Inclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activity
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/212564 |
Resumo: | α, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD's as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM. |
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Silva Júnior, Walter Ferreira daMenezes, Danielle Lima Bezerra deOliveira, Luana Carvalho deKoester, Leticia SchererAlmeida, Patrícia Danielle Oliveira deLima, Emerson SilvaAzevedo, Eduardo Pereira deVeiga Junior, Valdir Florencio daLima, Adley Antonini Neves de2020-08-04T03:38:31Z20192218-273Xhttp://hdl.handle.net/10183/212564001115566α, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD's as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM.application/pdfengBiomolecules. Basel. Vol. 9, no. 6 (2019), 241, [14 p.]FarmáciaCiclodextrinasAnti-inflamatóriosAmyrinCyclodextrinInclusion complexesAnti-inflammatoryInclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activityEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001115566.pdf.txt001115566.pdf.txtExtracted Texttext/plain59778http://www.lume.ufrgs.br/bitstream/10183/212564/2/001115566.pdf.txt07115733743184fbe7db98dbbba73e37MD52ORIGINAL001115566.pdfTexto completo (inglês)application/pdf2086657http://www.lume.ufrgs.br/bitstream/10183/212564/1/001115566.pdf33c8195a343a242d95c4f1dc6d2610ddMD5110183/2125642023-08-09 03:47:34.177652oai:www.lume.ufrgs.br:10183/212564Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-09T06:47:34Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Inclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activity |
title |
Inclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activity |
spellingShingle |
Inclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activity Silva Júnior, Walter Ferreira da Farmácia Ciclodextrinas Anti-inflamatórios Amyrin Cyclodextrin Inclusion complexes Anti-inflammatory |
title_short |
Inclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activity |
title_full |
Inclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activity |
title_fullStr |
Inclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activity |
title_full_unstemmed |
Inclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activity |
title_sort |
Inclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activity |
author |
Silva Júnior, Walter Ferreira da |
author_facet |
Silva Júnior, Walter Ferreira da Menezes, Danielle Lima Bezerra de Oliveira, Luana Carvalho de Koester, Leticia Scherer Almeida, Patrícia Danielle Oliveira de Lima, Emerson Silva Azevedo, Eduardo Pereira de Veiga Junior, Valdir Florencio da Lima, Adley Antonini Neves de |
author_role |
author |
author2 |
Menezes, Danielle Lima Bezerra de Oliveira, Luana Carvalho de Koester, Leticia Scherer Almeida, Patrícia Danielle Oliveira de Lima, Emerson Silva Azevedo, Eduardo Pereira de Veiga Junior, Valdir Florencio da Lima, Adley Antonini Neves de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva Júnior, Walter Ferreira da Menezes, Danielle Lima Bezerra de Oliveira, Luana Carvalho de Koester, Leticia Scherer Almeida, Patrícia Danielle Oliveira de Lima, Emerson Silva Azevedo, Eduardo Pereira de Veiga Junior, Valdir Florencio da Lima, Adley Antonini Neves de |
dc.subject.por.fl_str_mv |
Farmácia Ciclodextrinas Anti-inflamatórios |
topic |
Farmácia Ciclodextrinas Anti-inflamatórios Amyrin Cyclodextrin Inclusion complexes Anti-inflammatory |
dc.subject.eng.fl_str_mv |
Amyrin Cyclodextrin Inclusion complexes Anti-inflammatory |
description |
α, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD's as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2020-08-04T03:38:31Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/212564 |
dc.identifier.issn.pt_BR.fl_str_mv |
2218-273X |
dc.identifier.nrb.pt_BR.fl_str_mv |
001115566 |
identifier_str_mv |
2218-273X 001115566 |
url |
http://hdl.handle.net/10183/212564 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Biomolecules. Basel. Vol. 9, no. 6 (2019), 241, [14 p.] |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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