Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/240304 |
Resumo: | We aimed to study the mechanism behind worse coronavirus disease-19 (COVID-19) outcomes in men and whether the differences between sexes regarding mortality as well as disease severity are influenced by sex hormones. To do so, we used age as a covariate in the meta-regression and subgroup analyses. This was a systematic search and meta-analysis of observational cohorts reporting COVID-19 outcomes. The PubMed (Medline) and Cochrane Library databases were searched. The primary outcome was COVID-19-associated mortality and the secondary outcome was COVID-19 severity. The study was registered at PROSPERO: 42020182924. For mortality, men had a relative risk of 1.36 (95%CI: 1.17 to 1.59; I² 63%, P for heterogeneity <0.01) compared to women. Age was not a significant covariate in meta-analysis heterogeneity (P=0.393) or subgroup analysis. For disease severity, being male was associated with a relative risk of 1.29 (95%CI: 1.19 to 1.40; I² 48%, P for heterogeneity <0.01) compared to the relative risk of women. Again, age did not influence the outcomes of the metaregression (P=0.914) or subgroup analysis. Men had a higher risk of COVID-19 mortality and severity regardless of age, decreasing the odds of hormonal influences in the described outcomes. |
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Fabião, J.Sassi, B.Pedrollo, Elis ForcelliniGerchman, FernandoKramer, Caroline KaercherLeitão, Cristiane BauermannPinto, Lana Catani Ferreira2022-06-15T04:43:15Z20220100-879Xhttp://hdl.handle.net/10183/240304001141511We aimed to study the mechanism behind worse coronavirus disease-19 (COVID-19) outcomes in men and whether the differences between sexes regarding mortality as well as disease severity are influenced by sex hormones. To do so, we used age as a covariate in the meta-regression and subgroup analyses. This was a systematic search and meta-analysis of observational cohorts reporting COVID-19 outcomes. The PubMed (Medline) and Cochrane Library databases were searched. The primary outcome was COVID-19-associated mortality and the secondary outcome was COVID-19 severity. The study was registered at PROSPERO: 42020182924. For mortality, men had a relative risk of 1.36 (95%CI: 1.17 to 1.59; I² 63%, P for heterogeneity <0.01) compared to women. Age was not a significant covariate in meta-analysis heterogeneity (P=0.393) or subgroup analysis. For disease severity, being male was associated with a relative risk of 1.29 (95%CI: 1.19 to 1.40; I² 48%, P for heterogeneity <0.01) compared to the relative risk of women. Again, age did not influence the outcomes of the metaregression (P=0.914) or subgroup analysis. Men had a higher risk of COVID-19 mortality and severity regardless of age, decreasing the odds of hormonal influences in the described outcomes.application/pdfengBrazilian journal of medical and biological research. Vol. 55 (2022), e11711, 8 p.COVID-19Hormônios esteróides gonadaisMetanáliseSexual hormoneMeta-analysisWhy do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for ageinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001141511.pdf.txt001141511.pdf.txtExtracted Texttext/plain34182http://www.lume.ufrgs.br/bitstream/10183/240304/2/001141511.pdf.txtf41f337ecce98676ca93f4f9c19207b6MD52ORIGINAL001141511.pdfTexto completo (inglês)application/pdf761404http://www.lume.ufrgs.br/bitstream/10183/240304/1/001141511.pdffcb020e01236d738077d38d920ed2741MD5110183/2403042022-06-16 04:42:53.733311oai:www.lume.ufrgs.br:10183/240304Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-06-16T07:42:53Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age |
title |
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age |
spellingShingle |
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age Fabião, J. COVID-19 Hormônios esteróides gonadais Metanálise Sexual hormone Meta-analysis |
title_short |
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age |
title_full |
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age |
title_fullStr |
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age |
title_full_unstemmed |
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age |
title_sort |
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age |
author |
Fabião, J. |
author_facet |
Fabião, J. Sassi, B. Pedrollo, Elis Forcellini Gerchman, Fernando Kramer, Caroline Kaercher Leitão, Cristiane Bauermann Pinto, Lana Catani Ferreira |
author_role |
author |
author2 |
Sassi, B. Pedrollo, Elis Forcellini Gerchman, Fernando Kramer, Caroline Kaercher Leitão, Cristiane Bauermann Pinto, Lana Catani Ferreira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Fabião, J. Sassi, B. Pedrollo, Elis Forcellini Gerchman, Fernando Kramer, Caroline Kaercher Leitão, Cristiane Bauermann Pinto, Lana Catani Ferreira |
dc.subject.por.fl_str_mv |
COVID-19 Hormônios esteróides gonadais Metanálise |
topic |
COVID-19 Hormônios esteróides gonadais Metanálise Sexual hormone Meta-analysis |
dc.subject.eng.fl_str_mv |
Sexual hormone Meta-analysis |
description |
We aimed to study the mechanism behind worse coronavirus disease-19 (COVID-19) outcomes in men and whether the differences between sexes regarding mortality as well as disease severity are influenced by sex hormones. To do so, we used age as a covariate in the meta-regression and subgroup analyses. This was a systematic search and meta-analysis of observational cohorts reporting COVID-19 outcomes. The PubMed (Medline) and Cochrane Library databases were searched. The primary outcome was COVID-19-associated mortality and the secondary outcome was COVID-19 severity. The study was registered at PROSPERO: 42020182924. For mortality, men had a relative risk of 1.36 (95%CI: 1.17 to 1.59; I² 63%, P for heterogeneity <0.01) compared to women. Age was not a significant covariate in meta-analysis heterogeneity (P=0.393) or subgroup analysis. For disease severity, being male was associated with a relative risk of 1.29 (95%CI: 1.19 to 1.40; I² 48%, P for heterogeneity <0.01) compared to the relative risk of women. Again, age did not influence the outcomes of the metaregression (P=0.914) or subgroup analysis. Men had a higher risk of COVID-19 mortality and severity regardless of age, decreasing the odds of hormonal influences in the described outcomes. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-06-15T04:43:15Z |
dc.date.issued.fl_str_mv |
2022 |
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http://hdl.handle.net/10183/240304 |
dc.language.iso.fl_str_mv |
eng |
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Brazilian journal of medical and biological research. Vol. 55 (2022), e11711, 8 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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