Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/233668 |
Resumo: | Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cells that have great potential as cell therapy for autoimmune and inflammatory disorders, as well as for other clinical conditions, due to their immunoregulatory and regenerative properties. MSCs modulate the inflammatory milieu by releasing soluble factors and acting through cell-to-cell mechanisms. MSCs switch the classical inflammatory status of monocytes and macrophages towards a non-classical and anti-inflammatory phenotype. This is characterized by an increased secretion of anti-inflammatory cytokines, a decreased release of pro-inflammatory cytokines, and changes in the expression of cell membrane molecules and in metabolic pathways. The MSC modulation of monocyte and macrophage phenotypes seems to be critical for therapy effectiveness in several disease models, since when these cells are depleted, no immunoregulatory effects are observed. Here, we review the effects of living MSCs (metabolically active cells) and metabolically inactive MSCs (dead cells that lost metabolic activity by induced inactivation) and their derivatives (extracellular vesicles, soluble factors, extracts, and microparticles) on the profile of macrophages and monocytes and the implications for immunoregulatory and reparative processes. This review includes mechanisms of action exhibited in these different therapeutic approaches, which induce the anti-inflammatory properties of monocytes and macrophages. Finally, we overview several possibilities of therapeutic applications of these cells and their derivatives, with results regarding monocytes and macrophages in animal model studies and some clinical trials. |
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Sant'Ana, Alexia NedelAraujo, Anelise BergmannGonçalves, Fabiany da CostaPaz, Ana Helena da Rosa2022-01-04T04:35:20Z20211948-0210http://hdl.handle.net/10183/233668001134507Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cells that have great potential as cell therapy for autoimmune and inflammatory disorders, as well as for other clinical conditions, due to their immunoregulatory and regenerative properties. MSCs modulate the inflammatory milieu by releasing soluble factors and acting through cell-to-cell mechanisms. MSCs switch the classical inflammatory status of monocytes and macrophages towards a non-classical and anti-inflammatory phenotype. This is characterized by an increased secretion of anti-inflammatory cytokines, a decreased release of pro-inflammatory cytokines, and changes in the expression of cell membrane molecules and in metabolic pathways. The MSC modulation of monocyte and macrophage phenotypes seems to be critical for therapy effectiveness in several disease models, since when these cells are depleted, no immunoregulatory effects are observed. Here, we review the effects of living MSCs (metabolically active cells) and metabolically inactive MSCs (dead cells that lost metabolic activity by induced inactivation) and their derivatives (extracellular vesicles, soluble factors, extracts, and microparticles) on the profile of macrophages and monocytes and the implications for immunoregulatory and reparative processes. This review includes mechanisms of action exhibited in these different therapeutic approaches, which induce the anti-inflammatory properties of monocytes and macrophages. Finally, we overview several possibilities of therapeutic applications of these cells and their derivatives, with results regarding monocytes and macrophages in animal model studies and some clinical trials.application/pdfengWorld journal of stem cells. Pleasanton. Vol. 13, no. 9 (Sept. 2021), p. 1160-1176Células-tronco mesenquimaisMonocitosMacrófagosImunomodulacaoMesenchymal stromal cellsMacrophageMonocyteImmunomodulationCell therapyImmunoregulationEffects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophagesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001134507.pdf.txt001134507.pdf.txtExtracted Texttext/plain83134http://www.lume.ufrgs.br/bitstream/10183/233668/2/001134507.pdf.txt841fdeaa377bafadcec55cd93b973fb9MD52ORIGINAL001134507.pdfTexto completo (inglês)application/pdf1273089http://www.lume.ufrgs.br/bitstream/10183/233668/1/001134507.pdfdfe246bfca132e2c20d6017d07da7579MD5110183/2336682022-02-22 05:11:38.549155oai:www.lume.ufrgs.br:10183/233668Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2022-02-22T08:11:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages |
title |
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages |
spellingShingle |
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages Sant'Ana, Alexia Nedel Células-tronco mesenquimais Monocitos Macrófagos Imunomodulacao Mesenchymal stromal cells Macrophage Monocyte Immunomodulation Cell therapy Immunoregulation |
title_short |
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages |
title_full |
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages |
title_fullStr |
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages |
title_full_unstemmed |
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages |
title_sort |
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages |
author |
Sant'Ana, Alexia Nedel |
author_facet |
Sant'Ana, Alexia Nedel Araujo, Anelise Bergmann Gonçalves, Fabiany da Costa Paz, Ana Helena da Rosa |
author_role |
author |
author2 |
Araujo, Anelise Bergmann Gonçalves, Fabiany da Costa Paz, Ana Helena da Rosa |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Sant'Ana, Alexia Nedel Araujo, Anelise Bergmann Gonçalves, Fabiany da Costa Paz, Ana Helena da Rosa |
dc.subject.por.fl_str_mv |
Células-tronco mesenquimais Monocitos Macrófagos Imunomodulacao |
topic |
Células-tronco mesenquimais Monocitos Macrófagos Imunomodulacao Mesenchymal stromal cells Macrophage Monocyte Immunomodulation Cell therapy Immunoregulation |
dc.subject.eng.fl_str_mv |
Mesenchymal stromal cells Macrophage Monocyte Immunomodulation Cell therapy Immunoregulation |
description |
Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cells that have great potential as cell therapy for autoimmune and inflammatory disorders, as well as for other clinical conditions, due to their immunoregulatory and regenerative properties. MSCs modulate the inflammatory milieu by releasing soluble factors and acting through cell-to-cell mechanisms. MSCs switch the classical inflammatory status of monocytes and macrophages towards a non-classical and anti-inflammatory phenotype. This is characterized by an increased secretion of anti-inflammatory cytokines, a decreased release of pro-inflammatory cytokines, and changes in the expression of cell membrane molecules and in metabolic pathways. The MSC modulation of monocyte and macrophage phenotypes seems to be critical for therapy effectiveness in several disease models, since when these cells are depleted, no immunoregulatory effects are observed. Here, we review the effects of living MSCs (metabolically active cells) and metabolically inactive MSCs (dead cells that lost metabolic activity by induced inactivation) and their derivatives (extracellular vesicles, soluble factors, extracts, and microparticles) on the profile of macrophages and monocytes and the implications for immunoregulatory and reparative processes. This review includes mechanisms of action exhibited in these different therapeutic approaches, which induce the anti-inflammatory properties of monocytes and macrophages. Finally, we overview several possibilities of therapeutic applications of these cells and their derivatives, with results regarding monocytes and macrophages in animal model studies and some clinical trials. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-01-04T04:35:20Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/233668 |
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1948-0210 |
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001134507 |
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1948-0210 001134507 |
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http://hdl.handle.net/10183/233668 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
World journal of stem cells. Pleasanton. Vol. 13, no. 9 (Sept. 2021), p. 1160-1176 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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