the effect of two diabetes-specific diets (fructose-based versus maltodextrin-based) on the glycemic variability of critically ill patients. Methods: This was a randomized, active-controlled, double-blinded crossover clinical trial comparing diabetes-specific enteral formula with fructose versus without fructose. Patients under enteral nutrition who developed hyperglycemia during their intensive care unit stay were included. Patients were randomized to receive one of two diets for 2 days before switching to the other diet. A capillary blood sample was taken every 4 h, and glycemic variability was defined as the difference between each time point. Results: Twenty-five patients completed both formulas. Patients that underwent the fructose- based diet reduced their glycemic variability by 6.30 mg/dL relative to those that received the maltodextrin-based diet (95%CI -13.86 to 1.26 mg/dL, p = 0.101 for between-group differences). This effect was seen without any complications. Conclusion: A diabetes-specific enteral formula with fructose had no difference in glycemic variability in critically ill patients versus a diabetes-specific enteral formula without fructose. |
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Kumbier, Magali Cristini CasolaTeixeira, CassianoCamey, Suzi AlvesAlmeida, Jussara Carnevale de2021-08-19T04:33:46Z2021http://hdl.handle.net/10183/225918001130385Introduction: Glycemic variability during nutritional therapy in critically ill patients is associated with morbidity and mortality. A low-carbohydrate diet can be help avoid glycemic oscillation in patients under enteral nutrition; however, it is unclear whether the presence of fructose interferes with glycemic variability. Aim: Our study aimed to evaluate the effect of two diabetes-specific diets (fructose-based versus maltodextrin-based) on the glycemic variability of critically ill patients. Methods: This was a randomized, active-controlled, double-blinded crossover clinical trial comparing diabetes-specific enteral formula with fructose versus without fructose. Patients under enteral nutrition who developed hyperglycemia during their intensive care unit stay were included. Patients were randomized to receive one of two diets for 2 days before switching to the other diet. A capillary blood sample was taken every 4 h, and glycemic variability was defined as the difference between each time point. Results: Twenty-five patients completed both formulas. Patients that underwent the fructose- based diet reduced their glycemic variability by 6.30 mg/dL relative to those that received the maltodextrin-based diet (95%CI -13.86 to 1.26 mg/dL, p = 0.101 for between-group differences). This effect was seen without any complications. Conclusion: A diabetes-specific enteral formula with fructose had no difference in glycemic variability in critically ill patients versus a diabetes-specific enteral formula without fructose.application/pdfengEC Nutrition. London. Vol. 16, n. 8 (2021), p. 8-15Nutrição enteralFrutoseDiabetes mellitusGlicoseEnteral nutritionCritically illFructoseDiabetes mellitusBlood glucoseSafer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trialEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001130385.pdf.txt001130385.pdf.txtExtracted Texttext/plain25599http://www.lume.ufrgs.br/bitstream/10183/225918/2/001130385.pdf.txtfa72c8216738084dec323b52383d9882MD52ORIGINAL001130385.pdfTexto completo (inglês)application/pdf432721http://www.lume.ufrgs.br/bitstream/10183/225918/1/001130385.pdf97a8d6e65fd1c0d219fc31721f3772a2MD5110183/2259182021-11-20 05:58:09.833651oai:www.lume.ufrgs.br:10183/225918Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T07:58:09Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Safer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trial |
title |
Safer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trial |
spellingShingle |
Safer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trial Kumbier, Magali Cristini Casola Nutrição enteral Frutose Diabetes mellitus Glicose Enteral nutrition Critically ill Fructose Diabetes mellitus Blood glucose |
title_short |
Safer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trial |
title_full |
Safer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trial |
title_fullStr |
Safer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trial |
title_full_unstemmed |
Safer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trial |
title_sort |
Safer glycemic control using a fructose-based enteral formula : a randomized crossover clinical trial |
author |
Kumbier, Magali Cristini Casola |
author_facet |
Kumbier, Magali Cristini Casola Teixeira, Cassiano Camey, Suzi Alves Almeida, Jussara Carnevale de |
author_role |
author |
author2 |
Teixeira, Cassiano Camey, Suzi Alves Almeida, Jussara Carnevale de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Kumbier, Magali Cristini Casola Teixeira, Cassiano Camey, Suzi Alves Almeida, Jussara Carnevale de |
dc.subject.por.fl_str_mv |
Nutrição enteral Frutose Diabetes mellitus Glicose |
topic |
Nutrição enteral Frutose Diabetes mellitus Glicose Enteral nutrition Critically ill Fructose Diabetes mellitus Blood glucose |
dc.subject.eng.fl_str_mv |
Enteral nutrition Critically ill Fructose Diabetes mellitus Blood glucose |
description |
Introduction: Glycemic variability during nutritional therapy in critically ill patients is associated with morbidity and mortality. A low-carbohydrate diet can be help avoid glycemic oscillation in patients under enteral nutrition; however, it is unclear whether the presence of fructose interferes with glycemic variability. Aim: Our study aimed to evaluate the effect of two diabetes-specific diets (fructose-based versus maltodextrin-based) on the glycemic variability of critically ill patients. Methods: This was a randomized, active-controlled, double-blinded crossover clinical trial comparing diabetes-specific enteral formula with fructose versus without fructose. Patients under enteral nutrition who developed hyperglycemia during their intensive care unit stay were included. Patients were randomized to receive one of two diets for 2 days before switching to the other diet. A capillary blood sample was taken every 4 h, and glycemic variability was defined as the difference between each time point. Results: Twenty-five patients completed both formulas. Patients that underwent the fructose- based diet reduced their glycemic variability by 6.30 mg/dL relative to those that received the maltodextrin-based diet (95%CI -13.86 to 1.26 mg/dL, p = 0.101 for between-group differences). This effect was seen without any complications. Conclusion: A diabetes-specific enteral formula with fructose had no difference in glycemic variability in critically ill patients versus a diabetes-specific enteral formula without fructose. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-08-19T04:33:46Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/225918 |
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001130385 |
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eng |
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eng |
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EC Nutrition. London. Vol. 16, n. 8 (2021), p. 8-15 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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