Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents

Detalhes bibliográficos
Autor(a) principal: Sparrenberger, Karen
Data de Publicação: 2019
Outros Autores: Silva, Mariana Sbaraini da, Cureau, Felipe Vogt, Teló, Gabriela Heiden, Bahia, Luciana Ribeiro, Schaan, Beatriz D'Agord
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/199822
Resumo: Objective: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. Methods: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. Results: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. Conclusion: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS.
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spelling Sparrenberger, KarenSilva, Mariana Sbaraini daCureau, Felipe VogtTeló, Gabriela HeidenBahia, Luciana RibeiroSchaan, Beatriz D'Agord2019-09-28T03:47:32Z20191758-5996http://hdl.handle.net/10183/199822001099948Objective: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. Methods: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. Results: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. Conclusion: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS.application/pdfengDiabetology & metabolic syndrome. London. vol. 11 (2019), 40, 9 f.AdolescenteSíndrome metabólicaObesidadeAdiponectinaAdiponectinMetabolic syndromeAdolescentsPediatricObesityHigher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescentsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001099948.pdf.txt001099948.pdf.txtExtracted Texttext/plain44209http://www.lume.ufrgs.br/bitstream/10183/199822/2/001099948.pdf.txtdcaaabb52eda55c06a92b5c94fcb2dd6MD52ORIGINAL001099948.pdfTexto completo (inglês)application/pdf902877http://www.lume.ufrgs.br/bitstream/10183/199822/1/001099948.pdfcb4113f747689f186df8f4016e80c674MD5110183/1998222019-09-29 03:45:38.161406oai:www.lume.ufrgs.br:10183/199822Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-09-29T06:45:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
spellingShingle Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
Sparrenberger, Karen
Adolescente
Síndrome metabólica
Obesidade
Adiponectina
Adiponectin
Metabolic syndrome
Adolescents
Pediatric
Obesity
title_short Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title_full Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title_fullStr Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title_full_unstemmed Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title_sort Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
author Sparrenberger, Karen
author_facet Sparrenberger, Karen
Silva, Mariana Sbaraini da
Cureau, Felipe Vogt
Teló, Gabriela Heiden
Bahia, Luciana Ribeiro
Schaan, Beatriz D'Agord
author_role author
author2 Silva, Mariana Sbaraini da
Cureau, Felipe Vogt
Teló, Gabriela Heiden
Bahia, Luciana Ribeiro
Schaan, Beatriz D'Agord
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sparrenberger, Karen
Silva, Mariana Sbaraini da
Cureau, Felipe Vogt
Teló, Gabriela Heiden
Bahia, Luciana Ribeiro
Schaan, Beatriz D'Agord
dc.subject.por.fl_str_mv Adolescente
Síndrome metabólica
Obesidade
Adiponectina
topic Adolescente
Síndrome metabólica
Obesidade
Adiponectina
Adiponectin
Metabolic syndrome
Adolescents
Pediatric
Obesity
dc.subject.eng.fl_str_mv Adiponectin
Metabolic syndrome
Adolescents
Pediatric
Obesity
description Objective: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. Methods: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. Results: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. Conclusion: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS.
publishDate 2019
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dc.relation.ispartof.pt_BR.fl_str_mv Diabetology & metabolic syndrome. London. vol. 11 (2019), 40, 9 f.
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eu_rights_str_mv openAccess
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