Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/234265 |
Resumo: | It has previously been found a potent 2,3,4-oxazolidine series which was synthetized using the amino acid D-serine as the starting material. These compounds were assayed against cancer cell lines (HL60, JURKAT, LNCaP, MDA-MB-231, MCF-7, HCT-116) and their structure−activity relationship were investigated. The purpose of this work was to synthetize through seven steps, characterize and evaluate four 2,3,4-oxazolidines analogues against DAOY, SK-N-BE(2) and RD-ES pediatric cell lines. Compounds 5a and 5b designed by the extension of the structure of 1 were the most potent, being active against all cell lines (IC50 ≤ 7 μM) and reduced ≥ 90% of cell viability at 25 μM for RD-ES and SK-N-BE(2). These derivatives were identified as novel anticancer agents including the novel direction towards pediatric cancer cells. |
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Fortes, Isadora SerraglioAndrade, Saulo Fernandes deRocha, Débora Assumpção2022-01-20T04:38:29Z2018http://hdl.handle.net/10183/234265001094673It has previously been found a potent 2,3,4-oxazolidine series which was synthetized using the amino acid D-serine as the starting material. These compounds were assayed against cancer cell lines (HL60, JURKAT, LNCaP, MDA-MB-231, MCF-7, HCT-116) and their structure−activity relationship were investigated. The purpose of this work was to synthetize through seven steps, characterize and evaluate four 2,3,4-oxazolidines analogues against DAOY, SK-N-BE(2) and RD-ES pediatric cell lines. Compounds 5a and 5b designed by the extension of the structure of 1 were the most potent, being active against all cell lines (IC50 ≤ 7 μM) and reduced ≥ 90% of cell viability at 25 μM for RD-ES and SK-N-BE(2). These derivatives were identified as novel anticancer agents including the novel direction towards pediatric cancer cells.application/pdfengCâncerOxazolidinonasPediatric cancerAnti-cancerSynthesisOxazolidinesChiralSynthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUniversidade Federal do Rio Grande do SulFaculdade de FarmáciaPorto Alegre, BR-RS2018Farmáciagraduaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001094673.pdf.txt001094673.pdf.txtExtracted Texttext/plain84255http://www.lume.ufrgs.br/bitstream/10183/234265/2/001094673.pdf.txt50159ac7a5b0e1b1d24b2730f4edfd91MD52ORIGINAL001094673.pdfTexto completoapplication/pdf1342300http://www.lume.ufrgs.br/bitstream/10183/234265/1/001094673.pdfe524625980c10373a216869835ca8674MD5110183/2342652022-02-22 04:45:36.300181oai:www.lume.ufrgs.br:10183/234265Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-02-22T07:45:36Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells |
title |
Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells |
spellingShingle |
Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells Fortes, Isadora Serraglio Câncer Oxazolidinonas Pediatric cancer Anti-cancer Synthesis Oxazolidines Chiral |
title_short |
Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells |
title_full |
Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells |
title_fullStr |
Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells |
title_full_unstemmed |
Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells |
title_sort |
Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells |
author |
Fortes, Isadora Serraglio |
author_facet |
Fortes, Isadora Serraglio |
author_role |
author |
dc.contributor.author.fl_str_mv |
Fortes, Isadora Serraglio |
dc.contributor.advisor1.fl_str_mv |
Andrade, Saulo Fernandes de |
dc.contributor.advisor-co1.fl_str_mv |
Rocha, Débora Assumpção |
contributor_str_mv |
Andrade, Saulo Fernandes de Rocha, Débora Assumpção |
dc.subject.por.fl_str_mv |
Câncer Oxazolidinonas |
topic |
Câncer Oxazolidinonas Pediatric cancer Anti-cancer Synthesis Oxazolidines Chiral |
dc.subject.eng.fl_str_mv |
Pediatric cancer Anti-cancer Synthesis Oxazolidines Chiral |
description |
It has previously been found a potent 2,3,4-oxazolidine series which was synthetized using the amino acid D-serine as the starting material. These compounds were assayed against cancer cell lines (HL60, JURKAT, LNCaP, MDA-MB-231, MCF-7, HCT-116) and their structure−activity relationship were investigated. The purpose of this work was to synthetize through seven steps, characterize and evaluate four 2,3,4-oxazolidines analogues against DAOY, SK-N-BE(2) and RD-ES pediatric cell lines. Compounds 5a and 5b designed by the extension of the structure of 1 were the most potent, being active against all cell lines (IC50 ≤ 7 μM) and reduced ≥ 90% of cell viability at 25 μM for RD-ES and SK-N-BE(2). These derivatives were identified as novel anticancer agents including the novel direction towards pediatric cancer cells. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2022-01-20T04:38:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/234265 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001094673 |
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http://hdl.handle.net/10183/234265 |
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001094673 |
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eng |
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openAccess |
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Repositório Institucional da UFRGS |
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