Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/225574 |
Resumo: | Memories can be destabilized by the reexposure to the training context, and may reconsolidate into a modified engram. Reconsolidation relies on some particular molecular mechanisms involving LVGCCs and GluN2B-containing NMDARs. In this study we investigate the interference caused by the presence of a distractor - a brief, unanticipated stimulus that impair a fear memory expression - during the reactivation session, and tested the hypothesis that this disruptive effect relies on a reconsolidation process. Rats previously trained in the contextual fear conditioning (CFC) were reactivated in the presence or absence of a distractor stimulus. In the test, groups reactivated in the original context with distractor displayed a reduction of the freezing response lasting up to 20 days. To check for the involvement of destabilization / reconsolidation mechanisms, we studied the effect of systemic nimodipine (a L-VGCC blocker) or intra-CA1 ifenprodil (a selective GluN2B/NMDAR antagonist) infused right before the reactivation session. Both treatments were able to prevent the disruptive effect of distraction. Ifenprodil results also bolstered the case for hippocampus as the putative brain structure hosting this phenomenon. Our results provide some evidence in support of a behavioral, non-invasive procedure that was able to disrupt an aversive memory in a long-lasting way. |
id |
UFRGS-2_93d4fe2b36b46b6df2f7fe39b3f6df19 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/225574 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Crestani, Ana PaulaBoos, Flávia ZacouteguyHaubrich, JosuéOrdoñez Sierra, RodrigoSantana, FabianaMolina, Johanna Marcela DuranCassini, Lindsey FreitasAlvares, Lucas de OliveiraQuillfeldt, Jorge Alberto2021-08-12T04:43:43Z20152045-2322http://hdl.handle.net/10183/225574000977397Memories can be destabilized by the reexposure to the training context, and may reconsolidate into a modified engram. Reconsolidation relies on some particular molecular mechanisms involving LVGCCs and GluN2B-containing NMDARs. In this study we investigate the interference caused by the presence of a distractor - a brief, unanticipated stimulus that impair a fear memory expression - during the reactivation session, and tested the hypothesis that this disruptive effect relies on a reconsolidation process. Rats previously trained in the contextual fear conditioning (CFC) were reactivated in the presence or absence of a distractor stimulus. In the test, groups reactivated in the original context with distractor displayed a reduction of the freezing response lasting up to 20 days. To check for the involvement of destabilization / reconsolidation mechanisms, we studied the effect of systemic nimodipine (a L-VGCC blocker) or intra-CA1 ifenprodil (a selective GluN2B/NMDAR antagonist) infused right before the reactivation session. Both treatments were able to prevent the disruptive effect of distraction. Ifenprodil results also bolstered the case for hippocampus as the putative brain structure hosting this phenomenon. Our results provide some evidence in support of a behavioral, non-invasive procedure that was able to disrupt an aversive memory in a long-lasting way.application/pdfengScientific reports. London. Vol. 5, (2015), 13633, 1-9 p.MemóriaMemory reconsolidation may be disrupted by a distractor stimulus presented during reactivationEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000977397.pdf.txt000977397.pdf.txtExtracted Texttext/plain38098http://www.lume.ufrgs.br/bitstream/10183/225574/2/000977397.pdf.txt25a61071a38f2af1d671050fa59017c9MD52ORIGINAL000977397.pdfTexto completo (inglês)application/pdf715021http://www.lume.ufrgs.br/bitstream/10183/225574/1/000977397.pdf0e88bad400a52a95286c3ac9869a1e75MD5110183/2255742021-08-18 04:37:30.15487oai:www.lume.ufrgs.br:10183/225574Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-08-18T07:37:30Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation |
title |
Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation |
spellingShingle |
Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation Crestani, Ana Paula Memória |
title_short |
Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation |
title_full |
Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation |
title_fullStr |
Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation |
title_full_unstemmed |
Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation |
title_sort |
Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation |
author |
Crestani, Ana Paula |
author_facet |
Crestani, Ana Paula Boos, Flávia Zacouteguy Haubrich, Josué Ordoñez Sierra, Rodrigo Santana, Fabiana Molina, Johanna Marcela Duran Cassini, Lindsey Freitas Alvares, Lucas de Oliveira Quillfeldt, Jorge Alberto |
author_role |
author |
author2 |
Boos, Flávia Zacouteguy Haubrich, Josué Ordoñez Sierra, Rodrigo Santana, Fabiana Molina, Johanna Marcela Duran Cassini, Lindsey Freitas Alvares, Lucas de Oliveira Quillfeldt, Jorge Alberto |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Crestani, Ana Paula Boos, Flávia Zacouteguy Haubrich, Josué Ordoñez Sierra, Rodrigo Santana, Fabiana Molina, Johanna Marcela Duran Cassini, Lindsey Freitas Alvares, Lucas de Oliveira Quillfeldt, Jorge Alberto |
dc.subject.por.fl_str_mv |
Memória |
topic |
Memória |
description |
Memories can be destabilized by the reexposure to the training context, and may reconsolidate into a modified engram. Reconsolidation relies on some particular molecular mechanisms involving LVGCCs and GluN2B-containing NMDARs. In this study we investigate the interference caused by the presence of a distractor - a brief, unanticipated stimulus that impair a fear memory expression - during the reactivation session, and tested the hypothesis that this disruptive effect relies on a reconsolidation process. Rats previously trained in the contextual fear conditioning (CFC) were reactivated in the presence or absence of a distractor stimulus. In the test, groups reactivated in the original context with distractor displayed a reduction of the freezing response lasting up to 20 days. To check for the involvement of destabilization / reconsolidation mechanisms, we studied the effect of systemic nimodipine (a L-VGCC blocker) or intra-CA1 ifenprodil (a selective GluN2B/NMDAR antagonist) infused right before the reactivation session. Both treatments were able to prevent the disruptive effect of distraction. Ifenprodil results also bolstered the case for hippocampus as the putative brain structure hosting this phenomenon. Our results provide some evidence in support of a behavioral, non-invasive procedure that was able to disrupt an aversive memory in a long-lasting way. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2021-08-12T04:43:43Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/225574 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000977397 |
identifier_str_mv |
2045-2322 000977397 |
url |
http://hdl.handle.net/10183/225574 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Scientific reports. London. Vol. 5, (2015), 13633, 1-9 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/225574/2/000977397.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/225574/1/000977397.pdf |
bitstream.checksum.fl_str_mv |
25a61071a38f2af1d671050fa59017c9 0e88bad400a52a95286c3ac9869a1e75 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801225032149499904 |