Peripheral inflammatory markers contributing to comorbidities in autism
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/175110 |
Resumo: | This study evaluates the contribution of peripheral biomarkers to comorbidities and clinical findings in autism. Seventeen autistic children and age-matched typically developing (AMTD), between three to nine years old were evaluated. The diagnostic followed the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DMS-IV) and the Childhood Autism Rating Scale (CARS) was applied to classify the severity. Cytokine profile was evaluated in plasma using a sandwich type ELISA. Paraclinical events included electroencephalography (EEG) record. Statistical analysis was done to explore significant differences in cytokine profile between autism and AMTD groups and respect clinical and paraclinical parameters. Significant differences were found to IL-1 , IL-6, IL-17, IL-12p40, and IL-12p70 cytokines in individuals with autism compared with AMTD (p < 0.05). All autistic patients showed interictalepileptiform activity at EEG, however, only 37.5% suffered epilepsy. There was not a regional focalization of the abnormalities that were detectable with EEG in autistic patients with history of epilepsy. A higher IL-6 level was observed in patients without history of epilepsy with interictalepileptiform activity in the frontal brain region, p < 0.05. In conclusion, peripheral inflammatory markers might be useful as potential biomarkers to predict comorbidities in autism as well as reinforce and aid informed decision-making related to EEG findings in children with Autism spectrum disorders (ASD). |
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Jácome, Martha Cecilia IngaChacòn, Lilia Maria MoralesCuesta, Hector VeraRizo, Carlos MaragotoSantiesteban, Mabel WhilbyHernandez, Lesyanis RamosGarcía, Elena NorisFraguela, Maria Elena GonzálezVerdecia, Caridad Ivette FernandezHurtado, Yamilé VegasSiniscalco, DarioGoncalves, Carlos Alberto SaraivaRobinson Agramonte, María de los Ángeles2018-04-26T02:33:51Z20162076-328Xhttp://hdl.handle.net/10183/175110001065847This study evaluates the contribution of peripheral biomarkers to comorbidities and clinical findings in autism. Seventeen autistic children and age-matched typically developing (AMTD), between three to nine years old were evaluated. The diagnostic followed the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DMS-IV) and the Childhood Autism Rating Scale (CARS) was applied to classify the severity. Cytokine profile was evaluated in plasma using a sandwich type ELISA. Paraclinical events included electroencephalography (EEG) record. Statistical analysis was done to explore significant differences in cytokine profile between autism and AMTD groups and respect clinical and paraclinical parameters. Significant differences were found to IL-1 , IL-6, IL-17, IL-12p40, and IL-12p70 cytokines in individuals with autism compared with AMTD (p < 0.05). All autistic patients showed interictalepileptiform activity at EEG, however, only 37.5% suffered epilepsy. There was not a regional focalization of the abnormalities that were detectable with EEG in autistic patients with history of epilepsy. A higher IL-6 level was observed in patients without history of epilepsy with interictalepileptiform activity in the frontal brain region, p < 0.05. In conclusion, peripheral inflammatory markers might be useful as potential biomarkers to predict comorbidities in autism as well as reinforce and aid informed decision-making related to EEG findings in children with Autism spectrum disorders (ASD).application/pdfengBehavioral sciences. Basel. Vol. 6 (Dec. 2016), 29, [14 p.]BiomarcadoresTranstorno do espectro autistaCitocinasEncefaliteEletroencefalografiaAutism spectrum disordersComorbiditiesEEGBehaviorEpilepsyNeuro-inflammationSocial interactionPeripheral inflammatory markers contributing to comorbidities in autismEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001065847.pdf001065847.pdfTexto completo (inglês)application/pdf1974062http://www.lume.ufrgs.br/bitstream/10183/175110/1/001065847.pdf312dd379b03fc9ad11933610071ed5d5MD51TEXT001065847.pdf.txt001065847.pdf.txtExtracted Texttext/plain51822http://www.lume.ufrgs.br/bitstream/10183/175110/2/001065847.pdf.txt22dd0043560169023f38707182db01d6MD52THUMBNAIL001065847.pdf.jpg001065847.pdf.jpgGenerated Thumbnailimage/jpeg1816http://www.lume.ufrgs.br/bitstream/10183/175110/3/001065847.pdf.jpg96f8e093da5d92449f982ca8b325a42dMD5310183/1751102018-10-25 09:54:05.359oai:www.lume.ufrgs.br:10183/175110Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-25T12:54:05Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Peripheral inflammatory markers contributing to comorbidities in autism |
title |
Peripheral inflammatory markers contributing to comorbidities in autism |
spellingShingle |
Peripheral inflammatory markers contributing to comorbidities in autism Jácome, Martha Cecilia Inga Biomarcadores Transtorno do espectro autista Citocinas Encefalite Eletroencefalografia Autism spectrum disorders Comorbidities EEG Behavior Epilepsy Neuro-inflammation Social interaction |
title_short |
Peripheral inflammatory markers contributing to comorbidities in autism |
title_full |
Peripheral inflammatory markers contributing to comorbidities in autism |
title_fullStr |
Peripheral inflammatory markers contributing to comorbidities in autism |
title_full_unstemmed |
Peripheral inflammatory markers contributing to comorbidities in autism |
title_sort |
Peripheral inflammatory markers contributing to comorbidities in autism |
author |
Jácome, Martha Cecilia Inga |
author_facet |
Jácome, Martha Cecilia Inga Chacòn, Lilia Maria Morales Cuesta, Hector Vera Rizo, Carlos Maragoto Santiesteban, Mabel Whilby Hernandez, Lesyanis Ramos García, Elena Noris Fraguela, Maria Elena González Verdecia, Caridad Ivette Fernandez Hurtado, Yamilé Vegas Siniscalco, Dario Goncalves, Carlos Alberto Saraiva Robinson Agramonte, María de los Ángeles |
author_role |
author |
author2 |
Chacòn, Lilia Maria Morales Cuesta, Hector Vera Rizo, Carlos Maragoto Santiesteban, Mabel Whilby Hernandez, Lesyanis Ramos García, Elena Noris Fraguela, Maria Elena González Verdecia, Caridad Ivette Fernandez Hurtado, Yamilé Vegas Siniscalco, Dario Goncalves, Carlos Alberto Saraiva Robinson Agramonte, María de los Ángeles |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Jácome, Martha Cecilia Inga Chacòn, Lilia Maria Morales Cuesta, Hector Vera Rizo, Carlos Maragoto Santiesteban, Mabel Whilby Hernandez, Lesyanis Ramos García, Elena Noris Fraguela, Maria Elena González Verdecia, Caridad Ivette Fernandez Hurtado, Yamilé Vegas Siniscalco, Dario Goncalves, Carlos Alberto Saraiva Robinson Agramonte, María de los Ángeles |
dc.subject.por.fl_str_mv |
Biomarcadores Transtorno do espectro autista Citocinas Encefalite Eletroencefalografia |
topic |
Biomarcadores Transtorno do espectro autista Citocinas Encefalite Eletroencefalografia Autism spectrum disorders Comorbidities EEG Behavior Epilepsy Neuro-inflammation Social interaction |
dc.subject.eng.fl_str_mv |
Autism spectrum disorders Comorbidities EEG Behavior Epilepsy Neuro-inflammation Social interaction |
description |
This study evaluates the contribution of peripheral biomarkers to comorbidities and clinical findings in autism. Seventeen autistic children and age-matched typically developing (AMTD), between three to nine years old were evaluated. The diagnostic followed the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DMS-IV) and the Childhood Autism Rating Scale (CARS) was applied to classify the severity. Cytokine profile was evaluated in plasma using a sandwich type ELISA. Paraclinical events included electroencephalography (EEG) record. Statistical analysis was done to explore significant differences in cytokine profile between autism and AMTD groups and respect clinical and paraclinical parameters. Significant differences were found to IL-1 , IL-6, IL-17, IL-12p40, and IL-12p70 cytokines in individuals with autism compared with AMTD (p < 0.05). All autistic patients showed interictalepileptiform activity at EEG, however, only 37.5% suffered epilepsy. There was not a regional focalization of the abnormalities that were detectable with EEG in autistic patients with history of epilepsy. A higher IL-6 level was observed in patients without history of epilepsy with interictalepileptiform activity in the frontal brain region, p < 0.05. In conclusion, peripheral inflammatory markers might be useful as potential biomarkers to predict comorbidities in autism as well as reinforce and aid informed decision-making related to EEG findings in children with Autism spectrum disorders (ASD). |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2018-04-26T02:33:51Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/175110 |
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2076-328X |
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001065847 |
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http://hdl.handle.net/10183/175110 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Behavioral sciences. Basel. Vol. 6 (Dec. 2016), 29, [14 p.] |
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openAccess |
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