Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/100077 |
Resumo: | We study the effect of inhibition of cell-membrane ruffling on cell sorting in experiments and simulations. We use aggregates of neural retinal and pigmented retinal cells obtained from chicken embryos and inhibit membrane ruffling by adding the drug cytochalasin B to the culture medium. Simulations using the large-Q Potts model with differential adhesivity, with the simulation temperature controlling the membrane ruffling amplitude, agree quantitatively with the experimental results for both normal and low fluctuation sorting, providing strong support for the validity of the model. In both cases, inhibition of ruffling prevents large scale cell sorting. |
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Mombach, Jose Carlos MerinoGlazier, James AlexanderRaphael, Richard C.Zajac, Mark2014-08-12T02:10:16Z19950031-9007http://hdl.handle.net/10183/100077000084868We study the effect of inhibition of cell-membrane ruffling on cell sorting in experiments and simulations. We use aggregates of neural retinal and pigmented retinal cells obtained from chicken embryos and inhibit membrane ruffling by adding the drug cytochalasin B to the culture medium. Simulations using the large-Q Potts model with differential adhesivity, with the simulation temperature controlling the membrane ruffling amplitude, agree quantitatively with the experimental results for both normal and low fluctuation sorting, providing strong support for the validity of the model. In both cases, inhibition of ruffling prevents large scale cell sorting.application/pdfengPhysical Review Letters. Woodbury. Vol. 75, n. 11 (Sept. 1995), p. 2244-2247Física da matéria condensadaBiofísicaQuantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuationsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000084868.pdf000084868.pdfTexto completo (inglês)application/pdf821955http://www.lume.ufrgs.br/bitstream/10183/100077/1/000084868.pdfdea90eaa40c3eb1be9f9b524d0030b5fMD51TEXT000084868.pdf.txt000084868.pdf.txtExtracted Texttext/plain19295http://www.lume.ufrgs.br/bitstream/10183/100077/2/000084868.pdf.txtb5d217f9916fc2154e434fb4f258f79bMD52THUMBNAIL000084868.pdf.jpg000084868.pdf.jpgGenerated Thumbnailimage/jpeg2019http://www.lume.ufrgs.br/bitstream/10183/100077/3/000084868.pdf.jpg77224afde57ebaa19d108b9d54b83a80MD5310183/1000772018-10-22 08:52:43.591oai:www.lume.ufrgs.br:10183/100077Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-22T11:52:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations |
title |
Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations |
spellingShingle |
Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations Mombach, Jose Carlos Merino Física da matéria condensada Biofísica |
title_short |
Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations |
title_full |
Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations |
title_fullStr |
Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations |
title_full_unstemmed |
Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations |
title_sort |
Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations |
author |
Mombach, Jose Carlos Merino |
author_facet |
Mombach, Jose Carlos Merino Glazier, James Alexander Raphael, Richard C. Zajac, Mark |
author_role |
author |
author2 |
Glazier, James Alexander Raphael, Richard C. Zajac, Mark |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Mombach, Jose Carlos Merino Glazier, James Alexander Raphael, Richard C. Zajac, Mark |
dc.subject.por.fl_str_mv |
Física da matéria condensada Biofísica |
topic |
Física da matéria condensada Biofísica |
description |
We study the effect of inhibition of cell-membrane ruffling on cell sorting in experiments and simulations. We use aggregates of neural retinal and pigmented retinal cells obtained from chicken embryos and inhibit membrane ruffling by adding the drug cytochalasin B to the culture medium. Simulations using the large-Q Potts model with differential adhesivity, with the simulation temperature controlling the membrane ruffling amplitude, agree quantitatively with the experimental results for both normal and low fluctuation sorting, providing strong support for the validity of the model. In both cases, inhibition of ruffling prevents large scale cell sorting. |
publishDate |
1995 |
dc.date.issued.fl_str_mv |
1995 |
dc.date.accessioned.fl_str_mv |
2014-08-12T02:10:16Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/100077 |
dc.identifier.issn.pt_BR.fl_str_mv |
0031-9007 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000084868 |
identifier_str_mv |
0031-9007 000084868 |
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http://hdl.handle.net/10183/100077 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Physical Review Letters. Woodbury. Vol. 75, n. 11 (Sept. 1995), p. 2244-2247 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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