Environmental enrichment modulates the response to chronic stress in zebrafish
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/174443 |
Resumo: | Several studies have shown that manipulations to the housing environment modulate susceptibility to stress in laboratory animals, mainly in rodents. Environmental enrichment (EE) is one such manipulation that promotes neuroprotection and neurogenesis, besides affecting behaviors such as drug self-administration. Zebrafish are a popular and useful animal model for behavioral neuroscience studies; however, studies evaluating the impact of housing conditions in this species are scarce. In this study, we verified the effects of EE on behavioral (novel tank test) and biochemical [cortisol and reactive oxygen species (ROS)] parameters in zebrafish submitted to unpredictable chronic stress (UCS). Consistent with our previous findings, UCS increased anxiety-like behavior, cortisol and ROS levels in zebrafish. EE for 21 or 28 days attenuated the effects induced by UCS on behavior and cortisol, and prevented the effects on ROS levels. Our findings reinforce the idea that EE exerts neuromodulatory effects across species, reducing vulnerability to stress and its biochemical impact. Also, these results indicate that zebrafish is a suitable model animal to study the behavioral effects and neurobiological mechanisms related to EE. |
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Marcon, Matheus FelipeMocelin, Ricieri NaueBenvenutti, RadharaniSilva, Tales CostaHerrmann, Ana PaulaOliveira, Diogo Losch deKoakoski, GessiBarcellos, Leonardo Jose GilPiato, Angelo Luis Stapassoli2018-04-05T02:26:05Z20180022-0949http://hdl.handle.net/10183/174443001063381Several studies have shown that manipulations to the housing environment modulate susceptibility to stress in laboratory animals, mainly in rodents. Environmental enrichment (EE) is one such manipulation that promotes neuroprotection and neurogenesis, besides affecting behaviors such as drug self-administration. Zebrafish are a popular and useful animal model for behavioral neuroscience studies; however, studies evaluating the impact of housing conditions in this species are scarce. In this study, we verified the effects of EE on behavioral (novel tank test) and biochemical [cortisol and reactive oxygen species (ROS)] parameters in zebrafish submitted to unpredictable chronic stress (UCS). Consistent with our previous findings, UCS increased anxiety-like behavior, cortisol and ROS levels in zebrafish. EE for 21 or 28 days attenuated the effects induced by UCS on behavior and cortisol, and prevented the effects on ROS levels. Our findings reinforce the idea that EE exerts neuromodulatory effects across species, reducing vulnerability to stress and its biochemical impact. Also, these results indicate that zebrafish is a suitable model animal to study the behavioral effects and neurobiological mechanisms related to EE.application/pdfengThe journal of experimental biology. V. 221, pt.4 (Feb. 2018), jeb176735, [7] p.HidrocortisonaEstresse oxidativoComportamentoPeixe-zebraNeuromodulationBehaviorOxidative stressCortisolEnvironmental enrichment modulates the response to chronic stress in zebrafishEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001063381.pdf001063381.pdfTexto completo (inglês)application/pdf674936http://www.lume.ufrgs.br/bitstream/10183/174443/1/001063381.pdf44e35bbdc79aa503da9ce9ca268f2316MD51TEXT001063381.pdf.txt001063381.pdf.txtExtracted Texttext/plain42562http://www.lume.ufrgs.br/bitstream/10183/174443/2/001063381.pdf.txt2b913f727b998504aee25cc6b7b967a6MD52THUMBNAIL001063381.pdf.jpg001063381.pdf.jpgGenerated Thumbnailimage/jpeg2188http://www.lume.ufrgs.br/bitstream/10183/174443/3/001063381.pdf.jpgb1ad1aefa7d1a09756af57713078bc43MD5310183/1744432021-03-09 04:47:08.080842oai:www.lume.ufrgs.br:10183/174443Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-03-09T07:47:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Environmental enrichment modulates the response to chronic stress in zebrafish |
title |
Environmental enrichment modulates the response to chronic stress in zebrafish |
spellingShingle |
Environmental enrichment modulates the response to chronic stress in zebrafish Marcon, Matheus Felipe Hidrocortisona Estresse oxidativo Comportamento Peixe-zebra Neuromodulation Behavior Oxidative stress Cortisol |
title_short |
Environmental enrichment modulates the response to chronic stress in zebrafish |
title_full |
Environmental enrichment modulates the response to chronic stress in zebrafish |
title_fullStr |
Environmental enrichment modulates the response to chronic stress in zebrafish |
title_full_unstemmed |
Environmental enrichment modulates the response to chronic stress in zebrafish |
title_sort |
Environmental enrichment modulates the response to chronic stress in zebrafish |
author |
Marcon, Matheus Felipe |
author_facet |
Marcon, Matheus Felipe Mocelin, Ricieri Naue Benvenutti, Radharani Silva, Tales Costa Herrmann, Ana Paula Oliveira, Diogo Losch de Koakoski, Gessi Barcellos, Leonardo Jose Gil Piato, Angelo Luis Stapassoli |
author_role |
author |
author2 |
Mocelin, Ricieri Naue Benvenutti, Radharani Silva, Tales Costa Herrmann, Ana Paula Oliveira, Diogo Losch de Koakoski, Gessi Barcellos, Leonardo Jose Gil Piato, Angelo Luis Stapassoli |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Marcon, Matheus Felipe Mocelin, Ricieri Naue Benvenutti, Radharani Silva, Tales Costa Herrmann, Ana Paula Oliveira, Diogo Losch de Koakoski, Gessi Barcellos, Leonardo Jose Gil Piato, Angelo Luis Stapassoli |
dc.subject.por.fl_str_mv |
Hidrocortisona Estresse oxidativo Comportamento Peixe-zebra |
topic |
Hidrocortisona Estresse oxidativo Comportamento Peixe-zebra Neuromodulation Behavior Oxidative stress Cortisol |
dc.subject.eng.fl_str_mv |
Neuromodulation Behavior Oxidative stress Cortisol |
description |
Several studies have shown that manipulations to the housing environment modulate susceptibility to stress in laboratory animals, mainly in rodents. Environmental enrichment (EE) is one such manipulation that promotes neuroprotection and neurogenesis, besides affecting behaviors such as drug self-administration. Zebrafish are a popular and useful animal model for behavioral neuroscience studies; however, studies evaluating the impact of housing conditions in this species are scarce. In this study, we verified the effects of EE on behavioral (novel tank test) and biochemical [cortisol and reactive oxygen species (ROS)] parameters in zebrafish submitted to unpredictable chronic stress (UCS). Consistent with our previous findings, UCS increased anxiety-like behavior, cortisol and ROS levels in zebrafish. EE for 21 or 28 days attenuated the effects induced by UCS on behavior and cortisol, and prevented the effects on ROS levels. Our findings reinforce the idea that EE exerts neuromodulatory effects across species, reducing vulnerability to stress and its biochemical impact. Also, these results indicate that zebrafish is a suitable model animal to study the behavioral effects and neurobiological mechanisms related to EE. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-04-05T02:26:05Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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0022-0949 |
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001063381 |
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http://hdl.handle.net/10183/174443 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
The journal of experimental biology. V. 221, pt.4 (Feb. 2018), jeb176735, [7] p. |
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openAccess |
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application/pdf |
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