Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations

Detalhes bibliográficos
Autor(a) principal: Mombach, Jose Carlos Merino
Data de Publicação: 1995
Outros Autores: Glazier, James Alexander, Raphael, Richard C., Zajac, Mark
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/100077
Resumo: We study the effect of inhibition of cell-membrane ruffling on cell sorting in experiments and simulations. We use aggregates of neural retinal and pigmented retinal cells obtained from chicken embryos and inhibit membrane ruffling by adding the drug cytochalasin B to the culture medium. Simulations using the large-Q Potts model with differential adhesivity, with the simulation temperature controlling the membrane ruffling amplitude, agree quantitatively with the experimental results for both normal and low fluctuation sorting, providing strong support for the validity of the model. In both cases, inhibition of ruffling prevents large scale cell sorting.
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spelling Mombach, Jose Carlos MerinoGlazier, James AlexanderRaphael, Richard C.Zajac, Mark2014-08-12T02:10:16Z19950031-9007http://hdl.handle.net/10183/100077000084868We study the effect of inhibition of cell-membrane ruffling on cell sorting in experiments and simulations. We use aggregates of neural retinal and pigmented retinal cells obtained from chicken embryos and inhibit membrane ruffling by adding the drug cytochalasin B to the culture medium. Simulations using the large-Q Potts model with differential adhesivity, with the simulation temperature controlling the membrane ruffling amplitude, agree quantitatively with the experimental results for both normal and low fluctuation sorting, providing strong support for the validity of the model. In both cases, inhibition of ruffling prevents large scale cell sorting.application/pdfengPhysical Review Letters. Woodbury. Vol. 75, n. 11 (Sept. 1995), p. 2244-2247Física da matéria condensadaBiofísicaQuantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuationsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000084868.pdf000084868.pdfTexto completo (inglês)application/pdf821955http://www.lume.ufrgs.br/bitstream/10183/100077/1/000084868.pdfdea90eaa40c3eb1be9f9b524d0030b5fMD51TEXT000084868.pdf.txt000084868.pdf.txtExtracted Texttext/plain19295http://www.lume.ufrgs.br/bitstream/10183/100077/2/000084868.pdf.txtb5d217f9916fc2154e434fb4f258f79bMD52THUMBNAIL000084868.pdf.jpg000084868.pdf.jpgGenerated Thumbnailimage/jpeg2019http://www.lume.ufrgs.br/bitstream/10183/100077/3/000084868.pdf.jpg77224afde57ebaa19d108b9d54b83a80MD5310183/1000772018-10-22 08:52:43.591oai:www.lume.ufrgs.br:10183/100077Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-22T11:52:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations
title Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations
spellingShingle Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations
Mombach, Jose Carlos Merino
Física da matéria condensada
Biofísica
title_short Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations
title_full Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations
title_fullStr Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations
title_full_unstemmed Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations
title_sort Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations
author Mombach, Jose Carlos Merino
author_facet Mombach, Jose Carlos Merino
Glazier, James Alexander
Raphael, Richard C.
Zajac, Mark
author_role author
author2 Glazier, James Alexander
Raphael, Richard C.
Zajac, Mark
author2_role author
author
author
dc.contributor.author.fl_str_mv Mombach, Jose Carlos Merino
Glazier, James Alexander
Raphael, Richard C.
Zajac, Mark
dc.subject.por.fl_str_mv Física da matéria condensada
Biofísica
topic Física da matéria condensada
Biofísica
description We study the effect of inhibition of cell-membrane ruffling on cell sorting in experiments and simulations. We use aggregates of neural retinal and pigmented retinal cells obtained from chicken embryos and inhibit membrane ruffling by adding the drug cytochalasin B to the culture medium. Simulations using the large-Q Potts model with differential adhesivity, with the simulation temperature controlling the membrane ruffling amplitude, agree quantitatively with the experimental results for both normal and low fluctuation sorting, providing strong support for the validity of the model. In both cases, inhibition of ruffling prevents large scale cell sorting.
publishDate 1995
dc.date.issued.fl_str_mv 1995
dc.date.accessioned.fl_str_mv 2014-08-12T02:10:16Z
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dc.identifier.issn.pt_BR.fl_str_mv 0031-9007
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Physical Review Letters. Woodbury. Vol. 75, n. 11 (Sept. 1995), p. 2244-2247
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