Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation

Detalhes bibliográficos
Autor(a) principal: Beck,Ruy Carlos R.
Data de Publicação: 2006
Outros Autores: Haas,Sandra Elisa, Guterres,Silvia Stanisçuaski, Ré,Maria Inês, Benvenutti,Edilson V., Pohlmann,Adriana Raffin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000500019
Resumo: The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 3². Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.
id SBQ-3_f2aa819e0b854f4675102cc77e4cf4e1
oai_identifier_str oai:scielo:S0100-40422006000500019
network_acronym_str SBQ-3
network_name_str Química Nova (Online)
repository_id_str
spelling Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluationnanocoatingnanoparticlemicroparticleThe influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 3². Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.Sociedade Brasileira de Química2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000500019Química Nova v.29 n.5 2006reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422006000500019info:eu-repo/semantics/openAccessBeck,Ruy Carlos R.Haas,Sandra ElisaGuterres,Silvia StanisçuaskiRé,Maria InêsBenvenutti,Edilson V.Pohlmann,Adriana Raffineng2011-09-06T00:00:00Zoai:scielo:S0100-40422006000500019Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-09-06T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
title Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
spellingShingle Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
Beck,Ruy Carlos R.
nanocoating
nanoparticle
microparticle
title_short Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
title_full Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
title_fullStr Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
title_full_unstemmed Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
title_sort Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
author Beck,Ruy Carlos R.
author_facet Beck,Ruy Carlos R.
Haas,Sandra Elisa
Guterres,Silvia Stanisçuaski
Ré,Maria Inês
Benvenutti,Edilson V.
Pohlmann,Adriana Raffin
author_role author
author2 Haas,Sandra Elisa
Guterres,Silvia Stanisçuaski
Ré,Maria Inês
Benvenutti,Edilson V.
Pohlmann,Adriana Raffin
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Beck,Ruy Carlos R.
Haas,Sandra Elisa
Guterres,Silvia Stanisçuaski
Ré,Maria Inês
Benvenutti,Edilson V.
Pohlmann,Adriana Raffin
dc.subject.por.fl_str_mv nanocoating
nanoparticle
microparticle
topic nanocoating
nanoparticle
microparticle
description The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 3². Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000500019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000500019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422006000500019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.29 n.5 2006
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318105684344832

Registros relacionados