Neonatal liver failure and congenital cirrhosis due to gestational alloimmune liver disease : a case report and literature review

• Autor(a) principal: Rocha, Carolina Roos Mariano da
• Data de Publicação: 2017
• Outros Autores: Guedes, Renata Rostirola, Kieling, Carlos Oscar, Adami, Marina Rossato, Cerski, Carlos Thadeu Schmidt, Vieira, Sandra Maria Gonçalves
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/180266
• topic: Falência hepática; Recém-nascido; Hemocromatose

Neonatal liver failure (NLF) is amajor cause of neonatalmorbidity andmortality, presenting as acute liver failure and/or congenital cirrhosis. Many affected patients show antenatal signs of fetal injury. There are several causes of NLF and early diagnosis is mandatory to elucidate the etiology and determine a specific treatment or the best management strategy. Gestational alloimmune liver disease associated with neonatal hemochromatosis (GALD-NH) is a rare but potentially treatable cause of NLF. It should be considered in any neonate with fetal signs of disease and postnatal signs of liver failure with no other identifiable causes. GALD-NH is often diagnosed late and patients are therefore referred late to specialized centers, delaying treatment. This case highlights the consequences of late diagnosis and treatment of GALD-NH and emphasizes the importance of a high grade of suspicion of this disease in order to refer the patient to a specialized center soon enough to perform the appropriate treatment.