Biological pathways associated with neuroprogression in bipolar disorder
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/243203 |
Resumo: | There is evidence suggesting clinical progression in a subset of patients with bipolar disorder (BD). This progression is associated with worse clinical outcomes and biological changes. Molecular pathways and biological markers of clinical progression have been identified and may explain the progressive changes associated with this disorder. The biological basis for clinical progression in BD is called neuroprogression. We propose that the following intertwined pathways provide the biological basis of neuroprogression: inflammation, oxidative stress, impaired calcium signaling, endoplasmic reticulum and mitochondrial dysfunction, and impaired neuroplasticity and cellular resilience. The nonlinear interaction of these pathways may worsen clinical outcomes, cognition, and functioning. Understanding neuroprogression in BD is crucial for identifying novel therapeutic targets, preventing illness progression, and ultimately promoting better outcomes. |
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Aguiar, Bianca Wollenhaupt deKapczinski, Flávio PereiraPfaffenseller, Bianca2022-07-20T04:49:11Z20212076-3425http://hdl.handle.net/10183/243203001145127There is evidence suggesting clinical progression in a subset of patients with bipolar disorder (BD). This progression is associated with worse clinical outcomes and biological changes. Molecular pathways and biological markers of clinical progression have been identified and may explain the progressive changes associated with this disorder. The biological basis for clinical progression in BD is called neuroprogression. We propose that the following intertwined pathways provide the biological basis of neuroprogression: inflammation, oxidative stress, impaired calcium signaling, endoplasmic reticulum and mitochondrial dysfunction, and impaired neuroplasticity and cellular resilience. The nonlinear interaction of these pathways may worsen clinical outcomes, cognition, and functioning. Understanding neuroprogression in BD is crucial for identifying novel therapeutic targets, preventing illness progression, and ultimately promoting better outcomes.application/pdfengBrain sciences. Basel. Vol. 11, no. 2 (2021), 228, 12 p.BiomarcadoresTranstorno bipolarProgressão da doençaBiomarkersBipolar disorderIllness progressionNeuroprogressionBiological pathways associated with neuroprogression in bipolar disorderEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001145127.pdf.txt001145127.pdf.txtExtracted Texttext/plain52041http://www.lume.ufrgs.br/bitstream/10183/243203/2/001145127.pdf.txt4fa974a685fb7affdece061628555a2fMD52ORIGINAL001145127.pdfTexto completo (inglês)application/pdf10143531http://www.lume.ufrgs.br/bitstream/10183/243203/1/001145127.pdf3ad373331bef99909d9c30da7426bff4MD5110183/2432032022-07-21 04:55:03.732341oai:www.lume.ufrgs.br:10183/243203Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-07-21T07:55:03Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Biological pathways associated with neuroprogression in bipolar disorder |
title |
Biological pathways associated with neuroprogression in bipolar disorder |
spellingShingle |
Biological pathways associated with neuroprogression in bipolar disorder Aguiar, Bianca Wollenhaupt de Biomarcadores Transtorno bipolar Progressão da doença Biomarkers Bipolar disorder Illness progression Neuroprogression |
title_short |
Biological pathways associated with neuroprogression in bipolar disorder |
title_full |
Biological pathways associated with neuroprogression in bipolar disorder |
title_fullStr |
Biological pathways associated with neuroprogression in bipolar disorder |
title_full_unstemmed |
Biological pathways associated with neuroprogression in bipolar disorder |
title_sort |
Biological pathways associated with neuroprogression in bipolar disorder |
author |
Aguiar, Bianca Wollenhaupt de |
author_facet |
Aguiar, Bianca Wollenhaupt de Kapczinski, Flávio Pereira Pfaffenseller, Bianca |
author_role |
author |
author2 |
Kapczinski, Flávio Pereira Pfaffenseller, Bianca |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Aguiar, Bianca Wollenhaupt de Kapczinski, Flávio Pereira Pfaffenseller, Bianca |
dc.subject.por.fl_str_mv |
Biomarcadores Transtorno bipolar Progressão da doença |
topic |
Biomarcadores Transtorno bipolar Progressão da doença Biomarkers Bipolar disorder Illness progression Neuroprogression |
dc.subject.eng.fl_str_mv |
Biomarkers Bipolar disorder Illness progression Neuroprogression |
description |
There is evidence suggesting clinical progression in a subset of patients with bipolar disorder (BD). This progression is associated with worse clinical outcomes and biological changes. Molecular pathways and biological markers of clinical progression have been identified and may explain the progressive changes associated with this disorder. The biological basis for clinical progression in BD is called neuroprogression. We propose that the following intertwined pathways provide the biological basis of neuroprogression: inflammation, oxidative stress, impaired calcium signaling, endoplasmic reticulum and mitochondrial dysfunction, and impaired neuroplasticity and cellular resilience. The nonlinear interaction of these pathways may worsen clinical outcomes, cognition, and functioning. Understanding neuroprogression in BD is crucial for identifying novel therapeutic targets, preventing illness progression, and ultimately promoting better outcomes. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-07-20T04:49:11Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/243203 |
dc.identifier.issn.pt_BR.fl_str_mv |
2076-3425 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001145127 |
identifier_str_mv |
2076-3425 001145127 |
url |
http://hdl.handle.net/10183/243203 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brain sciences. Basel. Vol. 11, no. 2 (2021), 228, 12 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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UFRGS |
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UFRGS |
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Repositório Institucional da UFRGS |
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Repositório Institucional da UFRGS |
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