Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/196841 |
Resumo: | Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes (T1DM). Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes, a cause-effect relationship is less clear in T1DM. Although endothelial dysfunction (ED) precedes atherosclerosis, it is not clear weather, in recent onset T1DM, it may progress to clinical macrovascular disease. Moreover, endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control, long-term exercise training and use of statins. Acute, long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1DM. The pathogenesis of endothelial dysfunction is closely related to oxidative-stress. NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells, thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation, a potent oxidant agent. Moreover, oxidative stress also uncouples endothelial nitric oxide synthase, which becomes dysfunctional, inducing formation of superoxide. Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products. Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1DM. |
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Boff, WinstonWainstein, Marco VugmanPuñales, Márcia KhaledSilva, Antônio Marcos Vargas daCé, Gislaine VissokyBertoluci, Marcello Casaccia2019-07-12T02:36:09Z20151948-9358http://hdl.handle.net/10183/196841000989727Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes (T1DM). Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes, a cause-effect relationship is less clear in T1DM. Although endothelial dysfunction (ED) precedes atherosclerosis, it is not clear weather, in recent onset T1DM, it may progress to clinical macrovascular disease. Moreover, endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control, long-term exercise training and use of statins. Acute, long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1DM. The pathogenesis of endothelial dysfunction is closely related to oxidative-stress. NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells, thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation, a potent oxidant agent. Moreover, oxidative stress also uncouples endothelial nitric oxide synthase, which becomes dysfunctional, inducing formation of superoxide. Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products. Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1DM.application/pdfengWorld Journal of Diabetes. Pleasanton, CA. Vol. 6, n. 5 (Jun. 2015), p. 679-692Diabetes mellitus tipo 1Doenças cardiovascularesEndothelial dysfunctionType 1 diabetesCardiovascular diseaseEndothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000989727.pdf.txt000989727.pdf.txtExtracted Texttext/plain81023http://www.lume.ufrgs.br/bitstream/10183/196841/2/000989727.pdf.txtdc05c520d390c8aadaff8d3e1781dcb8MD52ORIGINAL000989727.pdfTexto completo (inglês)application/pdf1005118http://www.lume.ufrgs.br/bitstream/10183/196841/1/000989727.pdfa1ded153b1bae564f6336ce988b64c80MD5110183/1968412019-07-13 02:35:55.417678oai:www.lume.ufrgs.br:10183/196841Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-07-13T05:35:55Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes |
title |
Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes |
spellingShingle |
Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes Boff, Winston Diabetes mellitus tipo 1 Doenças cardiovasculares Endothelial dysfunction Type 1 diabetes Cardiovascular disease |
title_short |
Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes |
title_full |
Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes |
title_fullStr |
Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes |
title_full_unstemmed |
Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes |
title_sort |
Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes |
author |
Boff, Winston |
author_facet |
Boff, Winston Wainstein, Marco Vugman Puñales, Márcia Khaled Silva, Antônio Marcos Vargas da Cé, Gislaine Vissoky Bertoluci, Marcello Casaccia |
author_role |
author |
author2 |
Wainstein, Marco Vugman Puñales, Márcia Khaled Silva, Antônio Marcos Vargas da Cé, Gislaine Vissoky Bertoluci, Marcello Casaccia |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Boff, Winston Wainstein, Marco Vugman Puñales, Márcia Khaled Silva, Antônio Marcos Vargas da Cé, Gislaine Vissoky Bertoluci, Marcello Casaccia |
dc.subject.por.fl_str_mv |
Diabetes mellitus tipo 1 Doenças cardiovasculares |
topic |
Diabetes mellitus tipo 1 Doenças cardiovasculares Endothelial dysfunction Type 1 diabetes Cardiovascular disease |
dc.subject.eng.fl_str_mv |
Endothelial dysfunction Type 1 diabetes Cardiovascular disease |
description |
Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes (T1DM). Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes, a cause-effect relationship is less clear in T1DM. Although endothelial dysfunction (ED) precedes atherosclerosis, it is not clear weather, in recent onset T1DM, it may progress to clinical macrovascular disease. Moreover, endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control, long-term exercise training and use of statins. Acute, long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1DM. The pathogenesis of endothelial dysfunction is closely related to oxidative-stress. NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells, thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation, a potent oxidant agent. Moreover, oxidative stress also uncouples endothelial nitric oxide synthase, which becomes dysfunctional, inducing formation of superoxide. Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products. Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1DM. |
publishDate |
2015 |
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2015 |
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2019-07-12T02:36:09Z |
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World Journal of Diabetes. Pleasanton, CA. Vol. 6, n. 5 (Jun. 2015), p. 679-692 |
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