Evolutionary history of chordate PAX genes : dynamics of change in a complex gene family
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/115363 |
Resumo: | Paired box (PAX) genes are transcription factors that play important roles in embryonic development. Although the PAX gene family occurs in animals only, it is widely distributed. Among the vertebrates, its 9 genes appear to be the product of complete duplication of an original set of 4 genes, followed by an additional partial duplication. Although some studies of PAX genes have been conducted, no comprehensive survey of these genes across the entire taxonomic unit has yet been attempted. In this study, we conducted a detailed comparison of PAX sequences from 188 chordates, which revealed restricted variation. The absence of PAX4 and PAX8 among some species of reptiles and birds was notable; however, all 9 genes were present in all 74 mammalian genomes investigated. A search for signatures of selection indicated that all genes are subject to purifying selection, with a possible constraint relaxation in PAX4, PAX7, and PAX8. This result indicates asymmetric evolution of PAX family genes, which can be associated with the emergence of adaptive novelties in the chordate evolutionary trajectory. |
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Paixão Côrtes, Vanessa RodriguesSalzano, Francisco MauroBortolini, Maria Cátira2015-04-15T01:58:24Z20131932-6203http://hdl.handle.net/10183/115363000940833Paired box (PAX) genes are transcription factors that play important roles in embryonic development. Although the PAX gene family occurs in animals only, it is widely distributed. Among the vertebrates, its 9 genes appear to be the product of complete duplication of an original set of 4 genes, followed by an additional partial duplication. Although some studies of PAX genes have been conducted, no comprehensive survey of these genes across the entire taxonomic unit has yet been attempted. In this study, we conducted a detailed comparison of PAX sequences from 188 chordates, which revealed restricted variation. The absence of PAX4 and PAX8 among some species of reptiles and birds was notable; however, all 9 genes were present in all 74 mammalian genomes investigated. A search for signatures of selection indicated that all genes are subject to purifying selection, with a possible constraint relaxation in PAX4, PAX7, and PAX8. This result indicates asymmetric evolution of PAX family genes, which can be associated with the emergence of adaptive novelties in the chordate evolutionary trajectory.application/pdfengPlos One. San Francisco. Vol. 8, no. 9 (Sept. 2013), e73560, 8 p.ChordataGenesEvolutionary history of chordate PAX genes : dynamics of change in a complex gene familyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000940833.pdf000940833.pdfTexto completo (inglês)application/pdf844475http://www.lume.ufrgs.br/bitstream/10183/115363/1/000940833.pdf51536f9551f10fc6c497288f74999e38MD51TEXT000940833.pdf.txt000940833.pdf.txtExtracted Texttext/plain42393http://www.lume.ufrgs.br/bitstream/10183/115363/2/000940833.pdf.txtb17194224ecf10eaa791ab30c29413efMD52THUMBNAIL000940833.pdf.jpg000940833.pdf.jpgGenerated Thumbnailimage/jpeg2135http://www.lume.ufrgs.br/bitstream/10183/115363/3/000940833.pdf.jpge4a5b127b34827f3041794a6df28c742MD5310183/1153632023-09-23 03:34:33.592571oai:www.lume.ufrgs.br:10183/115363Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-23T06:34:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Evolutionary history of chordate PAX genes : dynamics of change in a complex gene family |
title |
Evolutionary history of chordate PAX genes : dynamics of change in a complex gene family |
spellingShingle |
Evolutionary history of chordate PAX genes : dynamics of change in a complex gene family Paixão Côrtes, Vanessa Rodrigues Chordata Genes |
title_short |
Evolutionary history of chordate PAX genes : dynamics of change in a complex gene family |
title_full |
Evolutionary history of chordate PAX genes : dynamics of change in a complex gene family |
title_fullStr |
Evolutionary history of chordate PAX genes : dynamics of change in a complex gene family |
title_full_unstemmed |
Evolutionary history of chordate PAX genes : dynamics of change in a complex gene family |
title_sort |
Evolutionary history of chordate PAX genes : dynamics of change in a complex gene family |
author |
Paixão Côrtes, Vanessa Rodrigues |
author_facet |
Paixão Côrtes, Vanessa Rodrigues Salzano, Francisco Mauro Bortolini, Maria Cátira |
author_role |
author |
author2 |
Salzano, Francisco Mauro Bortolini, Maria Cátira |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Paixão Côrtes, Vanessa Rodrigues Salzano, Francisco Mauro Bortolini, Maria Cátira |
dc.subject.por.fl_str_mv |
Chordata Genes |
topic |
Chordata Genes |
description |
Paired box (PAX) genes are transcription factors that play important roles in embryonic development. Although the PAX gene family occurs in animals only, it is widely distributed. Among the vertebrates, its 9 genes appear to be the product of complete duplication of an original set of 4 genes, followed by an additional partial duplication. Although some studies of PAX genes have been conducted, no comprehensive survey of these genes across the entire taxonomic unit has yet been attempted. In this study, we conducted a detailed comparison of PAX sequences from 188 chordates, which revealed restricted variation. The absence of PAX4 and PAX8 among some species of reptiles and birds was notable; however, all 9 genes were present in all 74 mammalian genomes investigated. A search for signatures of selection indicated that all genes are subject to purifying selection, with a possible constraint relaxation in PAX4, PAX7, and PAX8. This result indicates asymmetric evolution of PAX family genes, which can be associated with the emergence of adaptive novelties in the chordate evolutionary trajectory. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2015-04-15T01:58:24Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/115363 |
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1932-6203 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000940833 |
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1932-6203 000940833 |
url |
http://hdl.handle.net/10183/115363 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Plos One. San Francisco. Vol. 8, no. 9 (Sept. 2013), e73560, 8 p. |
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openAccess |
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