Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia

Detalhes bibliográficos
Autor(a) principal: Polita, Sandra Raquel Lermen
Data de Publicação: 2021
Outros Autores: Massuda, Raffael, Panizzutti, Bruna Schilling, Gama, Clarissa Severino, Duarte, Juliana Ávila
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/233457
Resumo: Introduction: It is well established that cortical volume are decreased in patients with schizophrenia. One possible explanation is that the increased pro-inflammatory status in schizophrenia is related to volumetric decrease of gray matter. The aim of this study was to correlate interleukin 6 (IL-6) with cortical volume in patients with schizophrenia and controls. Methods: We selected 36 patients with schizophrenia and 35 controls. Interleukin 6 (IL-6) was correlated with cortical volume in patients with schizophrenia and controls. Results: IL-6 was negatively correlated with cortical volume (p = 0.027; rho = −0.370) in patients, but not in controls (p = 0.235). Discussion: Our results are in line with previous studies suggesting that chronic inflammatory activation in patients with schizophrenia could be one plausible mechanism that could contribute for the cortical volumetric decrease often seen in this population. However, this cross-sectional study with a small number of patients does not allow us to establish causal relations.
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spelling Polita, Sandra Raquel LermenMassuda, RaffaelPanizzutti, Bruna SchillingGama, Clarissa SeverinoDuarte, Juliana Ávila2021-12-29T04:27:22Z20212357-9730http://hdl.handle.net/10183/233457001134242Introduction: It is well established that cortical volume are decreased in patients with schizophrenia. One possible explanation is that the increased pro-inflammatory status in schizophrenia is related to volumetric decrease of gray matter. The aim of this study was to correlate interleukin 6 (IL-6) with cortical volume in patients with schizophrenia and controls. Methods: We selected 36 patients with schizophrenia and 35 controls. Interleukin 6 (IL-6) was correlated with cortical volume in patients with schizophrenia and controls. Results: IL-6 was negatively correlated with cortical volume (p = 0.027; rho = −0.370) in patients, but not in controls (p = 0.235). Discussion: Our results are in line with previous studies suggesting that chronic inflammatory activation in patients with schizophrenia could be one plausible mechanism that could contribute for the cortical volumetric decrease often seen in this population. However, this cross-sectional study with a small number of patients does not allow us to establish causal relations.application/pdfengClinical and biomedical research. Porto Alegre. Vol. 41, no. 3 (2021), p. 220-223EsquizofreniaInflamaçãoImagem por ressonância magnéticaSchizophreniaInflammationMRICortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophreniainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001134242.pdf.txt001134242.pdf.txtExtracted Texttext/plain15217http://www.lume.ufrgs.br/bitstream/10183/233457/2/001134242.pdf.txt7bd31442132e41d30cecfb0874f99c67MD52ORIGINAL001134242.pdfTexto completo (inglês)application/pdf231439http://www.lume.ufrgs.br/bitstream/10183/233457/1/001134242.pdf9855208a7f9e525931885914511956ebMD5110183/2334572022-01-07 05:29:00.977492oai:www.lume.ufrgs.br:10183/233457Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-01-07T07:29Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
title Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
spellingShingle Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
Polita, Sandra Raquel Lermen
Esquizofrenia
Inflamação
Imagem por ressonância magnética
Schizophrenia
Inflammation
MRI
title_short Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
title_full Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
title_fullStr Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
title_full_unstemmed Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
title_sort Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
author Polita, Sandra Raquel Lermen
author_facet Polita, Sandra Raquel Lermen
Massuda, Raffael
Panizzutti, Bruna Schilling
Gama, Clarissa Severino
Duarte, Juliana Ávila
author_role author
author2 Massuda, Raffael
Panizzutti, Bruna Schilling
Gama, Clarissa Severino
Duarte, Juliana Ávila
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Polita, Sandra Raquel Lermen
Massuda, Raffael
Panizzutti, Bruna Schilling
Gama, Clarissa Severino
Duarte, Juliana Ávila
dc.subject.por.fl_str_mv Esquizofrenia
Inflamação
Imagem por ressonância magnética
topic Esquizofrenia
Inflamação
Imagem por ressonância magnética
Schizophrenia
Inflammation
MRI
dc.subject.eng.fl_str_mv Schizophrenia
Inflammation
MRI
description Introduction: It is well established that cortical volume are decreased in patients with schizophrenia. One possible explanation is that the increased pro-inflammatory status in schizophrenia is related to volumetric decrease of gray matter. The aim of this study was to correlate interleukin 6 (IL-6) with cortical volume in patients with schizophrenia and controls. Methods: We selected 36 patients with schizophrenia and 35 controls. Interleukin 6 (IL-6) was correlated with cortical volume in patients with schizophrenia and controls. Results: IL-6 was negatively correlated with cortical volume (p = 0.027; rho = −0.370) in patients, but not in controls (p = 0.235). Discussion: Our results are in line with previous studies suggesting that chronic inflammatory activation in patients with schizophrenia could be one plausible mechanism that could contribute for the cortical volumetric decrease often seen in this population. However, this cross-sectional study with a small number of patients does not allow us to establish causal relations.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-29T04:27:22Z
dc.date.issued.fl_str_mv 2021
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/233457
dc.identifier.issn.pt_BR.fl_str_mv 2357-9730
dc.identifier.nrb.pt_BR.fl_str_mv 001134242
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url http://hdl.handle.net/10183/233457
dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Clinical and biomedical research. Porto Alegre. Vol. 41, no. 3 (2021), p. 220-223
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