Why is congenital Zika syndrome asymmetrically distributed among human populations?

Detalhes bibliográficos
Autor(a) principal: Barbeito Andrés, Jimena
Data de Publicação: 2018
Outros Autores: Faccini, Lavinia Schuler, Garcez, Patricia Pestana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/263510
Resumo: Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus’ genome as well as examining the diverse genetic and environmental cofactors of the human hosts.
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spelling Barbeito Andrés, JimenaFaccini, Lavinia SchulerGarcez, Patricia Pestana2023-08-15T03:26:30Z20181544-9173http://hdl.handle.net/10183/263510001105814Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus’ genome as well as examining the diverse genetic and environmental cofactors of the human hosts.application/pdfengPLoS Biology. San Francisco. Vol. 16, n. 8 (2018), e2006592, 11 p.Infecção por Zika virusWhy is congenital Zika syndrome asymmetrically distributed among human populations?Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001105814.pdf.txt001105814.pdf.txtExtracted Texttext/plain40482http://www.lume.ufrgs.br/bitstream/10183/263510/2/001105814.pdf.txte71a6d8471022cd30eb41204f1d6f725MD52ORIGINAL001105814.pdfTexto completo (inglês)application/pdf20024387http://www.lume.ufrgs.br/bitstream/10183/263510/1/001105814.pdfbb5f48e931eb25acdd14286730aa5632MD5110183/2635102023-08-16 03:30:46.933915oai:www.lume.ufrgs.br:10183/263510Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2023-08-16T06:30:46Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Why is congenital Zika syndrome asymmetrically distributed among human populations?
title Why is congenital Zika syndrome asymmetrically distributed among human populations?
spellingShingle Why is congenital Zika syndrome asymmetrically distributed among human populations?
Barbeito Andrés, Jimena
Infecção por Zika virus
title_short Why is congenital Zika syndrome asymmetrically distributed among human populations?
title_full Why is congenital Zika syndrome asymmetrically distributed among human populations?
title_fullStr Why is congenital Zika syndrome asymmetrically distributed among human populations?
title_full_unstemmed Why is congenital Zika syndrome asymmetrically distributed among human populations?
title_sort Why is congenital Zika syndrome asymmetrically distributed among human populations?
author Barbeito Andrés, Jimena
author_facet Barbeito Andrés, Jimena
Faccini, Lavinia Schuler
Garcez, Patricia Pestana
author_role author
author2 Faccini, Lavinia Schuler
Garcez, Patricia Pestana
author2_role author
author
dc.contributor.author.fl_str_mv Barbeito Andrés, Jimena
Faccini, Lavinia Schuler
Garcez, Patricia Pestana
dc.subject.por.fl_str_mv Infecção por Zika virus
topic Infecção por Zika virus
description Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus’ genome as well as examining the diverse genetic and environmental cofactors of the human hosts.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2023-08-15T03:26:30Z
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dc.relation.ispartof.pt_BR.fl_str_mv PLoS Biology. San Francisco. Vol. 16, n. 8 (2018), e2006592, 11 p.
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