Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/199822 |
Resumo: | Objective: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. Methods: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. Results: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. Conclusion: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS. |
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Sparrenberger, KarenSilva, Mariana Sbaraini daCureau, Felipe VogtTeló, Gabriela HeidenBahia, Luciana RibeiroSchaan, Beatriz D'Agord2019-09-28T03:47:32Z20191758-5996http://hdl.handle.net/10183/199822001099948Objective: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. Methods: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. Results: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. Conclusion: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS.application/pdfengDiabetology & metabolic syndrome. London. vol. 11 (2019), 40, 9 f.AdolescenteSíndrome metabólicaObesidadeAdiponectinaAdiponectinMetabolic syndromeAdolescentsPediatricObesityHigher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescentsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001099948.pdf.txt001099948.pdf.txtExtracted Texttext/plain44209http://www.lume.ufrgs.br/bitstream/10183/199822/2/001099948.pdf.txtdcaaabb52eda55c06a92b5c94fcb2dd6MD52ORIGINAL001099948.pdfTexto completo (inglês)application/pdf902877http://www.lume.ufrgs.br/bitstream/10183/199822/1/001099948.pdfcb4113f747689f186df8f4016e80c674MD5110183/1998222019-09-29 03:45:38.161406oai:www.lume.ufrgs.br:10183/199822Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-09-29T06:45:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title |
Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
spellingShingle |
Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents Sparrenberger, Karen Adolescente Síndrome metabólica Obesidade Adiponectina Adiponectin Metabolic syndrome Adolescents Pediatric Obesity |
title_short |
Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title_full |
Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title_fullStr |
Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title_full_unstemmed |
Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title_sort |
Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
author |
Sparrenberger, Karen |
author_facet |
Sparrenberger, Karen Silva, Mariana Sbaraini da Cureau, Felipe Vogt Teló, Gabriela Heiden Bahia, Luciana Ribeiro Schaan, Beatriz D'Agord |
author_role |
author |
author2 |
Silva, Mariana Sbaraini da Cureau, Felipe Vogt Teló, Gabriela Heiden Bahia, Luciana Ribeiro Schaan, Beatriz D'Agord |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Sparrenberger, Karen Silva, Mariana Sbaraini da Cureau, Felipe Vogt Teló, Gabriela Heiden Bahia, Luciana Ribeiro Schaan, Beatriz D'Agord |
dc.subject.por.fl_str_mv |
Adolescente Síndrome metabólica Obesidade Adiponectina |
topic |
Adolescente Síndrome metabólica Obesidade Adiponectina Adiponectin Metabolic syndrome Adolescents Pediatric Obesity |
dc.subject.eng.fl_str_mv |
Adiponectin Metabolic syndrome Adolescents Pediatric Obesity |
description |
Objective: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. Methods: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. Results: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. Conclusion: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS. |
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2019 |
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Diabetology & metabolic syndrome. London. vol. 11 (2019), 40, 9 f. |
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