Neurodevelopment in children exposed to Zika in utero : clinical and molecular aspects

• Autor(a) principal: Faccini, Lavinia Schuler
• Data de Publicação: 2022
• Outros Autores: Boquett, Juliano André, Kowalski, Thayne Woycinck, Gerzson, Laís Rodrigues, Almeida, Carla Skilhan de, Santi, Lucélia, Silva, Walter Orlando Beys da, Quincozes-Santos, André, Gomes, Julia do Amaral, Vianna, Fernanda Sales Luiz, Fraga, Lucas Rosa, Rosa, Rafael Lopes da, Abeche, Alberto Mantovani, Souza, Diogo Onofre Gomes de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/239804
• topic: Infecção por Zika virus; Manifestações neurológicas; Transtornos do neurodesenvolvimento; Criança; Deficiências do desenvolvimento; Microcephaly; Zika (ZIKV); Epilepsy; Cerebral palsy; Neurodevelopement; Eye

Five years after the identification of Zika virus as a human teratogen, we reviewed the early clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with CZS have a very poor prognosis with extremely low performance in motor, cognitive, and language development domains, and practically all feature severe forms of cerebral palsy. However, these manifestations are the tip of the iceberg, with some children presenting milder forms of deficits. Additionally, neurodevelopment can be in the normal range in the majority of the non-microcephalic children born without brain or eye abnormalities. Vertical transmission and the resulting disruption in development of the brain are much less frequent when maternal infection occurs in the second half of the pregnancy. Experimental studies have alerted to the possibility of other behavioral outcomes both in prenatally infected children and in postnatal and adult infections. Cofactors play a vital role in the development of CZS and involve genetic, environmental, nutritional, and social determinants leading to the asymmetric distribution of cases. Some of these social variables also limit access to multidisciplinary professional treatment.