Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation

Detalhes bibliográficos
Autor(a) principal: Beck, Ruy Carlos Ruver
Data de Publicação: 2006
Outros Autores: Haas, Sandra Elisa, Guterres, Silvia Stanisçuaski, Ré, Maria Inês, Benvenutti, Edilson Valmir, Pohlmann, Adriana Raffin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/72853
Resumo: The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 32. Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.
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spelling Beck, Ruy Carlos RuverHaas, Sandra ElisaGuterres, Silvia StanisçuaskiRé, Maria InêsBenvenutti, Edilson ValmirPohlmann, Adriana Raffin2013-07-02T01:43:09Z20060100-4042http://hdl.handle.net/10183/72853000552250The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 32. Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.application/pdfengQuímica nova. Vol. 29, n.5 (Sept./Oct. 2006), p. 990-996MicroparticulasNanoesferasNanocoatingNanoparticleMicroparticleNanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000552250.pdf000552250.pdfTexto completo (inglês)application/pdf1204615http://www.lume.ufrgs.br/bitstream/10183/72853/1/000552250.pdf9f81c78ced912c205b6cbd5357e2e6e9MD51TEXT000552250.pdf.txt000552250.pdf.txtExtracted Texttext/plain39162http://www.lume.ufrgs.br/bitstream/10183/72853/2/000552250.pdf.txtbcbd5d80c70bbc8bd8d375882052a13bMD52THUMBNAIL000552250.pdf.jpg000552250.pdf.jpgGenerated Thumbnailimage/jpeg1982http://www.lume.ufrgs.br/bitstream/10183/72853/3/000552250.pdf.jpga961451953200f2dadaf46d11b141278MD5310183/728532018-10-15 08:11:35.947oai:www.lume.ufrgs.br:10183/72853Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-15T11:11:35Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
title Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
spellingShingle Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
Beck, Ruy Carlos Ruver
Microparticulas
Nanoesferas
Nanocoating
Nanoparticle
Microparticle
title_short Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
title_full Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
title_fullStr Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
title_full_unstemmed Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
title_sort Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
author Beck, Ruy Carlos Ruver
author_facet Beck, Ruy Carlos Ruver
Haas, Sandra Elisa
Guterres, Silvia Stanisçuaski
Ré, Maria Inês
Benvenutti, Edilson Valmir
Pohlmann, Adriana Raffin
author_role author
author2 Haas, Sandra Elisa
Guterres, Silvia Stanisçuaski
Ré, Maria Inês
Benvenutti, Edilson Valmir
Pohlmann, Adriana Raffin
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Beck, Ruy Carlos Ruver
Haas, Sandra Elisa
Guterres, Silvia Stanisçuaski
Ré, Maria Inês
Benvenutti, Edilson Valmir
Pohlmann, Adriana Raffin
dc.subject.por.fl_str_mv Microparticulas
Nanoesferas
topic Microparticulas
Nanoesferas
Nanocoating
Nanoparticle
Microparticle
dc.subject.eng.fl_str_mv Nanocoating
Nanoparticle
Microparticle
description The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 32. Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-07-02T01:43:09Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/72853
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.nrb.pt_BR.fl_str_mv 000552250
identifier_str_mv 0100-4042
000552250
url http://hdl.handle.net/10183/72853
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Química nova. Vol. 29, n.5 (Sept./Oct. 2006), p. 990-996
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reponame_str Repositório Institucional da UFRGS
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