Correlation between the skin permeation profile of the synthetic sesquiterpene compounds, beta-caryophyllene and caryophyllene oxide, and the antiedematogenic activity by topical application of nanoemulgels

• Autor(a) principal: Weimer, Patrícia
• Data de Publicação: 2022
• Outros Autores: Kreutz, Tainá, Limberger, Renata Pereira, Rossi, Rochele Cassanta, Lima, Adley Antonini Neves de, Veiga Junior, Valdir Florencio da, Araújo, Bibiana Verlindo de, Koester, Leticia Scherer
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/249627
• topic: Sesquiterpenos; Anti-inflamatórios; Absorção cutânea; Copaiba; Copaifera multijuga; Beta-caryophyllene; Caryophyllene oxide; Nanoemulgel; Anti-inflammatory; HET-CAM assay

Sesquiterpene compounds are applied as permeation promoters in topical formulations. However, studies exploring their impact on nanostructured systems, changes in permeation profile, and consequently, its biological activity are restricted. This study aimed to investigate the correlation between the skin permeation of the major sesquiterpenes, beta-caryophyllene, and caryophyllene oxide from the oleoresin of Copaifera multijuga, after delivery into topical nanoemulgels, and the in vivo antiedematogenic activity. First, ten nanoemulgels were prepared and characterized, and their in vitro permeation profile and in vivo anti-inflammatory activity were evaluated. In equivalent concentrations, -caryophyllene permeation was greater from oleoresin nanoemulgels, resulting in greater in vivo antiedematogenic activity. However, an inverse relationship was observed for caryophyllene oxide, which showed its favored permeation and better in vivo anti-inflammatory effect carried as an isolated compound in the nanoemulgels. These results suggest that the presence of similar compounds may interfere with the permeation profile when comparing the profiles of the compounds alone or when presented in oleoresin. Furthermore, the correlation results between the permeation profile and in vivo antiedematogenic activity corroborate the establishment of betacaryophyllene as an essential compound for this pharmacological activity of C. multijuga oleoresin.