Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages

Detalhes bibliográficos
Autor(a) principal: Sant'Ana, Alexia Nedel
Data de Publicação: 2021
Outros Autores: Araujo, Anelise Bergmann, Gonçalves, Fabiany da Costa, Paz, Ana Helena da Rosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/233668
Resumo: Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cells that have great potential as cell therapy for autoimmune and inflammatory disorders, as well as for other clinical conditions, due to their immunoregulatory and regenerative properties. MSCs modulate the inflammatory milieu by releasing soluble factors and acting through cell-to-cell mechanisms. MSCs switch the classical inflammatory status of monocytes and macrophages towards a non-classical and anti-inflammatory phenotype. This is characterized by an increased secretion of anti-inflammatory cytokines, a decreased release of pro-inflammatory cytokines, and changes in the expression of cell membrane molecules and in metabolic pathways. The MSC modulation of monocyte and macrophage phenotypes seems to be critical for therapy effectiveness in several disease models, since when these cells are depleted, no immunoregulatory effects are observed. Here, we review the effects of living MSCs (metabolically active cells) and metabolically inactive MSCs (dead cells that lost metabolic activity by induced inactivation) and their derivatives (extracellular vesicles, soluble factors, extracts, and microparticles) on the profile of macrophages and monocytes and the implications for immunoregulatory and reparative processes. This review includes mechanisms of action exhibited in these different therapeutic approaches, which induce the anti-inflammatory properties of monocytes and macrophages. Finally, we overview several possibilities of therapeutic applications of these cells and their derivatives, with results regarding monocytes and macrophages in animal model studies and some clinical trials.
id UFRGS-2_5811216c09dc9c2a14d9c3f313f4cae4
oai_identifier_str oai:www.lume.ufrgs.br:10183/233668
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Sant'Ana, Alexia NedelAraujo, Anelise BergmannGonçalves, Fabiany da CostaPaz, Ana Helena da Rosa2022-01-04T04:35:20Z20211948-0210http://hdl.handle.net/10183/233668001134507Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cells that have great potential as cell therapy for autoimmune and inflammatory disorders, as well as for other clinical conditions, due to their immunoregulatory and regenerative properties. MSCs modulate the inflammatory milieu by releasing soluble factors and acting through cell-to-cell mechanisms. MSCs switch the classical inflammatory status of monocytes and macrophages towards a non-classical and anti-inflammatory phenotype. This is characterized by an increased secretion of anti-inflammatory cytokines, a decreased release of pro-inflammatory cytokines, and changes in the expression of cell membrane molecules and in metabolic pathways. The MSC modulation of monocyte and macrophage phenotypes seems to be critical for therapy effectiveness in several disease models, since when these cells are depleted, no immunoregulatory effects are observed. Here, we review the effects of living MSCs (metabolically active cells) and metabolically inactive MSCs (dead cells that lost metabolic activity by induced inactivation) and their derivatives (extracellular vesicles, soluble factors, extracts, and microparticles) on the profile of macrophages and monocytes and the implications for immunoregulatory and reparative processes. This review includes mechanisms of action exhibited in these different therapeutic approaches, which induce the anti-inflammatory properties of monocytes and macrophages. Finally, we overview several possibilities of therapeutic applications of these cells and their derivatives, with results regarding monocytes and macrophages in animal model studies and some clinical trials.application/pdfengWorld journal of stem cells. Pleasanton. Vol. 13, no. 9 (Sept. 2021), p. 1160-1176Células-tronco mesenquimaisMonocitosMacrófagosImunomodulacaoMesenchymal stromal cellsMacrophageMonocyteImmunomodulationCell therapyImmunoregulationEffects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophagesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001134507.pdf.txt001134507.pdf.txtExtracted Texttext/plain83134http://www.lume.ufrgs.br/bitstream/10183/233668/2/001134507.pdf.txt841fdeaa377bafadcec55cd93b973fb9MD52ORIGINAL001134507.pdfTexto completo (inglês)application/pdf1273089http://www.lume.ufrgs.br/bitstream/10183/233668/1/001134507.pdfdfe246bfca132e2c20d6017d07da7579MD5110183/2336682022-02-22 05:11:38.549155oai:www.lume.ufrgs.br:10183/233668Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2022-02-22T08:11:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
title Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
spellingShingle Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
Sant'Ana, Alexia Nedel
Células-tronco mesenquimais
Monocitos
Macrófagos
Imunomodulacao
Mesenchymal stromal cells
Macrophage
Monocyte
Immunomodulation
Cell therapy
Immunoregulation
title_short Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
title_full Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
title_fullStr Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
title_full_unstemmed Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
title_sort Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
author Sant'Ana, Alexia Nedel
author_facet Sant'Ana, Alexia Nedel
Araujo, Anelise Bergmann
Gonçalves, Fabiany da Costa
Paz, Ana Helena da Rosa
author_role author
author2 Araujo, Anelise Bergmann
Gonçalves, Fabiany da Costa
Paz, Ana Helena da Rosa
author2_role author
author
author
dc.contributor.author.fl_str_mv Sant'Ana, Alexia Nedel
Araujo, Anelise Bergmann
Gonçalves, Fabiany da Costa
Paz, Ana Helena da Rosa
dc.subject.por.fl_str_mv Células-tronco mesenquimais
Monocitos
Macrófagos
Imunomodulacao
topic Células-tronco mesenquimais
Monocitos
Macrófagos
Imunomodulacao
Mesenchymal stromal cells
Macrophage
Monocyte
Immunomodulation
Cell therapy
Immunoregulation
dc.subject.eng.fl_str_mv Mesenchymal stromal cells
Macrophage
Monocyte
Immunomodulation
Cell therapy
Immunoregulation
description Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cells that have great potential as cell therapy for autoimmune and inflammatory disorders, as well as for other clinical conditions, due to their immunoregulatory and regenerative properties. MSCs modulate the inflammatory milieu by releasing soluble factors and acting through cell-to-cell mechanisms. MSCs switch the classical inflammatory status of monocytes and macrophages towards a non-classical and anti-inflammatory phenotype. This is characterized by an increased secretion of anti-inflammatory cytokines, a decreased release of pro-inflammatory cytokines, and changes in the expression of cell membrane molecules and in metabolic pathways. The MSC modulation of monocyte and macrophage phenotypes seems to be critical for therapy effectiveness in several disease models, since when these cells are depleted, no immunoregulatory effects are observed. Here, we review the effects of living MSCs (metabolically active cells) and metabolically inactive MSCs (dead cells that lost metabolic activity by induced inactivation) and their derivatives (extracellular vesicles, soluble factors, extracts, and microparticles) on the profile of macrophages and monocytes and the implications for immunoregulatory and reparative processes. This review includes mechanisms of action exhibited in these different therapeutic approaches, which induce the anti-inflammatory properties of monocytes and macrophages. Finally, we overview several possibilities of therapeutic applications of these cells and their derivatives, with results regarding monocytes and macrophages in animal model studies and some clinical trials.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-01-04T04:35:20Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/233668
dc.identifier.issn.pt_BR.fl_str_mv 1948-0210
dc.identifier.nrb.pt_BR.fl_str_mv 001134507
identifier_str_mv 1948-0210
001134507
url http://hdl.handle.net/10183/233668
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv World journal of stem cells. Pleasanton. Vol. 13, no. 9 (Sept. 2021), p. 1160-1176
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/233668/2/001134507.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/233668/1/001134507.pdf
bitstream.checksum.fl_str_mv 841fdeaa377bafadcec55cd93b973fb9
dfe246bfca132e2c20d6017d07da7579
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv lume@ufrgs.br
_version_ 1817725125438472192