Divergent action of fluoxetine in zebrafish according to responsivity to novelty
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/197550 |
Resumo: | Here we show that the novel object recognition test can discriminate between high (HRN, neophobic) and low (LRN, neophilic) novelty responders in zebrafish populations. Especially when we observe the latency to the first entry in the novel object zone, zebrafish did not maintain these behavioral phenotypes in sequential tests and only the HRN group returned to their initial responsive behavior when exposed to fluoxetine. Our results have important implications for behavioral data analysis since such behavioral differences can potentially increase individual response variability and interfere with the outcomes obtained from various behavioral tasks. Our data reinforce the validity of personality determination in zebrafish since we show clear differences in behavior in response to fluoxetine. |
id |
UFRGS-2_c153914be2c9e0ffae1722c3f0224819 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/197550 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Fior, DéboraDametto, Fernanda da SilveiraFagundes, MicheleRosa, João Gabriel SantosAbreu, Murilo Sander deKoakoski, GessiIdalencio, RenanBarcellos, Heloisa Helena de AlcantaraPiato, Angelo Luis StapassoliBarcellos, Leonardo Jose Gil2019-07-31T02:30:29Z20182045-2322http://hdl.handle.net/10183/197550001093276Here we show that the novel object recognition test can discriminate between high (HRN, neophobic) and low (LRN, neophilic) novelty responders in zebrafish populations. Especially when we observe the latency to the first entry in the novel object zone, zebrafish did not maintain these behavioral phenotypes in sequential tests and only the HRN group returned to their initial responsive behavior when exposed to fluoxetine. Our results have important implications for behavioral data analysis since such behavioral differences can potentially increase individual response variability and interfere with the outcomes obtained from various behavioral tasks. Our data reinforce the validity of personality determination in zebrafish since we show clear differences in behavior in response to fluoxetine.application/pdfengScientific reports. London. Vol. 8 (2018), 13908, 9 p.Peixe-zebraComportamentoFluoxetinaFluoxetine (FLU)Objective zoneNovel Object Recognition (NOR)Zebrafish populationsBehavioral phenotypesDivergent action of fluoxetine in zebrafish according to responsivity to noveltyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001093276.pdf.txt001093276.pdf.txtExtracted Texttext/plain37633http://www.lume.ufrgs.br/bitstream/10183/197550/2/001093276.pdf.txt08a0ccdaf44fbb6ffbb264a0af6903ecMD52ORIGINAL001093276.pdfTexto completo (inglês)application/pdf1852546http://www.lume.ufrgs.br/bitstream/10183/197550/1/001093276.pdf205e9f2a2ec6d51b940915cd22040067MD5110183/1975502024-05-01 06:51:26.155027oai:www.lume.ufrgs.br:10183/197550Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-05-01T09:51:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Divergent action of fluoxetine in zebrafish according to responsivity to novelty |
title |
Divergent action of fluoxetine in zebrafish according to responsivity to novelty |
spellingShingle |
Divergent action of fluoxetine in zebrafish according to responsivity to novelty Fior, Débora Peixe-zebra Comportamento Fluoxetina Fluoxetine (FLU) Objective zone Novel Object Recognition (NOR) Zebrafish populations Behavioral phenotypes |
title_short |
Divergent action of fluoxetine in zebrafish according to responsivity to novelty |
title_full |
Divergent action of fluoxetine in zebrafish according to responsivity to novelty |
title_fullStr |
Divergent action of fluoxetine in zebrafish according to responsivity to novelty |
title_full_unstemmed |
Divergent action of fluoxetine in zebrafish according to responsivity to novelty |
title_sort |
Divergent action of fluoxetine in zebrafish according to responsivity to novelty |
author |
Fior, Débora |
author_facet |
Fior, Débora Dametto, Fernanda da Silveira Fagundes, Michele Rosa, João Gabriel Santos Abreu, Murilo Sander de Koakoski, Gessi Idalencio, Renan Barcellos, Heloisa Helena de Alcantara Piato, Angelo Luis Stapassoli Barcellos, Leonardo Jose Gil |
author_role |
author |
author2 |
Dametto, Fernanda da Silveira Fagundes, Michele Rosa, João Gabriel Santos Abreu, Murilo Sander de Koakoski, Gessi Idalencio, Renan Barcellos, Heloisa Helena de Alcantara Piato, Angelo Luis Stapassoli Barcellos, Leonardo Jose Gil |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fior, Débora Dametto, Fernanda da Silveira Fagundes, Michele Rosa, João Gabriel Santos Abreu, Murilo Sander de Koakoski, Gessi Idalencio, Renan Barcellos, Heloisa Helena de Alcantara Piato, Angelo Luis Stapassoli Barcellos, Leonardo Jose Gil |
dc.subject.por.fl_str_mv |
Peixe-zebra Comportamento Fluoxetina |
topic |
Peixe-zebra Comportamento Fluoxetina Fluoxetine (FLU) Objective zone Novel Object Recognition (NOR) Zebrafish populations Behavioral phenotypes |
dc.subject.eng.fl_str_mv |
Fluoxetine (FLU) Objective zone Novel Object Recognition (NOR) Zebrafish populations Behavioral phenotypes |
description |
Here we show that the novel object recognition test can discriminate between high (HRN, neophobic) and low (LRN, neophilic) novelty responders in zebrafish populations. Especially when we observe the latency to the first entry in the novel object zone, zebrafish did not maintain these behavioral phenotypes in sequential tests and only the HRN group returned to their initial responsive behavior when exposed to fluoxetine. Our results have important implications for behavioral data analysis since such behavioral differences can potentially increase individual response variability and interfere with the outcomes obtained from various behavioral tasks. Our data reinforce the validity of personality determination in zebrafish since we show clear differences in behavior in response to fluoxetine. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-07-31T02:30:29Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/197550 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001093276 |
identifier_str_mv |
2045-2322 001093276 |
url |
http://hdl.handle.net/10183/197550 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Scientific reports. London. Vol. 8 (2018), 13908, 9 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/197550/2/001093276.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/197550/1/001093276.pdf |
bitstream.checksum.fl_str_mv |
08a0ccdaf44fbb6ffbb264a0af6903ec 205e9f2a2ec6d51b940915cd22040067 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224972005277696 |